Inflammatory biomarkers responses after acute whole body vibration in fibromyalgia

• Autor(a) principal: Vanessa Gonçalves César Ribeiro
• Data de Publicação: 2018
• Outros Autores: Vanessa Amaral Mendonça, Ana Lúcia Cristino de Souza, Sueli Ferreira da Fonseca, Ana Cristina Resende Camargos, Vanessa Kelly da Silva Lage, Camila Danielle Cunha Neves, Jousielle Márcia dos Santos, Leonardo Augusto da Costa Teixeira, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira Júnior, Bruno Mezêncio, José Sebastião Cunha Fernandes, Hércules Ribeiro Leite, Jacques Remi Poortmans, Ana Cristina Rodrigues Lacerda
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.1590/1414-431X20176775; http://hdl.handle.net/1843/47250; http://orcid.org/0000-0003-3809-7285; https://orcid.org/0000-0002-1696-6091; https://orcid.org/0000-0001-8170-5827; https://orcid.org/0000-0001-8020-8511; http://orcid.org/0000-0003-2719-4231; https://orcid.org/0000-0002-0381-5622; https://orcid.org/0000-0003-0158-7918; https://orcid.org/0000-0002-4147-5614; http://orcid.org/0000-0002-9621-5422; https://orcid.org/0000-0001-6293-5571; http://orcid.org/0000-0001-5223-9943; http://orcid.org/0000-0001-8977-8131; https://orcid.org/0000-0001-5366-3754
• topic: Biomarkers; Fibromyalgia; Clinical trial; Inflammation; Acute exercise; Biomarcadores; Fibromialgia; Ensaio clínico; Inflamação; Exercícios físicos

The aims of this study were 1) to characterize the intensity of the vibration stimulation in women diagnosed with fibromyalgia (FM) compared to a control group of healthy women (HW) matched by age and anthropometric parameters, and 2) to investigate the effect of a single session of whole body vibration (WBV) on inflammatory responses. Levels of adipokines, soluble tumor necrosis factor receptors (sTNFr1, sTNFr2), and brain-derived neurotrophic factor (BDNF) were determined by enzyme-linked immunosorbent assay. Oxygen consumption (VO2) was estimated by a portable gas analysis system, heart rate (HR) was measured using a HR monitor, and perceived exertion (RPE) was evaluated using the Borg scale of perceived exertion. Acutely mild WBV increased VO2 and HR similarly in both groups. There was an interaction (disease vs vibration) in RPE (P=0.0078), showing a higher RPE in FM compared to HW at rest, which further increased in FM after acute WBV, whereas it remained unchanged in HW. In addition, there was an interaction (disease vs vibration) in plasma levels of adiponectin (P=0.0001), sTNFR1 (P=0.000001), sTNFR2 (P=0.0052), leptin (P=0.0007), resistin (P=0.0166), and BDNF (P=0.0179). In conclusion, a single acute session of mild and short WBV can improve the inflammatory status in patients with FM, reaching values close to those of matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced modulation towards greater adaptation to stress response in these patients.