Evaluation of the biomarkers HMGB1 and IL-6 as predictors of mortality in cirrhotic patients with acute kidney injury
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1155/2020/2867241 http://hdl.handle.net/1843/51786 https://orcid.org/0000-0002-0506-9627 https://orcid.org/0000-0002-3716-0919 https://orcid.org/0000-0002-4103-7307 https://orcid.org/0000-0002-5443-7553 |
Resumo: | Background: Acute kidney injury (AKI) affects from 20% to 50% of cirrhotic patients, and the one-month mortality rate is 60%. The main cause of AKI is bacterial infection, which worsens circulatory dysfunction through the release of HMGB1 and IL-6. Objectives: To evaluate HMGB1 and IL-6 as biomarkers of morbidity/mortality. Methods: Prospective, observational study of 25 hospitalised cirrhotic patients with AKI. Clinical and laboratory data were collected at the time of diagnosis of AKI, including serum HMGB1 and IL-6. Results: The mean age was 55 years; 70% were male. Infections accounted for 13 cases. The 30-day and three-month mortality rates were 17.4% and 30.4%, respectively. HMGB1 levels were lower in survivors than in nonsurvivors at 30 days (1174.2 pg/mL versus 3338.5 pg/mL, p = 0:035), but not at three months (1540 pg/mL versus 2352 pg/mL, p = 0:243). Serum IL-6 levels were 43.3 pg/mL versus 153.3 pg/mL (p = 0:061) at 30 days and 35.8 pg/mL versus 87.9 pg/mL (p = 0:071) at three months, respectively. The area under the ROC curve for HMGB1 was 0.842 and 0.657, and that for IL-6 was 0.803 and 0.743 for discriminating nonsurvivors at 30 days and three months, respectively. In multivariate analysis, no biomarker was independently associated with mortality. Conclusion: HMGB1 levels were associated with decreased survival in cirrhotics. Larger studies are needed to confirm our results. |
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2023-04-11T00:52:22Z2023-04-11T00:52:22Z2020-09-252020https://doi.org/10.1155/2020/28672410962-9351http://hdl.handle.net/1843/51786https://orcid.org/0000-0002-0506-9627https://orcid.org/0000-0002-3716-0919https://orcid.org/0000-0002-4103-7307https://orcid.org/0000-0002-5443-7553Background: Acute kidney injury (AKI) affects from 20% to 50% of cirrhotic patients, and the one-month mortality rate is 60%. The main cause of AKI is bacterial infection, which worsens circulatory dysfunction through the release of HMGB1 and IL-6. Objectives: To evaluate HMGB1 and IL-6 as biomarkers of morbidity/mortality. Methods: Prospective, observational study of 25 hospitalised cirrhotic patients with AKI. Clinical and laboratory data were collected at the time of diagnosis of AKI, including serum HMGB1 and IL-6. Results: The mean age was 55 years; 70% were male. Infections accounted for 13 cases. The 30-day and three-month mortality rates were 17.4% and 30.4%, respectively. HMGB1 levels were lower in survivors than in nonsurvivors at 30 days (1174.2 pg/mL versus 3338.5 pg/mL, p = 0:035), but not at three months (1540 pg/mL versus 2352 pg/mL, p = 0:243). Serum IL-6 levels were 43.3 pg/mL versus 153.3 pg/mL (p = 0:061) at 30 days and 35.8 pg/mL versus 87.9 pg/mL (p = 0:071) at three months, respectively. The area under the ROC curve for HMGB1 was 0.842 and 0.657, and that for IL-6 was 0.803 and 0.743 for discriminating nonsurvivors at 30 days and three months, respectively. In multivariate analysis, no biomarker was independently associated with mortality. Conclusion: HMGB1 levels were associated with decreased survival in cirrhotics. Larger studies are needed to confirm our results.Introdução: A lesão renal aguda (LRA) afeta de 20% a 50% dos pacientes cirróticos, e a taxa de mortalidade em um mês é de 60%. A principal causa da LRA é a infecção bacteriana, que piora a disfunção circulatória por meio da liberação de HMGB1 e IL-6. Objetivos: Avaliar HMGB1 e IL-6 como biomarcadores de morbimortalidade. Métodos: Estudo observacional prospectivo de 25 pacientes cirróticos hospitalizados com LRA. Dados clínicos e laboratoriais foram coletados no momento do diagnóstico de IRA, incluindo HMGB1 e IL-6 séricos. Resultados: A média de idade foi de 55 anos; 70% eram do sexo masculino. As infecções foram responsáveis por 13 casos. As taxas de mortalidade em 30 dias e três meses foram de 17,4% e 30,4%, respectivamente. Os níveis de HMGB1 foram mais baixos em sobreviventes do que em não sobreviventes em 30 dias (1.174,2 pg/mL versus 3.338,5 pg/mL, p = 0:035), mas não em três meses (1.540 pg/mL versus 2.352 pg/mL, p = 0: 243). Os níveis séricos de IL-6 foram 43,3 pg/mL versus 153,3 pg/mL (p = 0:061) em 30 dias e 35,8 pg/mL versus 87,9 pg/mL (p = 0:071) em três meses, respectivamente. A área sob a curva ROC para HMGB1 foi de 0,842 e 0,657, e para IL-6 foi de 0,803 e 0,743 para discriminar não sobreviventes em 30 dias e três meses, respectivamente. Na análise multivariada, nenhum biomarcador foi independentemente associado à mortalidade. Conclusão: Os níveis de HMGB1 foram associados com diminuição da sobrevida em cirróticos. Estudos maiores são necessários para confirmar nossos resultados.FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisengUniversidade Federal de Minas GeraisUFMGBrasilHCL - HOSPITAL DAS CLINICASMED - DEPARTAMENTO DE CLÍNICA MÉDICAMediators of InflammationInjúria renal agudaFibroseBiomarcadoresMorbidadeMortalidadeAcute kidney injuryCirrhotic patientsBiomarkersMorbidityMortalityEvaluation of the biomarkers HMGB1 and IL-6 as predictors of mortality in cirrhotic patients with acute kidney injuryAvaliação dos biomarcadores HMGB1 e IL-6 como preditores de mortalidade em pacientes cirróticos com lesão renal agudainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.hindawi.com/journals/mi/2020/2867241/Célio Geraldo de Oliveira GomesMarcus Vinicius Melo de AndradeLudmila Resende GuedesHenrique Carvalho RochaRoberto Gardone GuimarãesFernando Antônio Castro CarvalhoEduardo Garcia Vilelaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/51786/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALEvaluation of the Biomarkers HMGB1 and IL-6 as Predictors of Mortality in Cirrhotic Patients with Acute Kidney Injury.pdfEvaluation of the Biomarkers HMGB1 and IL-6 as Predictors of Mortality in Cirrhotic Patients with Acute Kidney Injury.pdfapplication/pdf169942https://repositorio.ufmg.br/bitstream/1843/51786/2/Evaluation%20of%20the%20Biomarkers%20HMGB1%20and%20IL-6%20as%20Predictors%20of%20Mortality%20in%20Cirrhotic%20Patients%20with%20Acute%20Kidney%20Injury.pdf569a6428aa06b26e20f2644e25ea8bf5MD521843/517862023-04-10 21:52:22.363oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-04-11T00:52:22Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Evaluation of the biomarkers HMGB1 and IL-6 as predictors of mortality in cirrhotic patients with acute kidney injury |
dc.title.alternative.pt_BR.fl_str_mv |
Avaliação dos biomarcadores HMGB1 e IL-6 como preditores de mortalidade em pacientes cirróticos com lesão renal aguda |
title |
Evaluation of the biomarkers HMGB1 and IL-6 as predictors of mortality in cirrhotic patients with acute kidney injury |
spellingShingle |
Evaluation of the biomarkers HMGB1 and IL-6 as predictors of mortality in cirrhotic patients with acute kidney injury Célio Geraldo de Oliveira Gomes Acute kidney injury Cirrhotic patients Biomarkers Morbidity Mortality Injúria renal aguda Fibrose Biomarcadores Morbidade Mortalidade |
title_short |
Evaluation of the biomarkers HMGB1 and IL-6 as predictors of mortality in cirrhotic patients with acute kidney injury |
title_full |
Evaluation of the biomarkers HMGB1 and IL-6 as predictors of mortality in cirrhotic patients with acute kidney injury |
title_fullStr |
Evaluation of the biomarkers HMGB1 and IL-6 as predictors of mortality in cirrhotic patients with acute kidney injury |
title_full_unstemmed |
Evaluation of the biomarkers HMGB1 and IL-6 as predictors of mortality in cirrhotic patients with acute kidney injury |
title_sort |
Evaluation of the biomarkers HMGB1 and IL-6 as predictors of mortality in cirrhotic patients with acute kidney injury |
author |
Célio Geraldo de Oliveira Gomes |
author_facet |
Célio Geraldo de Oliveira Gomes Marcus Vinicius Melo de Andrade Ludmila Resende Guedes Henrique Carvalho Rocha Roberto Gardone Guimarães Fernando Antônio Castro Carvalho Eduardo Garcia Vilela |
author_role |
author |
author2 |
Marcus Vinicius Melo de Andrade Ludmila Resende Guedes Henrique Carvalho Rocha Roberto Gardone Guimarães Fernando Antônio Castro Carvalho Eduardo Garcia Vilela |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Célio Geraldo de Oliveira Gomes Marcus Vinicius Melo de Andrade Ludmila Resende Guedes Henrique Carvalho Rocha Roberto Gardone Guimarães Fernando Antônio Castro Carvalho Eduardo Garcia Vilela |
dc.subject.por.fl_str_mv |
Acute kidney injury Cirrhotic patients Biomarkers Morbidity Mortality |
topic |
Acute kidney injury Cirrhotic patients Biomarkers Morbidity Mortality Injúria renal aguda Fibrose Biomarcadores Morbidade Mortalidade |
dc.subject.other.pt_BR.fl_str_mv |
Injúria renal aguda Fibrose Biomarcadores Morbidade Mortalidade |
description |
Background: Acute kidney injury (AKI) affects from 20% to 50% of cirrhotic patients, and the one-month mortality rate is 60%. The main cause of AKI is bacterial infection, which worsens circulatory dysfunction through the release of HMGB1 and IL-6. Objectives: To evaluate HMGB1 and IL-6 as biomarkers of morbidity/mortality. Methods: Prospective, observational study of 25 hospitalised cirrhotic patients with AKI. Clinical and laboratory data were collected at the time of diagnosis of AKI, including serum HMGB1 and IL-6. Results: The mean age was 55 years; 70% were male. Infections accounted for 13 cases. The 30-day and three-month mortality rates were 17.4% and 30.4%, respectively. HMGB1 levels were lower in survivors than in nonsurvivors at 30 days (1174.2 pg/mL versus 3338.5 pg/mL, p = 0:035), but not at three months (1540 pg/mL versus 2352 pg/mL, p = 0:243). Serum IL-6 levels were 43.3 pg/mL versus 153.3 pg/mL (p = 0:061) at 30 days and 35.8 pg/mL versus 87.9 pg/mL (p = 0:071) at three months, respectively. The area under the ROC curve for HMGB1 was 0.842 and 0.657, and that for IL-6 was 0.803 and 0.743 for discriminating nonsurvivors at 30 days and three months, respectively. In multivariate analysis, no biomarker was independently associated with mortality. Conclusion: HMGB1 levels were associated with decreased survival in cirrhotics. Larger studies are needed to confirm our results. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-09-25 |
dc.date.accessioned.fl_str_mv |
2023-04-11T00:52:22Z |
dc.date.available.fl_str_mv |
2023-04-11T00:52:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/51786 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1155/2020/2867241 |
dc.identifier.issn.pt_BR.fl_str_mv |
0962-9351 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-0506-9627 https://orcid.org/0000-0002-3716-0919 https://orcid.org/0000-0002-4103-7307 https://orcid.org/0000-0002-5443-7553 |
url |
https://doi.org/10.1155/2020/2867241 http://hdl.handle.net/1843/51786 https://orcid.org/0000-0002-0506-9627 https://orcid.org/0000-0002-3716-0919 https://orcid.org/0000-0002-4103-7307 https://orcid.org/0000-0002-5443-7553 |
identifier_str_mv |
0962-9351 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Mediators of Inflammation |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
HCL - HOSPITAL DAS CLINICAS MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Repositório Institucional da UFMG |
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