Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | http://doi.org/10.4238/GMR18172 http://hdl.handle.net/1843/42345 https://orcid.org/ 0000-0001-9836-4117 |
Resumo: | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
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2022-06-08T11:36:06Z2022-06-08T11:36:06Z2019181http://doi.org/10.4238/GMR181721676-5680http://hdl.handle.net/1843/42345https://orcid.org/ 0000-0001-9836-4117FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisWe characterized six drug-resistant nosocomial isolates of Klebsiella pneumoniae obtained in a hospital located in northern Minas Gerais State, Brazil, by determining their antibiotic sensitivity profiles, detecting the blaKPC genetic marker and examining their clonal relationships. All isolates were found to be extensively drug resistant. A PCR assay was used to confirm the identity of the isolates as K. pneumoniae and assess the blaKPC gene. All isolates tested positive for the blaKPC gene, which is related to carbapenem resistance. The genetic profiles and clonal relationships among the isolates were evaluated by ERIC-PCR. All the isolates were in a single group with two distinct subgroups. Analysis of the genetic diversity among the isolates revealed that five of the six were clones, which suggests cross-transmission in this hospital environment. Five of the patients died from infection. We describe the first detection of KPC-producing K. pneumoniae isolates from a hospital in northern Minas Gerais state.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASGenetics and Molecular ResearchBacterias gram-negativasInfecções por Bactérias Gram-NegativasCharacterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniaeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.semanticscholar.org/paper/Research-Article-Characterization-and-molecular-of-Lima-Carvalho/ec00cd9bc4ae45027c20664729630a997b7218caEmerson Ribeiro LimaL. L. S. CardosoAlessandra Rejane Ericsson de Oliveira XavierAdriana Amaral CarvalhoMauro Aparecido de Sousa XavierHadison Santos Nogueira CurzioHigor Rabelo GuedesLuciano Freitas FernandesAnna Christina de AlmeidaElytania Veiga MenezesNair Amélia Prates Barretoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/42345/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALCharacterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant Klebsiella pneumoniae.pdfCharacterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant Klebsiella pneumoniae.pdfapplication/pdf1726318https://repositorio.ufmg.br/bitstream/1843/42345/2/Characterization%20and%20molecular%20epidemiology%20of%20extensively%20prevalent%20nosocomial%20isolates%20of%20drug-resistant%20Klebsiella%20pneumoniae.pdf574a8e184a8dd9215bde8e466d952b71MD521843/423452022-06-08 08:36:06.493oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-06-08T11:36:06Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae |
| title |
Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae |
| spellingShingle |
Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae Emerson Ribeiro Lima Bacterias gram-negativas Infecções por Bactérias Gram-Negativas |
| title_short |
Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae |
| title_full |
Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae |
| title_fullStr |
Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae |
| title_full_unstemmed |
Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae |
| title_sort |
Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae |
| author |
Emerson Ribeiro Lima |
| author_facet |
Emerson Ribeiro Lima L. L. S. Cardoso Alessandra Rejane Ericsson de Oliveira Xavier Adriana Amaral Carvalho Mauro Aparecido de Sousa Xavier Hadison Santos Nogueira Curzio Higor Rabelo Guedes Luciano Freitas Fernandes Anna Christina de Almeida Elytania Veiga Menezes Nair Amélia Prates Barreto |
| author_role |
author |
| author2 |
L. L. S. Cardoso Alessandra Rejane Ericsson de Oliveira Xavier Adriana Amaral Carvalho Mauro Aparecido de Sousa Xavier Hadison Santos Nogueira Curzio Higor Rabelo Guedes Luciano Freitas Fernandes Anna Christina de Almeida Elytania Veiga Menezes Nair Amélia Prates Barreto |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Emerson Ribeiro Lima L. L. S. Cardoso Alessandra Rejane Ericsson de Oliveira Xavier Adriana Amaral Carvalho Mauro Aparecido de Sousa Xavier Hadison Santos Nogueira Curzio Higor Rabelo Guedes Luciano Freitas Fernandes Anna Christina de Almeida Elytania Veiga Menezes Nair Amélia Prates Barreto |
| dc.subject.other.pt_BR.fl_str_mv |
Bacterias gram-negativas Infecções por Bactérias Gram-Negativas |
| topic |
Bacterias gram-negativas Infecções por Bactérias Gram-Negativas |
| description |
FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
| publishDate |
2019 |
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2019 |
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2022-06-08T11:36:06Z |
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2022-06-08T11:36:06Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/42345 |
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http://doi.org/10.4238/GMR18172 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1676-5680 |
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https://orcid.org/ 0000-0001-9836-4117 |
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http://doi.org/10.4238/GMR18172 http://hdl.handle.net/1843/42345 https://orcid.org/ 0000-0001-9836-4117 |
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1676-5680 |
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eng |
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eng |
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Genetics and Molecular Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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