Cystatin C and IRIS: advances in the evaluation of kidney function in critically ill dog
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.3389/fvets.2021.721845 http://hdl.handle.net/1843/52329 https://orcid.org/0000-0002-4013-0147 https://orcid.org/0000-0002-1366-7352 https://orcid.org/0000-0001-8267-4591 https://orcid.org/0000-0001-6247-2255 https://orcid.org/0000-0002-3552-458X https://orcid.org/0000-0003-0692-6587 https://orcid.org/0000-0001-8995-9805 |
Resumo: | Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mild changes in creatinine serum levels or reduction of urine output that cannot be considered biomarkers of renal injury but failure or insufficiency. Twenty-eight dogs admitted to the Intensive Care Unit under risk factors for the development of AKI were evaluated. Blood samples were collected for determination of sCr and CysC at admission and after 24, 48, and 72 h. Urine output was measured by daily monitoring, measured by collection in a closed system. The results showed the incidence of AKI was 67.9% based on the IRIS criteria and 78.6% based on cystatin C in critically ill patients’ dogs. The measurement of serum cystatin C immediately on admission to the ICU was superior in the early identification of patients with AKI when compared to the IRIS classification and serum creatinine in critically ill dogs. |
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2023-04-20T21:01:02Z2023-04-20T21:01:02Z2021-11-088https://doi.org/10.3389/fvets.2021.7218452297-1769http://hdl.handle.net/1843/52329https://orcid.org/0000-0002-4013-0147https://orcid.org/0000-0002-1366-7352https://orcid.org/0000-0001-8267-4591https://orcid.org/0000-0001-6247-2255https://orcid.org/0000-0002-3552-458Xhttps://orcid.org/0000-0003-0692-6587https://orcid.org/0000-0001-8995-9805Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mild changes in creatinine serum levels or reduction of urine output that cannot be considered biomarkers of renal injury but failure or insufficiency. Twenty-eight dogs admitted to the Intensive Care Unit under risk factors for the development of AKI were evaluated. Blood samples were collected for determination of sCr and CysC at admission and after 24, 48, and 72 h. Urine output was measured by daily monitoring, measured by collection in a closed system. The results showed the incidence of AKI was 67.9% based on the IRIS criteria and 78.6% based on cystatin C in critically ill patients’ dogs. The measurement of serum cystatin C immediately on admission to the ICU was superior in the early identification of patients with AKI when compared to the IRIS classification and serum creatinine in critically ill dogs.Cães gravemente enfermos hospitalizados estão sujeitos a algumas complicações, sendo a lesão renal aguda (LRA) uma comum. O diagnóstico precoce é crucial, e a cistatina C (CysC) é um biomarcador confiável e precoce. A Sociedade Internacional de Interesse Renal (IRIS) afirma que a gravidade da LRA pode ser avaliada por alterações leves nos níveis séricos de creatinina ou redução do débito urinário que não podem ser considerados biomarcadores de lesão renal, mas falha ou insuficiência. Foram avaliados 28 cães internados na Unidade de Terapia Intensiva com fatores de risco para o desenvolvimento de LRA. Amostras de sangue foram coletadas para determinação de sCr e CysC na admissão e após 24, 48 e 72 h. O débito urinário foi medido por monitoramento diário, medido por coleta em sistema fechado. Os resultados mostraram que a incidência de LRA foi de 67,9% com base nos critérios IRIS e 78,6% com base na cistatina C em cães de pacientes gravemente enfermos. A dosagem da cistatina C sérica imediatamente na admissão na UTI foi superior na identificação precoce de pacientes com LRA quando comparada à classificação IRIS e creatinina sérica em cães criticamente enfermos.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAVET - DEPARTAMENTO DE CLÍNICA E CIRURGIAVETER - ESCOLA DE VETERINARIAFrontiers in Veterinary ScienceMedicina veterináriaDoenças do cãoCistatina CCreatininaInjúria renal agudaDogsCystatin CCreatinineFailureInsufficiencyIllnessKidneyCystatin C and IRIS: advances in the evaluation of kidney function in critically ill dogCistatina C e IRIS: avanços na avaliação da função renal em cães criticamente enfermosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/articles/10.3389/fvets.2021.721845/fullFabíola de Oliveira Paes LemeEliana Matias de SouzaPaulo Ricardo Oliveira PaesMaderleine Geisa GomesFelipe dos Santos MunizMarco Túlio Gomes CamposRenata Barbosa PeixotoPatrícia Donado Vaz de MeloMárcio Henrique Lacerda ArndtAdriane Pimenta da Costa-Val Bicalhoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/52329/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALCystatin C and Iris Advances in the Evaluation of Kidney Function in Critically Ill Dog.pdfCystatin C and Iris Advances in the Evaluation of Kidney Function in Critically Ill Dog.pdfapplication/pdf142185https://repositorio.ufmg.br/bitstream/1843/52329/2/Cystatin%20C%20and%20Iris%20Advances%20in%20the%20Evaluation%20of%20Kidney%20Function%20in%20Critically%20Ill%20Dog.pdf353c8c7b44d13384b73b8de212a069eeMD521843/523292023-04-20 18:01:02.198oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-04-20T21:01:02Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Cystatin C and IRIS: advances in the evaluation of kidney function in critically ill dog |
dc.title.alternative.pt_BR.fl_str_mv |
Cistatina C e IRIS: avanços na avaliação da função renal em cães criticamente enfermos |
title |
Cystatin C and IRIS: advances in the evaluation of kidney function in critically ill dog |
spellingShingle |
Cystatin C and IRIS: advances in the evaluation of kidney function in critically ill dog Fabíola de Oliveira Paes Leme Dogs Cystatin C Creatinine Failure Insufficiency Illness Kidney Medicina veterinária Doenças do cão Cistatina C Creatinina Injúria renal aguda |
title_short |
Cystatin C and IRIS: advances in the evaluation of kidney function in critically ill dog |
title_full |
Cystatin C and IRIS: advances in the evaluation of kidney function in critically ill dog |
title_fullStr |
Cystatin C and IRIS: advances in the evaluation of kidney function in critically ill dog |
title_full_unstemmed |
Cystatin C and IRIS: advances in the evaluation of kidney function in critically ill dog |
title_sort |
Cystatin C and IRIS: advances in the evaluation of kidney function in critically ill dog |
author |
Fabíola de Oliveira Paes Leme |
author_facet |
Fabíola de Oliveira Paes Leme Eliana Matias de Souza Paulo Ricardo Oliveira Paes Maderleine Geisa Gomes Felipe dos Santos Muniz Marco Túlio Gomes Campos Renata Barbosa Peixoto Patrícia Donado Vaz de Melo Márcio Henrique Lacerda Arndt Adriane Pimenta da Costa-Val Bicalho |
author_role |
author |
author2 |
Eliana Matias de Souza Paulo Ricardo Oliveira Paes Maderleine Geisa Gomes Felipe dos Santos Muniz Marco Túlio Gomes Campos Renata Barbosa Peixoto Patrícia Donado Vaz de Melo Márcio Henrique Lacerda Arndt Adriane Pimenta da Costa-Val Bicalho |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fabíola de Oliveira Paes Leme Eliana Matias de Souza Paulo Ricardo Oliveira Paes Maderleine Geisa Gomes Felipe dos Santos Muniz Marco Túlio Gomes Campos Renata Barbosa Peixoto Patrícia Donado Vaz de Melo Márcio Henrique Lacerda Arndt Adriane Pimenta da Costa-Val Bicalho |
dc.subject.por.fl_str_mv |
Dogs Cystatin C Creatinine Failure Insufficiency Illness Kidney |
topic |
Dogs Cystatin C Creatinine Failure Insufficiency Illness Kidney Medicina veterinária Doenças do cão Cistatina C Creatinina Injúria renal aguda |
dc.subject.other.pt_BR.fl_str_mv |
Medicina veterinária Doenças do cão Cistatina C Creatinina Injúria renal aguda |
description |
Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mild changes in creatinine serum levels or reduction of urine output that cannot be considered biomarkers of renal injury but failure or insufficiency. Twenty-eight dogs admitted to the Intensive Care Unit under risk factors for the development of AKI were evaluated. Blood samples were collected for determination of sCr and CysC at admission and after 24, 48, and 72 h. Urine output was measured by daily monitoring, measured by collection in a closed system. The results showed the incidence of AKI was 67.9% based on the IRIS criteria and 78.6% based on cystatin C in critically ill patients’ dogs. The measurement of serum cystatin C immediately on admission to the ICU was superior in the early identification of patients with AKI when compared to the IRIS classification and serum creatinine in critically ill dogs. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-11-08 |
dc.date.accessioned.fl_str_mv |
2023-04-20T21:01:02Z |
dc.date.available.fl_str_mv |
2023-04-20T21:01:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/52329 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3389/fvets.2021.721845 |
dc.identifier.issn.pt_BR.fl_str_mv |
2297-1769 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-4013-0147 https://orcid.org/0000-0002-1366-7352 https://orcid.org/0000-0001-8267-4591 https://orcid.org/0000-0001-6247-2255 https://orcid.org/0000-0002-3552-458X https://orcid.org/0000-0003-0692-6587 https://orcid.org/0000-0001-8995-9805 |
url |
https://doi.org/10.3389/fvets.2021.721845 http://hdl.handle.net/1843/52329 https://orcid.org/0000-0002-4013-0147 https://orcid.org/0000-0002-1366-7352 https://orcid.org/0000-0001-8267-4591 https://orcid.org/0000-0001-6247-2255 https://orcid.org/0000-0002-3552-458X https://orcid.org/0000-0003-0692-6587 https://orcid.org/0000-0001-8995-9805 |
identifier_str_mv |
2297-1769 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in Veterinary Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA VET - DEPARTAMENTO DE CLÍNICA E CIRURGIA VETER - ESCOLA DE VETERINARIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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