Síntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas

Detalhes bibliográficos
Autor(a) principal: Carmindo R. Borel
Data de Publicação: 2017
Outros Autores: Luiz Cláudio de Almeida Barbosa, Célia Maltha, Sergio Fernandes, Larissa Santos, Jacqueline Takahashi
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.21577/0100-4042.20170118
http://hdl.handle.net/1843/59321
https://orcid.org/0000-0002-5395-9608
Resumo: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
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spelling 2023-10-09T23:01:55Z2023-10-09T23:01:55Z201740910651073https://doi.org/10.21577/0100-4042.201701180100-4042http://hdl.handle.net/1843/59321https://orcid.org/0000-0002-5395-9608CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisIn this work a series of 2-(2- pyridyl)quinolines were prepared via a Povarov reaction between anilines, 2-pyridinocarbadehyde and ethyl vinyl ether under microwaves heating conditions. The optimized conditions herein reported allowed the preparation of several pyridylquinolines in yields in the range of 30-83%, some of them not previously accessible by this multicomponent process. The reported methodology has advantage over previous report due to its larger scope and short reaction time (2 hours). All quinolines obtained were assayed against five species of clinically important yeasts Candida sp and against Cryptococcus neoformans. Some of them possessed a broad spectrum of action including 2-(2-pyridyl)quinoline (20) and 6,8-dimethoxy-2-(pyridin-2-yl)quinolone (22) that were highly effective in inhibiting Candida species (IC50 < 1.95 µg/mL against C. tropicalis and C. krusei). Some compounds were more potent than commercial drugs Nistatin and Miconazole.porUniversidade Federal de Minas GeraisUFMGBrasilICX - DEPARTAMENTO DE QUÍMICAQuímica NovaMicroondasAtividade antifúngicasPyridylquinolineAntifungalPovarov reactionCycloadditionCandida sppSíntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicasSynthesis of 2-(2-pyridyl)quinolines promoted mby microwaves and their antigungal activitiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/qn/a/jc7LwYFcTfXr3ztJ5YjZhpv/Carmindo R. BorelLuiz Cláudio de Almeida BarbosaCélia MalthaSergio FernandesLarissa SantosJacqueline Takahashiapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/59321/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALSÍNTESE DE 2-(2-PIRIDIL)QUINOLINAS PROMOVIDA POR MICRO-ONDAS E SUAS ATIVIDADES ANTIFÚNGICAS.pdfSÍNTESE DE 2-(2-PIRIDIL)QUINOLINAS PROMOVIDA POR MICRO-ONDAS E SUAS ATIVIDADES ANTIFÚNGICAS.pdfapplication/pdf492112https://repositorio.ufmg.br/bitstream/1843/59321/2/S%c3%8dNTESE%20DE%202-%282-PIRIDIL%29QUINOLINAS%20PROMOVIDA%20POR%20MICRO-ONDAS%20E%20SUAS%20ATIVIDADES%20ANTIF%c3%9aNGICAS.pdf9fcce6f583926c706b32798c3e522f27MD521843/593212023-10-09 20:01:55.776oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-10-09T23:01:55Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Síntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas
dc.title.alternative.pt_BR.fl_str_mv Synthesis of 2-(2-pyridyl)quinolines promoted mby microwaves and their antigungal activities
title Síntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas
spellingShingle Síntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas
Carmindo R. Borel
Pyridylquinoline
Antifungal
Povarov reaction
Cycloaddition
Candida spp
Microondas
Atividade antifúngicas
title_short Síntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas
title_full Síntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas
title_fullStr Síntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas
title_full_unstemmed Síntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas
title_sort Síntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicas
author Carmindo R. Borel
author_facet Carmindo R. Borel
Luiz Cláudio de Almeida Barbosa
Célia Maltha
Sergio Fernandes
Larissa Santos
Jacqueline Takahashi
author_role author
author2 Luiz Cláudio de Almeida Barbosa
Célia Maltha
Sergio Fernandes
Larissa Santos
Jacqueline Takahashi
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Carmindo R. Borel
Luiz Cláudio de Almeida Barbosa
Célia Maltha
Sergio Fernandes
Larissa Santos
Jacqueline Takahashi
dc.subject.por.fl_str_mv Pyridylquinoline
Antifungal
Povarov reaction
Cycloaddition
Candida spp
topic Pyridylquinoline
Antifungal
Povarov reaction
Cycloaddition
Candida spp
Microondas
Atividade antifúngicas
dc.subject.other.pt_BR.fl_str_mv Microondas
Atividade antifúngicas
description CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2023-10-09T23:01:55Z
dc.date.available.fl_str_mv 2023-10-09T23:01:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/59321
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.21577/0100-4042.20170118
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
dc.identifier.orcid.pt_BR.fl_str_mv https://orcid.org/0000-0002-5395-9608
url https://doi.org/10.21577/0100-4042.20170118
http://hdl.handle.net/1843/59321
https://orcid.org/0000-0002-5395-9608
identifier_str_mv 0100-4042
dc.language.iso.fl_str_mv por
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dc.relation.ispartof.pt_BR.fl_str_mv Química Nova
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv ICX - DEPARTAMENTO DE QUÍMICA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
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