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Fernando de Oliveira Costahttp://lattes.cnpq.br/4644477598437680Sarah Teixeira CamargosMauro Henrique Nogueira Guimarães de Abreuhttp://lattes.cnpq.br/1533176078911545Augusto Paixão Morais Mateus2023-06-07T22:02:50Z2023-06-07T22:02:50Z2022-10-27http://hdl.handle.net/1843/54689https://orcid.org/0000-0003-3543-8072As evidências científicas recentes vêm demonstrando uma possível associação entre periodontite (PE) e doenças neurodegenerativas (DN), entretanto necessitando de maiores esclarecimentos. Assim, o objetivo desse estudo caso-controle foi avaliar a aspectos clínicos e epidemiológicos da associação entre PE e DN [representadas neste estudo pela Doença de Alzheimer (DALZ) e a Doença de Parkinson (DPK)] e a influência de diversos fatores de risco envolvidos nessa associação. Um estudo caso-controle foi conduzido com 223 indivíduos, 96 indivíduos com DN (DALZ: n=43 e DPK: n=53) e 127 controles sem DN. Foram realizados exames periodontais completos, registrando índice de placa (IPL), profundidade de sondagem (PS), nível clínico de inserção (NCI) e sangramento a sondagem (SS) e coleta de variáveis biológicas e sócio-demográficas de interesse. A associação entre PE, DN e suas variáveis de risco foram testadas por meio de análise univariada e regressão logística multivariada. Foi observada alta prevalência de PE (OR; 95%IC) no grupo DN, DALZ e DPK, de respectivamente, 67.7% (5.46; 3.0-9.8; p<0.001), 60.4% (3.98; 1.9-8.3; p<0.001) e 73.5% (7.22; 3.5-15.3; p<0.001). Na análise multivariada de regressão logística os grupos casos (DN) foram associados com: PE (4.23; p<00.1), idade (2.03; p=0.021, menor número de dentes (1.98; p<0.001), uso de antidepressivos (8.45; p<0.001) e de ansiolíticos (19.98; p<0.001) Foi observado um efeito protetor para as variáveis: não uso de álcool (0.21; p<0.001) e escolaridade acima de 8 anos (0.26; p<0.001). Este estudo demonstrou uma forte associação de risco entre as doenças Alzheimer, Parkinson e periodontite.Recent scientific evidence has demonstrated a possible association between periodontitis (PE) and neurodegenerative diseases (ND). However, further clarification is needed. Therefore, the aim of this case-control study was to evaluate the clinical and epidemiological aspects of the association between PE and ND [which are represented in this study by Alzheimer's Disease (AD) and Parkinson's Disease (PKD)], along with the influence of several risk factors involved in that association. A case-control study was carried out with 223 people, 96 of which with ND (AD: n=43 and PKD: n=53) and 127 controls without ND. Complete periodontal examinations were performed in order to record plaque index (PI), probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP), and collection of biological and sociodemographic variables of interest. The association among PE, ND and their risk variables was tested using univariate analysis and multivariate logistic regression. A high prevalence of PE (OR; 95% CI) was observed in the ND, AD and PKD groups, respectively, 67.7% (5.46; 3.0-9.8; p<0.001), 60.4% (3.98; 1.9-8.3; p<0.001) and 73.5% (7.22; 3.5-15.3; p<0.001). In the multivariate logistic regression analysis the ND groups were associated with: PE (4.23; p<0.001), age (2.03; p=0.021, fewer teeth (1.98; p<0.001), use of antidepressants (8.45, p<0.001) and anxiolytics (19.98; p<0.001). A protective effect was observed for the variables: non-use of alcohol (0.21; p<0.001) and schooling of 8 years or more (0.26; p<0.001). This study demonstrated a strong risk association among Alzheimer's, Parkinson's, and periodontitis diseases.porUniversidade Federal de Minas GeraisPrograma de Pós-Graduação em OdontologiaUFMGBrasilFAO - FACULDADE DE ODONTOLOGIADoença de AlzheimerDoença de ParkinsonPeriodontiteInflamaçãoEstudos de casos e controlesNeurodegeneraçãoDoença de AlzheimerDoença de ParkinsonPeriodontiteInflamação sistêmicaEstudo caso-controleAssociação e fatores de risco entre as doença de Alzheimer, doença de Parkinson e periodontite: um estudo caso-controleAssociation and risk factors between Alzheimer’s and Parkinson’s diseases and periodontitis: a case-control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALINGLES Arquivo FINAL dissertaçao mestrado Augusto Paixão 05-04 pdf.pdfINGLES Arquivo FINAL dissertaçao mestrado Augusto Paixão 05-04 pdf.pdfapplication/pdf1288457https://repositorio.ufmg.br/bitstream/1843/54689/1/INGLES%20Arquivo%20FINAL%20%20disserta%c3%a7ao%20mestrado%20Augusto%20Paix%c3%a3o%2005-04%20pdf.pdfcf4e7b937f0481b492d51ba660513e88MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82118https://repositorio.ufmg.br/bitstream/1843/54689/2/license.txtcda590c95a0b51b4d15f60c9642ca272MD521843/546892023-06-07 19:02:50.604oai:repositorio.ufmg.br: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ório InstitucionalPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-06-07T22:02:50Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
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