Association between c reactive protein and all-cause mortality in the elsa-brasil cohort

• Autor(a) principal: Chams Bmaluf
• Data de Publicação: 2020
• Outros Autores: Francesco p Cappuccio, Michelle a Miller, Sandhi Maria Barreto, Luana Giatti, Antonio Luiz Pinho Ribeiro, Pedro g Vidigal, Douglas r m Azevedo, Rosane h Griep, Sheila Maria Alvim Matos, Chen ji
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://hdl.handle.net/1843/59077
• topic: C reactive protein; Mortality; Cardiovascular Diseases; C-Reactive Protein; Mortality; Cardiovascular Diseases

Background High-sensitivity C reactive protein (hsCRP) has been proposed as a marker of incident cardiovascular disease and vascular mortality, and may also be a marker of non-vascular mortality. However, most evidence comes from either North American or European cohorts. The present proposal aims to investigate the association of hsCRP with the risk of all-cause mortality in a multiethnic Brazilian population. Methods Baseline data (2008–2010) of a cohort of 14 238 subjects participating in the Brazilian Longitudinal Study of Adult Health were used. hsCRP was assayed with immunochemistry. The association of baseline covariates with all-cause mortality was calculated by Cox regression for univariate model and adjusted for different confounders after a mean follow-up of 8.0±1.1 years. The final model was adjusted for age, sex, self-rated race/ethnicity, schooling, health behaviours and prevalent chronic disease.Results The risk of death increased steadily by quartiles of hsCRP, from 1.45 (95% CI 1.05 to 2.01) in quartile 2 to 1.95 (95% CI 1.42 to 2.69) in quartile 4, compared with quartile 1. Furthermore, the persistence of a significant graded association after the exclusion of deaths in the first year of follow-up suggests that these results are unlikely to be due to reverse causality. Finally, the HR was unaffected by the exclusion of participants who had selfreported medical history of diabetes, cancer and chronic obstructive pulmonary disease.Conclusions Our study shows that hsCRP level is associated with mortality in a highly admixed population, independent of a large set of lifestyle and clinical variables.