Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery

Detalhes bibliográficos
Autor(a) principal: Ana Paula de Figueiredo Monteiro
Data de Publicação: 2017
Outros Autores: Larissa Durães Caminhas, José Domingos Ardisson, Roberto Magalhães Paniago, María Esperanza Cortés Segura, Rubén Dario Sinisterra Millán
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.1016/j.carbpol.2016.11.091
http://hdl.handle.net/1843/61673
https://orcid.org/0000-0002-4202-1964
https://orcid.org/0000-0001-7657-9360
https://orcid.org/0000-0002-5615-3482
https://orcid.org/0000-0002-0540-7163
https://orcid.org/0000-0002-0560-8491
https://orcid.org/0000-0001-7656-1849
Resumo: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
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spelling 2023-12-04T14:18:35Z2023-12-04T14:18:35Z2017-0516319https://doi.org/10.1016/j.carbpol.2016.11.0911879-1344http://hdl.handle.net/1843/61673https://orcid.org/0000-0002-4202-1964https://orcid.org/0000-0001-7657-9360https://orcid.org/0000-0002-5615-3482https://orcid.org/0000-0002-0540-7163https://orcid.org/0000-0002-0560-8491https://orcid.org/0000-0001-7656-1849CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)In the present work, we study the role of different components in the formation of more stable iron oxide magnetic nanoparticles (MNPs): β-cyclodextrin (BCD), 2-hydroxypropyl-β-cyclodextrin (HP) and citrate anion. MNPs formulations were characterized by FTIR, particles size measurements, zeta potential based on dynamic light scattering principle technique, X-ray powder pattern diffraction, XPS spectroscopy, transmission electron microscopy and thermogravimetric analysis. The results showed that cyclodextrins and citrate plays a key role in order to obtain a lower size of coated MNPs and proved to be an efficient strategy to obtain a more stable colloidal dispersion, avoiding the nanoparticles oxidation, enhancing the irinotecan incorporation and release. Furthermore, citrate-coated BCD-MNPs showed the same cytotoxicity of the free IRI.engUniversidade Federal de Minas GeraisUFMGBrasilFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORAICX - DEPARTAMENTO DE FÍSICAICX - DEPARTAMENTO DE QUÍMICACarbohydrate PolymersCiclodextrinasNanopartículasSistemas de distribuição de medicamentosCâncer - TratamentoPotencial zetaLuz - EspalhamentoTermogravimetriaMicroscopia eletrônica - TécnicaRaios X - DifraçãoFourier, Espectroscopia de infravermelho por transformada deCancerCitrateCyclodextrinIrinotecanMagnetic nanoparticleMagnetic nanoparticles coated with cyclodextrins and citrate for irinotecan deliveryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S0144861716313698Ana Paula de Figueiredo MonteiroLarissa Durães CaminhasJosé Domingos ArdissonRoberto Magalhães PaniagoMaría Esperanza Cortés SeguraRubén Dario Sinisterra Milláninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/61673/1/License.txtfa505098d172de0bc8864fc1287ffe22MD511843/616732023-12-04 11:18:36.105oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-12-04T14:18:36Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery
title Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery
spellingShingle Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery
Ana Paula de Figueiredo Monteiro
Cancer
Citrate
Cyclodextrin
Irinotecan
Magnetic nanoparticle
Ciclodextrinas
Nanopartículas
Sistemas de distribuição de medicamentos
Câncer - Tratamento
Potencial zeta
Luz - Espalhamento
Termogravimetria
Microscopia eletrônica - Técnica
Raios X - Difração
Fourier, Espectroscopia de infravermelho por transformada de
title_short Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery
title_full Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery
title_fullStr Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery
title_full_unstemmed Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery
title_sort Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery
author Ana Paula de Figueiredo Monteiro
author_facet Ana Paula de Figueiredo Monteiro
Larissa Durães Caminhas
José Domingos Ardisson
Roberto Magalhães Paniago
María Esperanza Cortés Segura
Rubén Dario Sinisterra Millán
author_role author
author2 Larissa Durães Caminhas
José Domingos Ardisson
Roberto Magalhães Paniago
María Esperanza Cortés Segura
Rubén Dario Sinisterra Millán
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ana Paula de Figueiredo Monteiro
Larissa Durães Caminhas
José Domingos Ardisson
Roberto Magalhães Paniago
María Esperanza Cortés Segura
Rubén Dario Sinisterra Millán
dc.subject.por.fl_str_mv Cancer
Citrate
Cyclodextrin
Irinotecan
Magnetic nanoparticle
topic Cancer
Citrate
Cyclodextrin
Irinotecan
Magnetic nanoparticle
Ciclodextrinas
Nanopartículas
Sistemas de distribuição de medicamentos
Câncer - Tratamento
Potencial zeta
Luz - Espalhamento
Termogravimetria
Microscopia eletrônica - Técnica
Raios X - Difração
Fourier, Espectroscopia de infravermelho por transformada de
dc.subject.other.pt_BR.fl_str_mv Ciclodextrinas
Nanopartículas
Sistemas de distribuição de medicamentos
Câncer - Tratamento
Potencial zeta
Luz - Espalhamento
Termogravimetria
Microscopia eletrônica - Técnica
Raios X - Difração
Fourier, Espectroscopia de infravermelho por transformada de
description CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
publishDate 2017
dc.date.issued.fl_str_mv 2017-05
dc.date.accessioned.fl_str_mv 2023-12-04T14:18:35Z
dc.date.available.fl_str_mv 2023-12-04T14:18:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/61673
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.1016/j.carbpol.2016.11.091
dc.identifier.issn.pt_BR.fl_str_mv 1879-1344
dc.identifier.orcid.pt_BR.fl_str_mv https://orcid.org/0000-0002-4202-1964
https://orcid.org/0000-0001-7657-9360
https://orcid.org/0000-0002-5615-3482
https://orcid.org/0000-0002-0540-7163
https://orcid.org/0000-0002-0560-8491
https://orcid.org/0000-0001-7656-1849
url https://doi.org/10.1016/j.carbpol.2016.11.091
http://hdl.handle.net/1843/61673
https://orcid.org/0000-0002-4202-1964
https://orcid.org/0000-0001-7657-9360
https://orcid.org/0000-0002-5615-3482
https://orcid.org/0000-0002-0540-7163
https://orcid.org/0000-0002-0560-8491
https://orcid.org/0000-0001-7656-1849
identifier_str_mv 1879-1344
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Carbohydrate Polymers
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
ICX - DEPARTAMENTO DE FÍSICA
ICX - DEPARTAMENTO DE QUÍMICA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/61673/1/License.txt
bitstream.checksum.fl_str_mv fa505098d172de0bc8864fc1287ffe22
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repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv
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