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2023-11-09T22:24:30Z2023-11-09T22:24:30Z2016621273310.1016/j.cca.2016.05.01100098981http://hdl.handle.net/1843/60755Objective: This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile. Materials and methods: D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated. Results: Cystatin C presented a better association [OR of 9.8 (3.8–25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2–12.9), 8.4 (2.5–25.4), 9.1 (2.6–31.4) and 3.5 (1.4–8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion: Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapiesengUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE MICROBIOLOGIAMED - DEPARTAMENTO DE CLÍNICA MÉDICAArchives of Endocrinology and MetabolismDiabetes Mellitus, Type 1CreatinineCystatin CAlbuminuriaD-Dimertype 1 diabetes mellitusCystatin CCreatinineAlbuminuriaAssociation between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.20945/2359-3997000000003Caroline PereiradominguetiJéssica a. FuzattoRodrigo Bastos FóscoloJanice s. ReisLuci m. DusseMaria Das Graças CarvalhoKarina b. GomesAna Paula Fernandesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60755/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALAssociation of different pdfa.pdfAssociation of different pdfa.pdfapplication/pdf164611https://repositorio.ufmg.br/bitstream/1843/60755/2/Association%20of%20different%20pdfa.pdf6e91d913c1e0894a004b1559c6de0d72MD521843/607552023-11-09 20:46:17.71oai:repositorio.ufmg.br:1843/60755Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-11-09T23:46:17Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
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