Novel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications

Detalhes bibliográficos
Autor(a) principal: Gracielle F. Andrade
Data de Publicação: 2018
Outros Autores: Gesiane da S. Lima, Mirra Angelina Neres da Silva, Edésia M. B. de Sousa, Jacqueline Aparecida Takahashi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.3303/CET1864030
http://hdl.handle.net/1843/59494
https://orcid.org/0000-0002-8831-1609
Resumo: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
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spelling 2023-10-16T21:47:04Z2023-10-16T21:47:04Z201864175180https://doi.org/10.3303/CET18640302283-9216http://hdl.handle.net/1843/59494https://orcid.org/0000-0002-8831-1609CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorCultivation of the fungal species Aspergillus parasiticus led to the isolation of Kojic acid (KA), an important secondary metabolite, but unstable under some conditions. In order to improve the pharmacokinetic potential of KA for biotechnological applications in pharmaceutical and cosmetic formulations, KA was immobilized in mesoporous nanomaterials based on silica (MSN). This kind of inorganic support has been intensively studied as candidates for controlling-release drugs, due to its high surface area, high ordering of mesopores and pore size in nanometer scale. In this way, mesoporous silica nanoparticles have been synthesized and were chemically modified by post-synthesis with 3-aminopropyltriethoxysilane (MSNAPTES) and the influence of functionalization of the matrix on the loading rate of KA was studied. Nanoparticles were physicochemical characterized by SAXS, SEM, CHN, TGA, N2 adsorption, photon correlation spectroscopy and zeta potential analysis. Bactericidal efficacy of these nanoparticles was tested against different microorganisms, and these new kojic acid nanoparticles showed high bactericidal efficiency. In relation to acetylcholinesterase (AChE) inhibition test, used to screen drugs active to treat Alzheimer’s disease patients, MSNAPTES KA nanoparticles showed to be as efficient as the free-acid. KA loading showed also tyrosine inhibitory property preserved. The results points that, although free-kojic acid amount in MSNAPTES KA is thirty times lower, biological activity of this nanoparticle is as high as the activity of free-kojic acid, being, therefore, a highly and multi-active nano-system for kojic acid delivery with improved pharmacokinetic skills and a wide scope of industrial applications.engUniversidade Federal de Minas GeraisUFMGBrasilICX - DEPARTAMENTO DE QUÍMICAChemical Engineering TransactionsMicrobiologiaQuímicaProdutos de ação antimicrobianaMicrobiologiaQuímicaProdutos de ação antimicrobianaNovel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applicationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.aidic.it/cet/18/64/030.pdfGracielle F. AndradeGesiane da S. LimaMirra Angelina Neres da SilvaEdésia M. B. de SousaJacqueline Aparecida Takahashiapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/59494/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALNovel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications.pdfNovel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications.pdfapplication/pdf431743https://repositorio.ufmg.br/bitstream/1843/59494/2/Novel%20Kojic%20Acid-Based%20Functionalized%20Silica%20Nanoparticles%20%20for%20Tyrosinase%20and%20Ache%20Inhibition%20and%20Antimicrobial%20%20Applications.pdf8394a7e6bef212056456d02470caaac2MD521843/594942023-10-16 18:47:04.627oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-10-16T21:47:04Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Novel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications
title Novel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications
spellingShingle Novel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications
Gracielle F. Andrade
Microbiologia
Química
Produtos de ação antimicrobiana
Microbiologia
Química
Produtos de ação antimicrobiana
title_short Novel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications
title_full Novel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications
title_fullStr Novel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications
title_full_unstemmed Novel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications
title_sort Novel Kojic Acid-Based Functionalized Silica Nanoparticles for Tyrosinase and Ache Inhibition and Antimicrobial Applications
author Gracielle F. Andrade
author_facet Gracielle F. Andrade
Gesiane da S. Lima
Mirra Angelina Neres da Silva
Edésia M. B. de Sousa
Jacqueline Aparecida Takahashi
author_role author
author2 Gesiane da S. Lima
Mirra Angelina Neres da Silva
Edésia M. B. de Sousa
Jacqueline Aparecida Takahashi
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gracielle F. Andrade
Gesiane da S. Lima
Mirra Angelina Neres da Silva
Edésia M. B. de Sousa
Jacqueline Aparecida Takahashi
dc.subject.por.fl_str_mv Microbiologia
Química
Produtos de ação antimicrobiana
topic Microbiologia
Química
Produtos de ação antimicrobiana
Microbiologia
Química
Produtos de ação antimicrobiana
dc.subject.other.pt_BR.fl_str_mv Microbiologia
Química
Produtos de ação antimicrobiana
description CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2023-10-16T21:47:04Z
dc.date.available.fl_str_mv 2023-10-16T21:47:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/59494
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.3303/CET1864030
dc.identifier.issn.pt_BR.fl_str_mv 2283-9216
dc.identifier.orcid.pt_BR.fl_str_mv https://orcid.org/0000-0002-8831-1609
url https://doi.org/10.3303/CET1864030
http://hdl.handle.net/1843/59494
https://orcid.org/0000-0002-8831-1609
identifier_str_mv 2283-9216
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Chemical Engineering Transactions
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv ICX - DEPARTAMENTO DE QUÍMICA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/59494/1/License.txt
https://repositorio.ufmg.br/bitstream/1843/59494/2/Novel%20Kojic%20Acid-Based%20Functionalized%20Silica%20Nanoparticles%20%20for%20Tyrosinase%20and%20Ache%20Inhibition%20and%20Antimicrobial%20%20Applications.pdf
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