Photobiomodulation drives pericyte mobilization towards skin regeneration
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1038/s41598-020-76243-7 http://hdl.handle.net/1843/48366 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-12-22T15:44:10Z2022-12-22T15:44:10Z2020-11-061010115https://doi.org/10.1038/s41598-020-76243-72045-2322http://hdl.handle.net/1843/48366CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorPhotobiomodulation is being widely applied for improving dermal or mucosal wound healing. However, the underlying cellular and molecular processes that directly contribute to its effects remain poorly understood. Pericytes are relevant cells involved in the wound microenvironment and could be one of the main targets of photobiomodulation due to their plasticity and perivascular localization. Herein, we investigate tissue repair under the photobiomodulation stimulus using a pericyte labeled (or reporter) transgenic mice. Using a model of two contralateral back wounds, one the control and the other photoactivated daily (660 nm, 20 mW, 0.71 W/cm2, 5 J/cm2, 7 s, 0.14 J), we showed an overall influx of immune and undifferentiated cells and higher mobilization of a potent pericyte subpopulation (Type-2 pericytes) in the photoactivated wounds in comparison to the controls. Doppler analysis showed a significant increase in the blood flow in the photoactivated wounds, while marked vascular supply was observed histologically. Histochemical analysis has indicated more advanced stages of tissue repair after photoactivation. These data suggest that photobiomodulation significantly accelerates tissue repair through its vascular effects with direct recruitment of pericytes to the injury site.engUniversidade Federal de Minas GeraisUFMGBrasilFAO - FACULDADE DE ODONTOLOGIAScientific ReportsWounds and injuriesCellsBloodTissuesPhotobiomodulation drives pericyte mobilization towards skin regenerationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.nature.com/articles/s41598-020-76243-7Isabella Bittencourt do ValleRafaela Férrer de OliveiraLarissa Fassarela MarquioreSoraia MacariFlávio Almeida do AmaralHumberto Jácome-santosLucíola Silva BarcelosGustavo Batista MenezesMárcia Martins MarqueAlexander BirbrairIvana Márcia Alves DinizPedro Henrique Dias Moura PrazeresRicardo Alves MesquitaTarcília Aparecida SilvaHortência Maciel de Castro OliveiraPollyana Ribeiro CastroIuri Dornelas Prates FreitasSicília Rezende OliveiraNatália Aparecida Gomesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/48366/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALPhotobiomodulation drives pericyte mobilization towards skin regeneration.pdfPhotobiomodulation drives pericyte mobilization towards skin regeneration.pdfapplication/pdf8447614https://repositorio.ufmg.br/bitstream/1843/48366/2/Photobiomodulation%20drives%20pericyte%20mobilization%20towards%20skin%20regeneration.pdfce0582f234dcf436a3dde022b772b650MD521843/483662022-12-22 12:44:10.77oai:repositorio.ufmg.br:1843/48366TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-12-22T15:44:10Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Photobiomodulation drives pericyte mobilization towards skin regeneration |
| title |
Photobiomodulation drives pericyte mobilization towards skin regeneration |
| spellingShingle |
Photobiomodulation drives pericyte mobilization towards skin regeneration Isabella Bittencourt do Valle Wounds and injuries Cells Blood Tissues |
| title_short |
Photobiomodulation drives pericyte mobilization towards skin regeneration |
| title_full |
Photobiomodulation drives pericyte mobilization towards skin regeneration |
| title_fullStr |
Photobiomodulation drives pericyte mobilization towards skin regeneration |
| title_full_unstemmed |
Photobiomodulation drives pericyte mobilization towards skin regeneration |
| title_sort |
Photobiomodulation drives pericyte mobilization towards skin regeneration |
| author |
Isabella Bittencourt do Valle |
| author_facet |
Isabella Bittencourt do Valle Rafaela Férrer de Oliveira Larissa Fassarela Marquiore Soraia Macari Flávio Almeida do Amaral Humberto Jácome-santos Lucíola Silva Barcelos Gustavo Batista Menezes Márcia Martins Marque Alexander Birbrair Ivana Márcia Alves Diniz Pedro Henrique Dias Moura Prazeres Ricardo Alves Mesquita Tarcília Aparecida Silva Hortência Maciel de Castro Oliveira Pollyana Ribeiro Castro Iuri Dornelas Prates Freitas Sicília Rezende Oliveira Natália Aparecida Gomes |
| author_role |
author |
| author2 |
Rafaela Férrer de Oliveira Larissa Fassarela Marquiore Soraia Macari Flávio Almeida do Amaral Humberto Jácome-santos Lucíola Silva Barcelos Gustavo Batista Menezes Márcia Martins Marque Alexander Birbrair Ivana Márcia Alves Diniz Pedro Henrique Dias Moura Prazeres Ricardo Alves Mesquita Tarcília Aparecida Silva Hortência Maciel de Castro Oliveira Pollyana Ribeiro Castro Iuri Dornelas Prates Freitas Sicília Rezende Oliveira Natália Aparecida Gomes |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Isabella Bittencourt do Valle Rafaela Férrer de Oliveira Larissa Fassarela Marquiore Soraia Macari Flávio Almeida do Amaral Humberto Jácome-santos Lucíola Silva Barcelos Gustavo Batista Menezes Márcia Martins Marque Alexander Birbrair Ivana Márcia Alves Diniz Pedro Henrique Dias Moura Prazeres Ricardo Alves Mesquita Tarcília Aparecida Silva Hortência Maciel de Castro Oliveira Pollyana Ribeiro Castro Iuri Dornelas Prates Freitas Sicília Rezende Oliveira Natália Aparecida Gomes |
| dc.subject.other.pt_BR.fl_str_mv |
Wounds and injuries Cells Blood Tissues |
| topic |
Wounds and injuries Cells Blood Tissues |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2020 |
| dc.date.issued.fl_str_mv |
2020-11-06 |
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2022-12-22T15:44:10Z |
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2022-12-22T15:44:10Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/48366 |
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https://doi.org/10.1038/s41598-020-76243-7 |
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2045-2322 |
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https://doi.org/10.1038/s41598-020-76243-7 http://hdl.handle.net/1843/48366 |
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2045-2322 |
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eng |
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eng |
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Scientific Reports |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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FAO - FACULDADE DE ODONTOLOGIA |
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Universidade Federal de Minas Gerais |
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