Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | http://dx.doi.org/10.1590/s2175-97902020000418497 http://hdl.handle.net/1843/52599 https://orcid.org/0000-0002-7360-8231 https://orcid.org/0000-0002-0539-9052 https://orcid.org/0000-0003-2474-5536 https://orcid.org/0000-0002-1933-3230 https://orcid.org/0000-0002-8703-4283 https://orcid.org/0000-0001-7714-991X https://orcid.org/0000-0002-0412-1622 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| id |
UFMG_abb7c4b28782f595b364bc73636437eb |
|---|---|
| oai_identifier_str |
oai:repositorio.ufmg.br:1843/52599 |
| network_acronym_str |
UFMG |
| network_name_str |
Repositório Institucional da UFMG |
| repository_id_str |
|
| spelling |
2023-04-27T18:25:50Z2023-04-27T18:25:50Z202157115http://dx.doi.org/10.1590/s2175-979020200004184972175-9790http://hdl.handle.net/1843/52599https://orcid.org/0000-0002-7360-8231https://orcid.org/0000-0002-0539-9052https://orcid.org/0000-0003-2474-5536https://orcid.org/0000-0002-1933-3230https://orcid.org/0000-0002-8703-4283https://orcid.org/0000-0001-7714-991Xhttps://orcid.org/0000-0002-0412-1622CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorSclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN-SC) and nanostructured lipid carriers (NLC-SC) loaded with SC were produced and compared regarding their physicochemical properties. NLC-SC showed better SC encapsulation than SLN-SC and was chosen to be compared with free SC in human cancer cell lines (MDA-MB-231 and HCT-116). Free SC had slightly higher cytotoxicity than NLC-SC and produced subdiploid DNA content in both cell lines. On the other hand, NLC-SC led to subdiploid content in MDA-MB-231 cells and G2/M checkpoint arrest in HCT-116 cells. These findings suggest that SC encapsulation in NLC is a way to allow the in vivo administration of SC and might alter its biological properties.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICAICX - DEPARTAMENTO DE FÍSICABrazilian Journal of Pharmaceutical SciencesCâncerNanopartículasLipídiosCancerSclareolSolid lipid nanoparticlesNanostructured lipid carriersSmall-angle X-ray scatteringNanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell linesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/bjps/a/hrgfv38NNnJqwvqXtQVG9Dv/?lang=enGabriel Silva Marques BorgesElaine Maria de Souza FagundesLucas Antônio Miranda FerreiraPedro Henrique Dias Moura PrazeresÂngelo Malachias de SouzaMaria Irene YoshidaJosé Mário Carneiro VilelaAline Teixeira Maciel e SilvaMariana Silva OliveiraDawidson Assis GomesMargareth Spangler Andradeapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/52599/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALNanostructured lipid carriers as a novel tool to.pdfNanostructured lipid carriers as a novel tool to.pdfapplication/pdf1455172https://repositorio.ufmg.br/bitstream/1843/52599/2/Nanostructured%20lipid%20carriers%20as%20a%20novel%20tool%20to.pdf7312cf01e03fff933ade3f22e8d3651eMD521843/525992023-04-27 16:16:48.075oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-04-27T19:16:48Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines |
| title |
Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines |
| spellingShingle |
Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines Gabriel Silva Marques Borges Cancer Sclareol Solid lipid nanoparticles Nanostructured lipid carriers Small-angle X-ray scattering Câncer Nanopartículas Lipídios |
| title_short |
Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines |
| title_full |
Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines |
| title_fullStr |
Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines |
| title_full_unstemmed |
Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines |
| title_sort |
Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines |
| author |
Gabriel Silva Marques Borges |
| author_facet |
Gabriel Silva Marques Borges Elaine Maria de Souza Fagundes Lucas Antônio Miranda Ferreira Pedro Henrique Dias Moura Prazeres Ângelo Malachias de Souza Maria Irene Yoshida José Mário Carneiro Vilela Aline Teixeira Maciel e Silva Mariana Silva Oliveira Dawidson Assis Gomes Margareth Spangler Andrade |
| author_role |
author |
| author2 |
Elaine Maria de Souza Fagundes Lucas Antônio Miranda Ferreira Pedro Henrique Dias Moura Prazeres Ângelo Malachias de Souza Maria Irene Yoshida José Mário Carneiro Vilela Aline Teixeira Maciel e Silva Mariana Silva Oliveira Dawidson Assis Gomes Margareth Spangler Andrade |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gabriel Silva Marques Borges Elaine Maria de Souza Fagundes Lucas Antônio Miranda Ferreira Pedro Henrique Dias Moura Prazeres Ângelo Malachias de Souza Maria Irene Yoshida José Mário Carneiro Vilela Aline Teixeira Maciel e Silva Mariana Silva Oliveira Dawidson Assis Gomes Margareth Spangler Andrade |
| dc.subject.por.fl_str_mv |
Cancer Sclareol Solid lipid nanoparticles Nanostructured lipid carriers Small-angle X-ray scattering |
| topic |
Cancer Sclareol Solid lipid nanoparticles Nanostructured lipid carriers Small-angle X-ray scattering Câncer Nanopartículas Lipídios |
| dc.subject.other.pt_BR.fl_str_mv |
Câncer Nanopartículas Lipídios |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2021 |
| dc.date.issued.fl_str_mv |
2021 |
| dc.date.accessioned.fl_str_mv |
2023-04-27T18:25:50Z |
| dc.date.available.fl_str_mv |
2023-04-27T18:25:50Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/52599 |
| dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.1590/s2175-97902020000418497 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2175-9790 |
| dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-7360-8231 https://orcid.org/0000-0002-0539-9052 https://orcid.org/0000-0003-2474-5536 https://orcid.org/0000-0002-1933-3230 https://orcid.org/0000-0002-8703-4283 https://orcid.org/0000-0001-7714-991X https://orcid.org/0000-0002-0412-1622 |
| url |
http://dx.doi.org/10.1590/s2175-97902020000418497 http://hdl.handle.net/1843/52599 https://orcid.org/0000-0002-7360-8231 https://orcid.org/0000-0002-0539-9052 https://orcid.org/0000-0003-2474-5536 https://orcid.org/0000-0002-1933-3230 https://orcid.org/0000-0002-8703-4283 https://orcid.org/0000-0001-7714-991X https://orcid.org/0000-0002-0412-1622 |
| identifier_str_mv |
2175-9790 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
| dc.publisher.initials.fl_str_mv |
UFMG |
| dc.publisher.country.fl_str_mv |
Brasil |
| dc.publisher.department.fl_str_mv |
ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICX - DEPARTAMENTO DE FÍSICA |
| publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
| instname_str |
Universidade Federal de Minas Gerais (UFMG) |
| instacron_str |
UFMG |
| institution |
UFMG |
| reponame_str |
Repositório Institucional da UFMG |
| collection |
Repositório Institucional da UFMG |
| bitstream.url.fl_str_mv |
https://repositorio.ufmg.br/bitstream/1843/52599/1/License.txt https://repositorio.ufmg.br/bitstream/1843/52599/2/Nanostructured%20lipid%20carriers%20as%20a%20novel%20tool%20to.pdf |
| bitstream.checksum.fl_str_mv |
fa505098d172de0bc8864fc1287ffe22 7312cf01e03fff933ade3f22e8d3651e |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
| repository.mail.fl_str_mv |
|
| _version_ |
1801676607142756352 |