Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | http://hdl.handle.net/1843/44256 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-08-15T13:12:23Z2022-08-15T13:12:23Z2016-05-16543465347510.1007/s12035-016-9927-x1559-1182http://hdl.handle.net/1843/44256CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisOutra AgênciaDifferent factors may contribute to the development of neurodegenerative diseases. Among them, metabolic syndrome (MS), which has reached epidemic proportions, has emerged as a potential element that may be involved in neurodegeneration. Furthermore, studies have shown the importance of the sirtuin family in neuronal survival and MS, which opens the possibility of new pharmacological targets. This study investigates the influence of sirtuin metabolic pathways by examining the functional capacities of glucose-induced obesity in an excitotoxic state induced by a quinolinic acid (QA) animal model. Mice were divided into two groups that received different diets for 8 weeks: one group received a regular diet, and the other group received a high-fat diet (HF) to induce MS. The animals were submitted to a stereotaxic surgery and subdivided into four groups: Standard (ST), Standard-QA (ST-QA), HF and HF-QA. The QA groups were given a 250 nL quinolinic acid injection in the right striatum and PBS was injected in the other groups. Obese mice presented with a weight gain of 40 % more than the ST group beyond acquiring an insulin resistance. QA induced motor impairment and neurodegeneration in both ST-QA and HF-QA, although no difference was observed between these groups. The HF-QA group showed a reduction in adiposity when compared with the groups that received PBS. Therefore, the HF-QA group demonstrated a commitment-dependent metabolic pathway. The results suggest that an obesogenic diet does not aggravate the neurodegeneration induced by QA. However, the excitotoxicity induced by QA promotes a sirtuin pathway impairment that contributes to metabolic changes.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASMolecular NeurobiologyDegeneração (Patologia)Síndrome metabólicaObesidadeNeurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://link.springer.com/article/10.1007/s12035-016-9927-xLeandro Ceotto Freitas LimaSoraya Wilke SalibaJoão Marcus de Oliveira AndradeMaria Luísa CunhaPuebla Cassini-VieiraJohn David FeltenbergerLucíola da Silva BarcelosAndré Luiz Sena GuimarãesAlfredo Mauricio Batista de PaulaAntônio Carlos Pinheiro de OliveiraSérgio Henrique Sousa Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44256/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALNeurodegeneration alters metabolic profile and sirt 1 signaling in high-fat-induced obese mice.pdfNeurodegeneration alters metabolic profile and sirt 1 signaling in high-fat-induced obese mice.pdfapplication/pdf1558126https://repositorio.ufmg.br/bitstream/1843/44256/2/Neurodegeneration%20alters%20metabolic%20profile%20and%20sirt%201%20signaling%20in%20high-fat-induced%20obese%20mice.pdfdf313f652e1bfaffe694d8be13e31c68MD521843/442562022-08-15 10:12:23.763oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-15T13:12:23Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice |
| title |
Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice |
| spellingShingle |
Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice Leandro Ceotto Freitas Lima Degeneração (Patologia) Síndrome metabólica Obesidade |
| title_short |
Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice |
| title_full |
Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice |
| title_fullStr |
Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice |
| title_full_unstemmed |
Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice |
| title_sort |
Neurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese mice |
| author |
Leandro Ceotto Freitas Lima |
| author_facet |
Leandro Ceotto Freitas Lima Soraya Wilke Saliba João Marcus de Oliveira Andrade Maria Luísa Cunha Puebla Cassini-Vieira John David Feltenberger Lucíola da Silva Barcelos André Luiz Sena Guimarães Alfredo Mauricio Batista de Paula Antônio Carlos Pinheiro de Oliveira Sérgio Henrique Sousa Santos |
| author_role |
author |
| author2 |
Soraya Wilke Saliba João Marcus de Oliveira Andrade Maria Luísa Cunha Puebla Cassini-Vieira John David Feltenberger Lucíola da Silva Barcelos André Luiz Sena Guimarães Alfredo Mauricio Batista de Paula Antônio Carlos Pinheiro de Oliveira Sérgio Henrique Sousa Santos |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Leandro Ceotto Freitas Lima Soraya Wilke Saliba João Marcus de Oliveira Andrade Maria Luísa Cunha Puebla Cassini-Vieira John David Feltenberger Lucíola da Silva Barcelos André Luiz Sena Guimarães Alfredo Mauricio Batista de Paula Antônio Carlos Pinheiro de Oliveira Sérgio Henrique Sousa Santos |
| dc.subject.other.pt_BR.fl_str_mv |
Degeneração (Patologia) Síndrome metabólica Obesidade |
| topic |
Degeneração (Patologia) Síndrome metabólica Obesidade |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2016 |
| dc.date.issued.fl_str_mv |
2016-05-16 |
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2022-08-15T13:12:23Z |
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2022-08-15T13:12:23Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/44256 |
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10.1007/s12035-016-9927-x |
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1559-1182 |
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10.1007/s12035-016-9927-x 1559-1182 |
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http://hdl.handle.net/1843/44256 |
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eng |
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eng |
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Molecular Neurobiology |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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