The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1038/s41598-021-97429-7 http://hdl.handle.net/1843/54307 |
Resumo: | Ever since the uncultivated South American fungal pathogen Lacazia loboi was first described 90 years ago, its etiology and evolutionary traits have been at the center of endless controversies. This pathogen infects the skin of humans and as long believed, dolphin skin. However, recent DNA analyses of infected dolphins placed its DNA sequences within Paracoccidioides species. This came as a surprise and suggested the human and dolphin pathogens may be different species. In this study, population genetic analyses of DNA from four infected dolphins grouped this pathogen in a monophyletic cluster sister to P. americana and to the other Paracoccidioides species. Based on the results we have emended the taxonomy of the dolphin pathogen as Paracoccidioides cetii and P. loboi the one infecting human. Our data warn that phylogenetic analysis of available taxa without the inclusion of unusual members may provide incomplete information for the accurate classification of anomalous species. |
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2023-06-01T17:14:38Z2023-06-01T17:14:38Z202111113https://doi.org/10.1038/s41598-021-97429-72045-2322http://hdl.handle.net/1843/54307Ever since the uncultivated South American fungal pathogen Lacazia loboi was first described 90 years ago, its etiology and evolutionary traits have been at the center of endless controversies. This pathogen infects the skin of humans and as long believed, dolphin skin. However, recent DNA analyses of infected dolphins placed its DNA sequences within Paracoccidioides species. This came as a surprise and suggested the human and dolphin pathogens may be different species. In this study, population genetic analyses of DNA from four infected dolphins grouped this pathogen in a monophyletic cluster sister to P. americana and to the other Paracoccidioides species. Based on the results we have emended the taxonomy of the dolphin pathogen as Paracoccidioides cetii and P. loboi the one infecting human. Our data warn that phylogenetic analysis of available taxa without the inclusion of unusual members may provide incomplete information for the accurate classification of anomalous species.Desde que o fungo patógeno não cultivado da América do Sul, Lacazia loboi, foi descrito pela primeira vez há 90 anos, sua etiologia e características evolutivas estiveram no centro de inúmeras controvérsias. Este patógeno infecta a pele dos seres humanos e, como se acreditava, a pele dos golfinhos. No entanto, recente análises de DNA de golfinhos infectados colocaram suas sequências de DNA dentro das espécies de Paracoccidioides. Isso veio como uma surpresa e sugeriu que os patógenos humanos e dos golfinhos podem ser de espécies diferentes. Nesse estudo, análises genéticas populacionais de DNA de quatro golfinhos infectados agruparam esse patógeno em um grupo monofilético irmão de P. americana e das demais espécies de Paracoccidioides. Baseado no resultados nós corrigimos a taxonomia do patógeno do golfinho como Paracoccidioides cetii e P. loboi aquele que infecta o ser humano. Nossos dados alertam que a análise filogenética dos táxons disponíveis sem a inclusão de membros incomuns pode fornecer informações incompletas para a classificação precisa de espécies anômalas.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASScientific reportsLacaziaParacoccidioidesEcologiaGenéticaPesquisa biomédicaMicrobiologiaBiologia molecularBiological techniquesDiseasesLacaziaParacoccidioidesEcologyEvolutionGeneticsMedical researchMicrobiologyMolecular biologyThe taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analysesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.nature.com/articles/s41598-021-97429-7Raquel Virgínia Rocha VilelaMarianne HuebnerCamila Rocha VilelaGabriella Rocha VilelaBruno Batista PettersenClaudia OliveiraLeonel Mendozaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALThe taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses.pdfThe taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses.pdfapplication/pdf4114714https://repositorio.ufmg.br/bitstream/1843/54307/2/The%20taxonomy%20of%20two%20uncultivated%20fungal%20mammalian%20pathogens%20is%20revealed%20through%20phylogeny%20and%20population%20genetic%20analyses.pdfbe46e2c5085812273cb767d724e912bfMD52LICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/54307/1/License.txtfa505098d172de0bc8864fc1287ffe22MD511843/543072023-06-01 16:47:07.074oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-06-01T19:47:07Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses |
title |
The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses |
spellingShingle |
The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses Raquel Virgínia Rocha Vilela Biological techniques Diseases Lacazia Paracoccidioides Ecology Evolution Genetics Medical research Microbiology Molecular biology Lacazia Paracoccidioides Ecologia Genética Pesquisa biomédica Microbiologia Biologia molecular |
title_short |
The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses |
title_full |
The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses |
title_fullStr |
The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses |
title_full_unstemmed |
The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses |
title_sort |
The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses |
author |
Raquel Virgínia Rocha Vilela |
author_facet |
Raquel Virgínia Rocha Vilela Marianne Huebner Camila Rocha Vilela Gabriella Rocha Vilela Bruno Batista Pettersen Claudia Oliveira Leonel Mendoza |
author_role |
author |
author2 |
Marianne Huebner Camila Rocha Vilela Gabriella Rocha Vilela Bruno Batista Pettersen Claudia Oliveira Leonel Mendoza |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Raquel Virgínia Rocha Vilela Marianne Huebner Camila Rocha Vilela Gabriella Rocha Vilela Bruno Batista Pettersen Claudia Oliveira Leonel Mendoza |
dc.subject.por.fl_str_mv |
Biological techniques Diseases Lacazia Paracoccidioides Ecology Evolution Genetics Medical research Microbiology Molecular biology |
topic |
Biological techniques Diseases Lacazia Paracoccidioides Ecology Evolution Genetics Medical research Microbiology Molecular biology Lacazia Paracoccidioides Ecologia Genética Pesquisa biomédica Microbiologia Biologia molecular |
dc.subject.other.pt_BR.fl_str_mv |
Lacazia Paracoccidioides Ecologia Genética Pesquisa biomédica Microbiologia Biologia molecular |
description |
Ever since the uncultivated South American fungal pathogen Lacazia loboi was first described 90 years ago, its etiology and evolutionary traits have been at the center of endless controversies. This pathogen infects the skin of humans and as long believed, dolphin skin. However, recent DNA analyses of infected dolphins placed its DNA sequences within Paracoccidioides species. This came as a surprise and suggested the human and dolphin pathogens may be different species. In this study, population genetic analyses of DNA from four infected dolphins grouped this pathogen in a monophyletic cluster sister to P. americana and to the other Paracoccidioides species. Based on the results we have emended the taxonomy of the dolphin pathogen as Paracoccidioides cetii and P. loboi the one infecting human. Our data warn that phylogenetic analysis of available taxa without the inclusion of unusual members may provide incomplete information for the accurate classification of anomalous species. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2023-06-01T17:14:38Z |
dc.date.available.fl_str_mv |
2023-06-01T17:14:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/54307 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1038/s41598-021-97429-7 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
url |
https://doi.org/10.1038/s41598-021-97429-7 http://hdl.handle.net/1843/54307 |
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2045-2322 |
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eng |
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eng |
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Scientific reports |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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