Subclinical thyroid dysfunction was not associated with cardiac arrhythmias in a cross-sectional analysis of the elsa-brasil study

• Autor(a) principal: Kamilla Maria Araújo Brandãorajão
• Data de Publicação: 2019
• Outros Autores: Antonio Luiz Pinho Ribeiro, Valéria Maria Azeredo Passos, Isabela Judith Martins Benseñor, Pedro Guatimosim Vidigal, Cleber Pinto Camacho, Maria de Fátima Haueisen Sander Diniz
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://hdl.handle.net/1843/63154
• topic: Thyroid Diseases; Pathologic Processes; Thyrotrophs; Arrhythmias, Cardiac; Adult; Thyroid Diseases; Pathologic Processes; Thyrotrophs; Arrhythmias, Cardiac; Adult

Objective: To investigate whether STD was associated with cardiac arrhythmias in a cohort of middle-aged and older adults.Methods: Baseline data of the Longitudinal Study of Adult Health, ELSA–Brasil (35–74 years) were collected from 2008 to 2010. After exclusion of clinical hypothyroidism and hyperthyroidism, participants were categorized as euthyroidism (TSH = 0.4–4.0 µU/mL), subclinical hypothyroidism (TSH > 4.0 µU/mL; FT4 = 0.8–1.9 ng/dL), and subclinical hyperthyroidism (TSH < 0.4 µU/mL; FT4 = 0.8–1.9 ng/dL). The prevalence rates of tachycardia (HR > 100) and bradycardia (HR < 60), atrial fibrillation/flutter, conduction disorders, extrasystoles, low QRS voltage, prolonged QT intervals, and persistent supraventricular rhythms were compared between groups after adjusting for age, sex, comorbidities, lifestyle, body mass index and medications.Results: The HR data of 13,341 participants (52% female; median age, 51 years) and the electrocardiogram readings of 11,795 were analyzed; 698 participants (5.23%) were classified as subclinical hypothyroidism, 193 (1.45%) as subclinical hyperthyroidism, and 12,450 (93.32%) as euthyroidism. The prevalence of rhythm and conduction disorders was similar, as were HR medians, even in the subgroups with TSH < 0.01 UI/mL or > 10.0 UI/mL or in older adults. Conduction disorders were less prevalent in older adults with subclinical hypothyroidism (adjusted OR = 0.44; 95% CI 0.24 to 0.80).Conclusion: In this large, multicenter and cross-sectional study, STD was not associated with cardiac arrhythmias, but a longitudinal assessment is necessary.