Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus

Detalhes bibliográficos
Autor(a) principal: Caroline Pereiradomingueti
Data de Publicação: 2016
Outros Autores: Jéssica a. Fuzatto, Rodrigo Bastos Fóscolo, Janice s. Reis, Luci m. Dusse, Maria Das Graças Carvalho, Karina b. Gomes, Ana Paula Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/60755
Resumo: Objective: This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile. Materials and methods: D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated. Results: Cystatin C presented a better association [OR of 9.8 (3.8–25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2–12.9), 8.4 (2.5–25.4), 9.1 (2.6–31.4) and 3.5 (1.4–8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion: Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapies
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spelling Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitusD-Dimertype 1 diabetes mellitusCystatin CCreatinineAlbuminuriaDiabetes Mellitus, Type 1CreatinineCystatin CAlbuminuriaObjective: This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile. Materials and methods: D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated. Results: Cystatin C presented a better association [OR of 9.8 (3.8–25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2–12.9), 8.4 (2.5–25.4), 9.1 (2.6–31.4) and 3.5 (1.4–8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion: Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapiesUniversidade Federal de Minas GeraisBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE MICROBIOLOGIAMED - DEPARTAMENTO DE CLÍNICA MÉDICAUFMG2023-11-09T22:24:30Z2023-11-09T22:24:30Z2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf10.1016/j.cca.2016.05.01100098981http://hdl.handle.net/1843/60755engArchives of Endocrinology and MetabolismCaroline PereiradominguetiJéssica a. FuzattoRodrigo Bastos FóscoloJanice s. ReisLuci m. DusseMaria Das Graças CarvalhoKarina b. GomesAna Paula Fernandesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2023-11-09T23:46:17Zoai:repositorio.ufmg.br:1843/60755Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2023-11-09T23:46:17Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus
title Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus
spellingShingle Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus
Caroline Pereiradomingueti
D-Dimer
type 1 diabetes mellitus
Cystatin C
Creatinine
Albuminuria
Diabetes Mellitus, Type 1
Creatinine
Cystatin C
Albuminuria
title_short Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus
title_full Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus
title_fullStr Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus
title_full_unstemmed Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus
title_sort Association between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellitus
author Caroline Pereiradomingueti
author_facet Caroline Pereiradomingueti
Jéssica a. Fuzatto
Rodrigo Bastos Fóscolo
Janice s. Reis
Luci m. Dusse
Maria Das Graças Carvalho
Karina b. Gomes
Ana Paula Fernandes
author_role author
author2 Jéssica a. Fuzatto
Rodrigo Bastos Fóscolo
Janice s. Reis
Luci m. Dusse
Maria Das Graças Carvalho
Karina b. Gomes
Ana Paula Fernandes
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Caroline Pereiradomingueti
Jéssica a. Fuzatto
Rodrigo Bastos Fóscolo
Janice s. Reis
Luci m. Dusse
Maria Das Graças Carvalho
Karina b. Gomes
Ana Paula Fernandes
dc.subject.por.fl_str_mv D-Dimer
type 1 diabetes mellitus
Cystatin C
Creatinine
Albuminuria
Diabetes Mellitus, Type 1
Creatinine
Cystatin C
Albuminuria
topic D-Dimer
type 1 diabetes mellitus
Cystatin C
Creatinine
Albuminuria
Diabetes Mellitus, Type 1
Creatinine
Cystatin C
Albuminuria
description Objective: This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile. Materials and methods: D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated. Results: Cystatin C presented a better association [OR of 9.8 (3.8–25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2–12.9), 8.4 (2.5–25.4), 9.1 (2.6–31.4) and 3.5 (1.4–8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion: Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapies
publishDate 2016
dc.date.none.fl_str_mv 2016
2023-11-09T22:24:30Z
2023-11-09T22:24:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv 10.1016/j.cca.2016.05.011
00098981
http://hdl.handle.net/1843/60755
identifier_str_mv 10.1016/j.cca.2016.05.011
00098981
url http://hdl.handle.net/1843/60755
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Archives of Endocrinology and Metabolism
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
ICB - DEPARTAMENTO DE MICROBIOLOGIA
MED - DEPARTAMENTO DE CLÍNICA MÉDICA
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
ICB - DEPARTAMENTO DE MICROBIOLOGIA
MED - DEPARTAMENTO DE CLÍNICA MÉDICA
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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