Alzheimer’s disease: risk factors and potentially protective measures

• Autor(a) principal: Marcos Vinícius Ferreira Silva
• Data de Publicação: 2019
• Outros Autores: Cristina de Mello Gomide Loures, Luan Carlos Vieira Alves, Leonardo Cruz de Souza, Karina Braga Gomes Borges, Maria das Graças Carvalho
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.1186/s12929-019-0524-y; http://hdl.handle.net/1843/46951
• topic: Alzheimer’s disease; Genetic risk factors; Acquired risk factors; Doença de Alzheimer; Fatores de risco; Genética

Alzheimer’s disease (AD) is the most common type of dementia and typically manifests through a progressive lossof episodic memory and cognitive function, subsequently causing language and visuospatial skills deficiencies, which are often accompanied by behavioral disorders such as apathy, aggressiveness and depression. The presence of extracellular plaques of insoluble β-amyloid peptide (Aβ) and neurofibrillary tangles (NFT) containing hyperphosphorylated tau protein (P-tau) in the neuronal cytoplasm is a remarkable pathophysiological cause in patients’ brains. Approximately 70% of the risk of developing AD can be attributed to genetics. However, acquired factors such as cerebrovascular diseases, diabetes, hypertension, obesity and dyslipidemia increase the risk of AD development. The aim of the present minireview was to summarize the pathophysiological mechanism and the main risk factors for AD. As a complement, some protective factors associated with alower risk of disease incidence, such as cognitive reserve, physical activity and diet will also be addressed.