Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

• Autor(a) principal: Patrick Munk
• Data de Publicação: 2022
• Outros Autores: Fanny Berglund, Fereshteh Fani, Masoud Alebouyeh, Dearbhaile Morris, Louise O'Connor, Martin Cormican, Jacob Moran-Gilad, Antonio Battisti, Elena Lavinia Diaconu, Gianluca Corno, Andrea di Cesare, Artan Bego, Patricia Alba, Junzo Hisatsune, Liansheng Yu, Makoto Kuroda, Motoyuki Sugai, Shizuo Kayama, Zeinegul Shakenova, Ciira Kiiyukia, Eric Ng'eno, Lul Raka, Pablo Power, Kazi Jamil, Saja Adel Fakhraldeen, Tareq Alaati, Aivars B'rzi', Je'ena Avsejenko, Kristina Kokina, Madara Streikisa, Vadims Bartkevics, Ghassan M. Matar, Ziad Daoud, Catherine Rees, Asta Pereckien', Ceslova Butrimaite-Ambrozeviciene, Christian Penny, Alexandra Bastaraud, Tiavina Rasolofoarison, Jean-Marc Collard, Luc Hervé Samison, Mala Rakoto Andrianarivelo, Daniel Lawadi Banda, Arshana Amin, Dionisia Lambrinidis, Heraa Rajandas, Sivachandran Parimannan, David Spiteri, Malcolm Vella Haber, Sunita J. Santchurn, Aleksandar Vujacic, Dijana Djurovic, Brahim Bouchrif, Bouchra Karraouan, Delfino Carlos Vubil, Elizabeth Heather Jakobsen Neilson, Pushkar Pal, Heike Schmitt, Mark Van Passel, Gert-jan Jeunen, Neil Gemmell, Stephen T. Chambers, Fania Perez Mendoza, Jorge Huete-Perez, Samuel Vilchez, Akeem Olayiwola Ahmed, Karen Gibb, Ibrahim Raufu Adisa, Ismail Ayoade Odetokun, Kayode Fashae, Anne-marie Sørgaard, Astrid Louise Wester, Pia Ryrfors, Rune Holmstad, Mashkoor Mohsin, Rumina Hasan, Sadia Shakoor, Kris Coventry, Natalie Weiler Gustafson, Claudia Huber Schill, Maria Luz Zamudio Rojas, Jorge Echevarria Velasquez, Bonifacio B. Magtibay, Kris Catangcatang, Ruby Sibulo, Felipe Campos Yauce, Dariusz Wasyl, Celia Manaia, Peter Collignon, Jaqueline Rocha, Jose Martins, Pedro Álvaro, Doris di Yoong Wen, Hanseob Shin, Hor-gil Hur, Sukhwan Yoon, Golubinka Bosevska, Mihail Kochubovski, Radu Cojocaru, Susan Cassar, Olga Burduniuc, Pei-ying Hong, Meghan Rose Perry, Amy Gassama, Vladimir Radosavljevic, Moon Y. F. Tay, Rogelio Zuniga-Montanez, Stefan Wuertz, Dagmar Gava'ová, Katarína Pastuchová, Christian Brinch, Franz Allerberger, Peter Truska, Marija Trkov, Karen Keddy, Kerneels Esterhuyse, Min Joon Song, Marcos Quintela-baluja, Mariano Gomez Lopez, Marta Cerdà-Cuéllar, R. R. D. P. Perera, N. K. B. K. R. G. W. Bandara, Anowara Begum, H. I. Premasiri, Sujatha Pathirage, Kareem Charlemagne, Carolin Rutgersson, Leif Norrgren, Stefan Örn, Renate Boss, Tanja Van Der Heijden, Yu-ping Hong, Happiness Houka Kumburu, Zenat Zebin Hossain, Robinson Hammerthon Mdegela, Yaovi Mahuton Gildas Hounmanou, Kaknokrat Chonsin, Orasa Suthienkul, Visanu Thamlikitkul, Ana Maria de Roda Husman, Bawimodom Bidjada, Berthe-marie Njanpop-lafourcade, Somtinda Christelle Nikiema-pessinaba, Belkis Levent, Carlon Worrell, Cemil Kurekci, Francis Ejobi, John Bosco Kalule, Jens Thomsen, Ouidiane Obaidi, Laila Mohamed Jassim, Andrew Moore, Anne Leonard, David W. Graham, Joshua T. Bunce, Olivier Vandenberg, Lihong Zhang, William H. Gaze, Brett Lefor, Drew Capone, Emanuele Sozzi, Joe Brown, John Scott Meschke, Mark D. Sobsey, Michael Davis, Nicola Koren Beck, Ilse Pieters, Pardi Sukapanpatharam, Phuong Truong, Ronald Lilienthal, Sanghoon Kang, Thomas E. Wittum, Natalia Rigamonti, Patricia Baklayan, Chinh Dang Van, Doan Minh Nguyen Tran, Nguyen do Phuc, Dougnon Tamègnon Victorien, Geoffrey Kwenda, D. G. Joakim Larsson, Marion Koopmans, Mark Woolhouse, Frank m. Aarestrup, Angela Daniela Salazar Gutierrez, Freddy Soria, Vesna Rudi' Gruji', Frederik Duus Møller, Natas'a Mazalica, Teddie O. Rahube, Carlos Alberto Tagliati, Dalia Rodrigues, Guilherme Oliveira, Larissa Camila Ribeiro de Souza, Ivan Ivanov, Bonkoungou Isidore Juste, Traoré Oumar, Thet Sopheak, Thomas N. Petersen, Yith Vuthy, Antoinette Ngandijo, Ariane Nzouankeu, Ziem A. Abah Jacques Olivier, Christopher K. Yost, Pratik Kumar, Satinder Kaur Brar, Djim-adjim Tabo, Aiko D. Adell, Esteban Paredes-osses, Rene S. Hendriksen, Maria Cristina Martinez, Sara Cuadros-orellana, Changwen Ke, Huanying Zheng, Ii Baisheng, Lok Ting Lau, Teresa Chung, Xiaoyang Jiao, Yongjie yu, Zhao Jiayong, Anne Mette Seyfarth, Johan F. Bernal Morales, Maria Fernanda Valencia, Pilar Donado-godoy, Kalpy Julien Coulibaly, Jasna Hrenovic, Matijana Jergovi', Renáta Karpí'ková, Zozo Nyarukweba Deogratias, Lisbeth Truelstrup Hansen, Jette S. Kjeldgaard, Pernille Erland Jensen, Mohamed Abouelnaga, Bodil Elsborg, Mohamed Fathy Salem, Marliin Koolmeister, Mengistu Legesse, Tadesse Eguale, Annamari Heikinheimo, Soizick le Guyader, Julien Schaeffer, Jose Eduardo Villacis, Christina Aaby Svendsen, Bakary Sanneh, Lile Malania, Andreas Nitsche, Annika Brinkmann, Sara Schubert, Sina Hesse, Thomas U. Berendonk, Courage Kosi Setsoafia Saba, Jibril Mohammed, Patrick Kwame Feglo, Bram Van Bunnik, Regina Ama Banu, Charalampos Kotzamanidis, Efthymios Lytras, Sergio A. Lickes, Bela Kocsis, Norbert Solymosi, Thorunn R. Thorsteinsdottir, Abdulla Mohamed Hatha, Mamatha Ballal, Sohan Rodney Bangera
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.1038/s41467-022-34312-7; http://hdl.handle.net/1843/60385; https://orcid.org/0000-0001-8813-4019; https://orcid.org/0000-0002-8528-8095; https://orcid.org/0000-0002-5074-7183; https://orcid.org/0000-0002-5204-2312; https://orcid.org/0000-0003-3765-8167; https://orcid.org/0000-0002-7116-2723; https://orcid.org/0000-0003-2177-7073
• topic: Resistência microbiana a medicamentos; Vigilância epidemiológica baseada em águas residuárias; Esgotos; Genômica

Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.