Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.3389/fmolb.2021.770471 http://hdl.handle.net/1843/60521 https://orcid.org/0000-0002-6558-4639 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2023-11-06T20:41:18Z2023-11-06T20:41:18Z2022877047110https://doi.org/10.3389/fmolb.2021.7704712296-889Xhttp://hdl.handle.net/1843/60521https://orcid.org/0000-0002-6558-4639CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorPreclinical evidence suggests the potential of Phα1β, a toxin obtained from the venom of spider Phoneutria nigriventer, as a new analgesic drug. Molecular brain imaging techniques have afforded exciting opportunities to examine brain processes in clinical pain conditions. This paper aims to study the brain regions involved in the analgesic effects of Phα1β compared with Morphine, in a model of acute pain induced by formalin in Sprague Dawley rats. We used 18F-fluorodeoxyglucose as a metabolic radiotracer to perform brain imaging of rats pretreated with Phα1β or Morphine in a model of acute inflammatory pain caused by intraplantar injection of formalin. The rats’ hind paw’s formalin stimulation resulted in a brain metabolic increase at the bilateral motor cortex, visual cortex, somatosensory cortex, thalamus, and cingulate cortex.In rats treated with Phα1β, selective inhibition of unilateral motor cortex and cingulate cortex was observed. Morphine treatment leads to small and selective inhibition at the bilateral amygdala striatum and accumbens. Our results indicate that the analgesic effect of Phα1β and Morphine possesses a differential profile of central processing in the pain state.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE SAÚDE MENTALMEDICINA - FACULDADE DE MEDICINAFrontiers in Molecular BiosciencesDorMorfinaEncéfaloP. E. TPainMorphinePhα1βBrain18F-FDGMapping of Brain Activity in the Analgesia Induced by Phα1β and Morphineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/articles/10.3389/fmolb.2021.770471/fullDanuza Montijo DinizCélio Jose Castro JuniorCarlos MalamutMarina Rios AraújoAndrea Vidal FerreiraJuliana Figueira SilvaMarta do Nascimento CordeiroMarcia Helena BorgesMarco Aurelio Romano SilvaMarcus Vinicius Gomezapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60521/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALMapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine.pdfMapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine.pdfapplication/pdf438141https://repositorio.ufmg.br/bitstream/1843/60521/2/Mapping%20of%20Brain%20Activity%20in%20the%20Analgesia%20Induced%20by%20Ph%ce%b11%ce%b2%20and%20Morphine.pdfdf5ddf8b3af9a2719d2f52b395d44bc1MD521843/605212023-11-06 17:41:18.615oai:repositorio.ufmg.br:1843/60521Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-11-06T20:41:18Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine |
| title |
Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine |
| spellingShingle |
Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine Danuza Montijo Diniz P. E. T Pain Morphine Phα1β Brain 18F-FDG Dor Morfina Encéfalo |
| title_short |
Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine |
| title_full |
Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine |
| title_fullStr |
Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine |
| title_full_unstemmed |
Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine |
| title_sort |
Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine |
| author |
Danuza Montijo Diniz |
| author_facet |
Danuza Montijo Diniz Célio Jose Castro Junior Carlos Malamut Marina Rios Araújo Andrea Vidal Ferreira Juliana Figueira Silva Marta do Nascimento Cordeiro Marcia Helena Borges Marco Aurelio Romano Silva Marcus Vinicius Gomez |
| author_role |
author |
| author2 |
Célio Jose Castro Junior Carlos Malamut Marina Rios Araújo Andrea Vidal Ferreira Juliana Figueira Silva Marta do Nascimento Cordeiro Marcia Helena Borges Marco Aurelio Romano Silva Marcus Vinicius Gomez |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Danuza Montijo Diniz Célio Jose Castro Junior Carlos Malamut Marina Rios Araújo Andrea Vidal Ferreira Juliana Figueira Silva Marta do Nascimento Cordeiro Marcia Helena Borges Marco Aurelio Romano Silva Marcus Vinicius Gomez |
| dc.subject.por.fl_str_mv |
P. E. T Pain Morphine Phα1β Brain 18F-FDG |
| topic |
P. E. T Pain Morphine Phα1β Brain 18F-FDG Dor Morfina Encéfalo |
| dc.subject.other.pt_BR.fl_str_mv |
Dor Morfina Encéfalo |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022 |
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2022 |
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2023-11-06T20:41:18Z |
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2023-11-06T20:41:18Z |
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info:eu-repo/semantics/publishedVersion |
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http://hdl.handle.net/1843/60521 |
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https://doi.org/10.3389/fmolb.2021.770471 |
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2296-889X |
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https://orcid.org/0000-0002-6558-4639 |
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https://doi.org/10.3389/fmolb.2021.770471 http://hdl.handle.net/1843/60521 https://orcid.org/0000-0002-6558-4639 |
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2296-889X |
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eng |
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eng |
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Frontiers in Molecular Biosciences |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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MED - DEPARTAMENTO DE SAÚDE MENTAL MEDICINA - FACULDADE DE MEDICINA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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