Seizure susceptibility corrupts inferior colliculus acoustic integration
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.3389/fnsys.2019.00063 http://hdl.handle.net/1843/56952 https://orcid.org/0000-0001-9769-9257 https://orcid.org/0000-0003-1821-1634 https://orcid.org/0000-0002-4519-3585 https://orcid.org/0000-0002-2566-2532 https://orcid.org/0000-0002-8221-594X https://orcid.org/0000-0003-0243-1309 |
Resumo: | Evidence suggests that the pathophysiology associated with epileptic susceptibility may disturb the functional connectivity of neural circuits and compromise the brain functions, even when seizures are absent. Although memory impairment is a common comorbidity found in patients with epilepsy, it is still unclear whether more caudal structures may play a role in cognitive deficits, particularly in those cases where there is no evidence of hippocampal sclerosis. This work used a genetically selected rat strain for seizure susceptibility (Wistar audiogenic rat, WAR) and distinct behavioral (motor and memory-related tasks) and electrophysiological (inferior colliculus, IC) approaches to access acoustic primary integrative network properties. The IC neural assemblies’ response was evaluated by auditory transient (focusing on bottom-up processing) and steady-state evoked response (ASSR, centering on feedforward and feedback forces over neural circuitry). The results show that WAR displayed no disturbance in motor performance or hippocampus-dependent memory tasks. Nonetheless, WAR animals exhibited significative impairment for auditory fear conditioning (AFC) along with no indicative of IC plastic changes between the pre-conditioning and test phases (ASSR coherence analysis). Furthermore, WAR’s IC response to transient stimuli presented shorter latency and higher amplitude compared with Wistar; and the ASSR analysis showed similar results for WAR and Wistar animals under subthreshold dose of pentylenetetrazol (pro-convulsive drug) for seizure-induction. Our work demonstrated alterations at WAR IC neural network processing, which may explain the associated disturbance on AFC memory. |
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2023-07-25T17:27:27Z2023-07-25T17:27:27Z201913111https://doi.org/10.3389/fnsys.2019.000631662-5137http://hdl.handle.net/1843/56952https://orcid.org/0000-0001-9769-9257https://orcid.org/0000-0003-1821-1634https://orcid.org/0000-0002-4519-3585https://orcid.org/0000-0002-2566-2532https://orcid.org/0000-0002-8221-594Xhttps://orcid.org/0000-0003-0243-1309Evidence suggests that the pathophysiology associated with epileptic susceptibility may disturb the functional connectivity of neural circuits and compromise the brain functions, even when seizures are absent. Although memory impairment is a common comorbidity found in patients with epilepsy, it is still unclear whether more caudal structures may play a role in cognitive deficits, particularly in those cases where there is no evidence of hippocampal sclerosis. This work used a genetically selected rat strain for seizure susceptibility (Wistar audiogenic rat, WAR) and distinct behavioral (motor and memory-related tasks) and electrophysiological (inferior colliculus, IC) approaches to access acoustic primary integrative network properties. The IC neural assemblies’ response was evaluated by auditory transient (focusing on bottom-up processing) and steady-state evoked response (ASSR, centering on feedforward and feedback forces over neural circuitry). The results show that WAR displayed no disturbance in motor performance or hippocampus-dependent memory tasks. Nonetheless, WAR animals exhibited significative impairment for auditory fear conditioning (AFC) along with no indicative of IC plastic changes between the pre-conditioning and test phases (ASSR coherence analysis). Furthermore, WAR’s IC response to transient stimuli presented shorter latency and higher amplitude compared with Wistar; and the ASSR analysis showed similar results for WAR and Wistar animals under subthreshold dose of pentylenetetrazol (pro-convulsive drug) for seizure-induction. Our work demonstrated alterations at WAR IC neural network processing, which may explain the associated disturbance on AFC memory.porUniversidade Federal de Minas GeraisUFMGBrasilENG - DEPARTAMENTO DE ENGENHARIA ELETRÔNICAICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICAFrontiers in systems neuroscienceProcesso estacionarioFisiopatologiaExcitatory-inhibitory imbalanceWistar audiogenic ratCognitive functionsSteady-state evoked responseTransient evoked responseSeizure susceptibility corrupts inferior colliculus acoustic integrationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/articles/10.3389/fnsys.2019.00063/fullHyorrana Priscila Pereira PintoEric Levi de Oliveira LucasVinícius Rezende CarvalhoFlávio Afonso Gonçalves MourãoLeonardo de Oliveira GuarnieriEduardo Mazoni Andrade Marçal MendesDaniel de Castro MedeirosMarcio Flavio Dutra Moraesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56952/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALSeizure Susceptibility Corrupts Inferior Colliculus Acoustic Integration.pdfSeizure Susceptibility Corrupts Inferior Colliculus Acoustic Integration.pdfapplication/pdf688830https://repositorio.ufmg.br/bitstream/1843/56952/2/Seizure%20Susceptibility%20Corrupts%20Inferior%20Colliculus%20Acoustic%20Integration.pdfc7892a3e942d51a638d81cbbb2d638deMD521843/569522023-07-25 14:27:27.197oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-25T17:27:27Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Seizure susceptibility corrupts inferior colliculus acoustic integration |
title |
Seizure susceptibility corrupts inferior colliculus acoustic integration |
spellingShingle |
Seizure susceptibility corrupts inferior colliculus acoustic integration Hyorrana Priscila Pereira Pinto Excitatory-inhibitory imbalance Wistar audiogenic rat Cognitive functions Steady-state evoked response Transient evoked response Processo estacionario Fisiopatologia |
title_short |
Seizure susceptibility corrupts inferior colliculus acoustic integration |
title_full |
Seizure susceptibility corrupts inferior colliculus acoustic integration |
title_fullStr |
Seizure susceptibility corrupts inferior colliculus acoustic integration |
title_full_unstemmed |
Seizure susceptibility corrupts inferior colliculus acoustic integration |
title_sort |
Seizure susceptibility corrupts inferior colliculus acoustic integration |
author |
Hyorrana Priscila Pereira Pinto |
author_facet |
Hyorrana Priscila Pereira Pinto Eric Levi de Oliveira Lucas Vinícius Rezende Carvalho Flávio Afonso Gonçalves Mourão Leonardo de Oliveira Guarnieri Eduardo Mazoni Andrade Marçal Mendes Daniel de Castro Medeiros Marcio Flavio Dutra Moraes |
author_role |
author |
author2 |
Eric Levi de Oliveira Lucas Vinícius Rezende Carvalho Flávio Afonso Gonçalves Mourão Leonardo de Oliveira Guarnieri Eduardo Mazoni Andrade Marçal Mendes Daniel de Castro Medeiros Marcio Flavio Dutra Moraes |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Hyorrana Priscila Pereira Pinto Eric Levi de Oliveira Lucas Vinícius Rezende Carvalho Flávio Afonso Gonçalves Mourão Leonardo de Oliveira Guarnieri Eduardo Mazoni Andrade Marçal Mendes Daniel de Castro Medeiros Marcio Flavio Dutra Moraes |
dc.subject.por.fl_str_mv |
Excitatory-inhibitory imbalance Wistar audiogenic rat Cognitive functions Steady-state evoked response Transient evoked response |
topic |
Excitatory-inhibitory imbalance Wistar audiogenic rat Cognitive functions Steady-state evoked response Transient evoked response Processo estacionario Fisiopatologia |
dc.subject.other.pt_BR.fl_str_mv |
Processo estacionario Fisiopatologia |
description |
Evidence suggests that the pathophysiology associated with epileptic susceptibility may disturb the functional connectivity of neural circuits and compromise the brain functions, even when seizures are absent. Although memory impairment is a common comorbidity found in patients with epilepsy, it is still unclear whether more caudal structures may play a role in cognitive deficits, particularly in those cases where there is no evidence of hippocampal sclerosis. This work used a genetically selected rat strain for seizure susceptibility (Wistar audiogenic rat, WAR) and distinct behavioral (motor and memory-related tasks) and electrophysiological (inferior colliculus, IC) approaches to access acoustic primary integrative network properties. The IC neural assemblies’ response was evaluated by auditory transient (focusing on bottom-up processing) and steady-state evoked response (ASSR, centering on feedforward and feedback forces over neural circuitry). The results show that WAR displayed no disturbance in motor performance or hippocampus-dependent memory tasks. Nonetheless, WAR animals exhibited significative impairment for auditory fear conditioning (AFC) along with no indicative of IC plastic changes between the pre-conditioning and test phases (ASSR coherence analysis). Furthermore, WAR’s IC response to transient stimuli presented shorter latency and higher amplitude compared with Wistar; and the ASSR analysis showed similar results for WAR and Wistar animals under subthreshold dose of pentylenetetrazol (pro-convulsive drug) for seizure-induction. Our work demonstrated alterations at WAR IC neural network processing, which may explain the associated disturbance on AFC memory. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2023-07-25T17:27:27Z |
dc.date.available.fl_str_mv |
2023-07-25T17:27:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56952 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3389/fnsys.2019.00063 |
dc.identifier.issn.pt_BR.fl_str_mv |
1662-5137 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0001-9769-9257 https://orcid.org/0000-0003-1821-1634 https://orcid.org/0000-0002-4519-3585 https://orcid.org/0000-0002-2566-2532 https://orcid.org/0000-0002-8221-594X https://orcid.org/0000-0003-0243-1309 |
url |
https://doi.org/10.3389/fnsys.2019.00063 http://hdl.handle.net/1843/56952 https://orcid.org/0000-0001-9769-9257 https://orcid.org/0000-0003-1821-1634 https://orcid.org/0000-0002-4519-3585 https://orcid.org/0000-0002-2566-2532 https://orcid.org/0000-0002-8221-594X https://orcid.org/0000-0003-0243-1309 |
identifier_str_mv |
1662-5137 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in systems neuroscience |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ENG - DEPARTAMENTO DE ENGENHARIA ELETRÔNICA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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