Mast cell degranulation in periodontal disease from HIV-infected individuals

• Autor(a) principal: Giovanna Ribeiro Souto
• Data de Publicação: 2019
• Outros Autores: Alessandro Oliveira de Jesus, Takeshi Kato Segundo, Paôlla Freitas Perdigão, Fernando de Oliveira Costa, Ricardo Alves de Mesquita
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.20396/bjos.v18i0.8656600; http://hdl.handle.net/1843/69128
• topic: mast cel; HIV Brazilian Journal of Oral Sciences; periodontal disease open acess Mast cell degranulation in periodontal disease from hiv-infected individuals infecção é assunto busca dia 30/04/2024 data publicação 10/09/2019; Mast cells Infection Inflammation Humans Mouth mucosa; Mast cells; Infections; Inflammation; Mouth mucosa; Cell count; Immune system; HIV

Aim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and stained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.