Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | http://hdl.handle.net/1843/55695 https://orcid.org/0000-0003-0848-3740 |
Resumo: | ß-Lactam/ß-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum- -lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and the definitive therapy cohort (251 patients). The 30-day case fatality rates and other secondary outcomes were similar in the two therapy groups of the two cohorts and also in the propensity-matched cohorts. BLBLIs might be carbapenem sparing alternatives for the treatment of BSI due to ESBLs in these patients. |
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Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropeniaESBLsBloodstream infectionNeutropeniabeta-lactam/beta-lactamase inhibitorsInibidores de beta-LactamasesSepseNeutropeniaInibidores de beta-Lactamasesß-Lactam/ß-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum- -lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and the definitive therapy cohort (251 patients). The 30-day case fatality rates and other secondary outcomes were similar in the two therapy groups of the two cohorts and also in the propensity-matched cohorts. BLBLIs might be carbapenem sparing alternatives for the treatment of BSI due to ESBLs in these patients.Universidade Federal de Minas GeraisBrasilMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARUFMG2023-07-03T19:25:53Z2023-07-03T19:25:53Z2017-05-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf10.1128/aac.00164-1700664804http://hdl.handle.net/1843/55695https://orcid.org/0000-0003-0848-3740engAntimicrobial Agents and ChemotherapyCarlotagudiolPilar Martín-dávilaAlison FreifeldLucía GómezThomas GottliebMercè GurguíFabián HerreraAdriana ManzurGeorg MaschmeyerYolanda MeijeMiguel MontejoCristina Royo-cebrecosMaddalena PeghinJesús Rodríguez-bañoIsabel Ruiz-campsTeresa c. SukiennikCristian TebeJordi CarratalàEdson AbdalaMurat AkovaRocío ÁlvarezGuillermo Maestro-de la CalleAngela CanoCarlos CerveraWanessa Trindade Clementeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2023-07-11T21:06:49Zoai:repositorio.ufmg.br:1843/55695Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2023-07-11T21:06:49Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.none.fl_str_mv |
Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia |
| title |
Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia |
| spellingShingle |
Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia Carlotagudiol ESBLs Bloodstream infection Neutropenia beta-lactam/beta-lactamase inhibitors Inibidores de beta-Lactamases Sepse Neutropenia Inibidores de beta-Lactamases |
| title_short |
Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia |
| title_full |
Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia |
| title_fullStr |
Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia |
| title_full_unstemmed |
Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia |
| title_sort |
Efficacy of B-lactam/B-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum B-lactamase-producing enterobacteriaceae in hematological patients with neutropenia |
| author |
Carlotagudiol |
| author_facet |
Carlotagudiol Pilar Martín-dávila Alison Freifeld Lucía Gómez Thomas Gottlieb Mercè Gurguí Fabián Herrera Adriana Manzur Georg Maschmeyer Yolanda Meije Miguel Montejo Cristina Royo-cebrecos Maddalena Peghin Jesús Rodríguez-baño Isabel Ruiz-camps Teresa c. Sukiennik Cristian Tebe Jordi Carratalà Edson Abdala Murat Akova Rocío Álvarez Guillermo Maestro-de la Calle Angela Cano Carlos Cervera Wanessa Trindade Clemente |
| author_role |
author |
| author2 |
Pilar Martín-dávila Alison Freifeld Lucía Gómez Thomas Gottlieb Mercè Gurguí Fabián Herrera Adriana Manzur Georg Maschmeyer Yolanda Meije Miguel Montejo Cristina Royo-cebrecos Maddalena Peghin Jesús Rodríguez-baño Isabel Ruiz-camps Teresa c. Sukiennik Cristian Tebe Jordi Carratalà Edson Abdala Murat Akova Rocío Álvarez Guillermo Maestro-de la Calle Angela Cano Carlos Cervera Wanessa Trindade Clemente |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carlotagudiol Pilar Martín-dávila Alison Freifeld Lucía Gómez Thomas Gottlieb Mercè Gurguí Fabián Herrera Adriana Manzur Georg Maschmeyer Yolanda Meije Miguel Montejo Cristina Royo-cebrecos Maddalena Peghin Jesús Rodríguez-baño Isabel Ruiz-camps Teresa c. Sukiennik Cristian Tebe Jordi Carratalà Edson Abdala Murat Akova Rocío Álvarez Guillermo Maestro-de la Calle Angela Cano Carlos Cervera Wanessa Trindade Clemente |
| dc.subject.por.fl_str_mv |
ESBLs Bloodstream infection Neutropenia beta-lactam/beta-lactamase inhibitors Inibidores de beta-Lactamases Sepse Neutropenia Inibidores de beta-Lactamases |
| topic |
ESBLs Bloodstream infection Neutropenia beta-lactam/beta-lactamase inhibitors Inibidores de beta-Lactamases Sepse Neutropenia Inibidores de beta-Lactamases |
| description |
ß-Lactam/ß-lactamase inhibitors (BLBLIs) were compared to carbapenems in two cohorts of hematological neutropenic patients with extended-spectrum- -lactamase (ESBL) bloodstream infection (BSI): the empirical therapy cohort (174 patients) and the definitive therapy cohort (251 patients). The 30-day case fatality rates and other secondary outcomes were similar in the two therapy groups of the two cohorts and also in the propensity-matched cohorts. BLBLIs might be carbapenem sparing alternatives for the treatment of BSI due to ESBLs in these patients. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-05-07 2023-07-03T19:25:53Z 2023-07-03T19:25:53Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
10.1128/aac.00164-17 00664804 http://hdl.handle.net/1843/55695 https://orcid.org/0000-0003-0848-3740 |
| identifier_str_mv |
10.1128/aac.00164-17 00664804 |
| url |
http://hdl.handle.net/1843/55695 https://orcid.org/0000-0003-0848-3740 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Antimicrobial Agents and Chemotherapy |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais Brasil MED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR UFMG |
| publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais Brasil MED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR UFMG |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
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repositorio@ufmg.br |
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1816829685942714368 |