Comparison of inflammatory mediators in patients with atrial fibrillation using warfarin or rivaroxaban
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.3389/fcvm.2020.00114 http://hdl.handle.net/1843/47142 |
Resumo: | Background: Atrial fibrillation (AF) is the most common arrhythmia associated with high risk of venous thromboembolism. Inflammatory mechanisms may be involved in the pathophysiology of AF and in the AF-related thrombogenesis, and patients with AF might benefit from the use of anticoagulants with anti-inflammatory properties. However, the evidence is still scarce, and it points out the need of trials seeking to investigate the levels of inflammatory mediators in patients with AF under different anticoagulant therapies. Therefore, this study was designed to define whether patients with AF treated either with an activated coagulation factor X (FXa) inhibitor (rivaroxaban) or with a vitamin K inhibitor (warfarin) present changes in peripheral levels of inflammatory mediators, mainly cytokines and chemokines. Methods: A total of 127 subjects were included in this study, divided into three groups: patients with non-valvular atrial fibrillation (NVAF) using warfarin (N = 42), patients with NVAF using rivaroxaban (N = 29), and controls (N = 56). Plasma levels of inflammatory mediators were quantified by immunoassays. Results: Patients with AF (both warfarin and rivaroxaban groups) presented increased levels of inflammatory cytokines in comparison with controls. The use of rivaroxaban was associated with decreased levels of inflammatory cytokines in comparison with warfarin. On the other hand, patients with AF using rivaroxaban presented increased levels of the chemokines (MCP-1 in comparison with warfarin users; MIG and IP-10 in comparison with controls). Conclusions: AF is associated with an inflammatory profile that was less pronounced in patients on rivaroxaban in comparison with warfarin users. Further studies are necessary to assess the clinical implications of our results and whether patients with AF would benefit from rivaroxaban anti-inflammatory effects. |
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2022-11-10T19:17:13Z2022-11-10T19:17:13Z2020-07-24711418https://doi.org/10.3389/fcvm.2020.001142297-055Xhttp://hdl.handle.net/1843/47142Background: Atrial fibrillation (AF) is the most common arrhythmia associated with high risk of venous thromboembolism. Inflammatory mechanisms may be involved in the pathophysiology of AF and in the AF-related thrombogenesis, and patients with AF might benefit from the use of anticoagulants with anti-inflammatory properties. However, the evidence is still scarce, and it points out the need of trials seeking to investigate the levels of inflammatory mediators in patients with AF under different anticoagulant therapies. Therefore, this study was designed to define whether patients with AF treated either with an activated coagulation factor X (FXa) inhibitor (rivaroxaban) or with a vitamin K inhibitor (warfarin) present changes in peripheral levels of inflammatory mediators, mainly cytokines and chemokines. Methods: A total of 127 subjects were included in this study, divided into three groups: patients with non-valvular atrial fibrillation (NVAF) using warfarin (N = 42), patients with NVAF using rivaroxaban (N = 29), and controls (N = 56). Plasma levels of inflammatory mediators were quantified by immunoassays. Results: Patients with AF (both warfarin and rivaroxaban groups) presented increased levels of inflammatory cytokines in comparison with controls. The use of rivaroxaban was associated with decreased levels of inflammatory cytokines in comparison with warfarin. On the other hand, patients with AF using rivaroxaban presented increased levels of the chemokines (MCP-1 in comparison with warfarin users; MIG and IP-10 in comparison with controls). Conclusions: AF is associated with an inflammatory profile that was less pronounced in patients on rivaroxaban in comparison with warfarin users. Further studies are necessary to assess the clinical implications of our results and whether patients with AF would benefit from rivaroxaban anti-inflammatory effects.Fundamento: A fibrilação atrial (FA) é a arritmia mais comum associada ao alto risco de tromboembolismo venoso. Mecanismos inflamatórios podem estar envolvidos na fisiopatologia da FA e na trombogênese relacionada à FA, e pacientes com FA podem se beneficiar do uso de anticoagulantes com propriedades anti-inflamatórias. No entanto, as evidências ainda são escassas e apontam para a necessidade de estudos que busquem investigar os níveis de mediadores inflamatórios em pacientes com FA sob diferentes terapias anticoagulantes. Portanto, este estudo foi desenhado para definir se pacientes com FA tratados com um inibidor do fator de coagulação X ativado (FXa) (rivaroxabana) ou com um inibidor da vitamina K (varfarina) apresentam alterações nos níveis periféricos de mediadores inflamatórios, principalmente citocinas e quimiocinas. Métodos: Um total de 127 indivíduos foram incluídos neste estudo, divididos em três grupos: pacientes com fibrilação atrial não valvar (FANV) em uso de varfarina (N = 42), pacientes com FANV em uso de rivaroxabana (N = 29) e controles ( N = 56). Os níveis plasmáticos de mediadores inflamatórios foram quantificados por imunoensaios. Resultados: Pacientes com FA (grupos varfarina e rivaroxabana) apresentaram níveis aumentados de citocinas inflamatórias em comparação aos controles. O uso de rivaroxabana foi associado à diminuição dos níveis de citocinas inflamatórias em comparação com a varfarina. Por outro lado, pacientes com FA em uso de rivaroxabana apresentaram níveis aumentados das quimiocinas (MCP-1 em comparação com usuários de varfarina; MIG e IP-10 em comparação com controles). Conclusões: A FA está associada a um perfil inflamatório menos pronunciado nos pacientes em uso de rivaroxabana em comparação aos usuários de varfarina. Mais estudos são necessários para avaliar as implicações clínicas de nossos resultados e se os pacientes com FA se beneficiariam dos efeitos anti-inflamatórios da rivaroxabana.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE FARMACOLOGIAFrontiers in Cardiovascular MedicineFibrilação atrialArritmias cardíacasAnti-inflamatóriosAnticoagulantesVarfarinaRivaroxabanaAtrial fibrillationArrhythmias, cardiacAnti-inflammatory agentsAnticoagulantsWarfarinRivaroxabanComparison of inflammatory mediators in patients with atrial fibrillation using warfarin or rivaroxabaninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/articles/10.3389/fcvm.2020.00114/fullGabriela Lopes MartinsRita Carolina Figueiredo DuarteÉrica Leandro Marciano VieiraNatalia Pessoa RochaEstêvão Lanna FigueiredoFrancisco Rezende SilveiraJosé Raymundo Sollero CaiaffaRodrigo Pinheiro LannaMaria das Graças CarvalhoAndrás PalotásCláudia Natália FerreiraHelton José dos Reisapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Comparison of inflammatory mediators in patients with atrial fibrillation using warfarin or rivaroxaban |
title |
Comparison of inflammatory mediators in patients with atrial fibrillation using warfarin or rivaroxaban |
spellingShingle |
Comparison of inflammatory mediators in patients with atrial fibrillation using warfarin or rivaroxaban Gabriela Lopes Martins Atrial fibrillation Arrhythmias, cardiac Anti-inflammatory agents Anticoagulants Warfarin Rivaroxaban Fibrilação atrial Arritmias cardíacas Anti-inflamatórios Anticoagulantes Varfarina Rivaroxabana |
title_short |
Comparison of inflammatory mediators in patients with atrial fibrillation using warfarin or rivaroxaban |
title_full |
Comparison of inflammatory mediators in patients with atrial fibrillation using warfarin or rivaroxaban |
title_fullStr |
Comparison of inflammatory mediators in patients with atrial fibrillation using warfarin or rivaroxaban |
title_full_unstemmed |
Comparison of inflammatory mediators in patients with atrial fibrillation using warfarin or rivaroxaban |
title_sort |
Comparison of inflammatory mediators in patients with atrial fibrillation using warfarin or rivaroxaban |
author |
Gabriela Lopes Martins |
author_facet |
Gabriela Lopes Martins Rita Carolina Figueiredo Duarte Érica Leandro Marciano Vieira Natalia Pessoa Rocha Estêvão Lanna Figueiredo Francisco Rezende Silveira José Raymundo Sollero Caiaffa Rodrigo Pinheiro Lanna Maria das Graças Carvalho András Palotás Cláudia Natália Ferreira Helton José dos Reis |
author_role |
author |
author2 |
Rita Carolina Figueiredo Duarte Érica Leandro Marciano Vieira Natalia Pessoa Rocha Estêvão Lanna Figueiredo Francisco Rezende Silveira José Raymundo Sollero Caiaffa Rodrigo Pinheiro Lanna Maria das Graças Carvalho András Palotás Cláudia Natália Ferreira Helton José dos Reis |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gabriela Lopes Martins Rita Carolina Figueiredo Duarte Érica Leandro Marciano Vieira Natalia Pessoa Rocha Estêvão Lanna Figueiredo Francisco Rezende Silveira José Raymundo Sollero Caiaffa Rodrigo Pinheiro Lanna Maria das Graças Carvalho András Palotás Cláudia Natália Ferreira Helton José dos Reis |
dc.subject.por.fl_str_mv |
Atrial fibrillation Arrhythmias, cardiac Anti-inflammatory agents Anticoagulants Warfarin Rivaroxaban |
topic |
Atrial fibrillation Arrhythmias, cardiac Anti-inflammatory agents Anticoagulants Warfarin Rivaroxaban Fibrilação atrial Arritmias cardíacas Anti-inflamatórios Anticoagulantes Varfarina Rivaroxabana |
dc.subject.other.pt_BR.fl_str_mv |
Fibrilação atrial Arritmias cardíacas Anti-inflamatórios Anticoagulantes Varfarina Rivaroxabana |
description |
Background: Atrial fibrillation (AF) is the most common arrhythmia associated with high risk of venous thromboembolism. Inflammatory mechanisms may be involved in the pathophysiology of AF and in the AF-related thrombogenesis, and patients with AF might benefit from the use of anticoagulants with anti-inflammatory properties. However, the evidence is still scarce, and it points out the need of trials seeking to investigate the levels of inflammatory mediators in patients with AF under different anticoagulant therapies. Therefore, this study was designed to define whether patients with AF treated either with an activated coagulation factor X (FXa) inhibitor (rivaroxaban) or with a vitamin K inhibitor (warfarin) present changes in peripheral levels of inflammatory mediators, mainly cytokines and chemokines. Methods: A total of 127 subjects were included in this study, divided into three groups: patients with non-valvular atrial fibrillation (NVAF) using warfarin (N = 42), patients with NVAF using rivaroxaban (N = 29), and controls (N = 56). Plasma levels of inflammatory mediators were quantified by immunoassays. Results: Patients with AF (both warfarin and rivaroxaban groups) presented increased levels of inflammatory cytokines in comparison with controls. The use of rivaroxaban was associated with decreased levels of inflammatory cytokines in comparison with warfarin. On the other hand, patients with AF using rivaroxaban presented increased levels of the chemokines (MCP-1 in comparison with warfarin users; MIG and IP-10 in comparison with controls). Conclusions: AF is associated with an inflammatory profile that was less pronounced in patients on rivaroxaban in comparison with warfarin users. Further studies are necessary to assess the clinical implications of our results and whether patients with AF would benefit from rivaroxaban anti-inflammatory effects. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-07-24 |
dc.date.accessioned.fl_str_mv |
2022-11-10T19:17:13Z |
dc.date.available.fl_str_mv |
2022-11-10T19:17:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/47142 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3389/fcvm.2020.00114 |
dc.identifier.issn.pt_BR.fl_str_mv |
2297-055X |
url |
https://doi.org/10.3389/fcvm.2020.00114 http://hdl.handle.net/1843/47142 |
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2297-055X |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in Cardiovascular Medicine |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE FARMACOLOGIA |
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Universidade Federal de Minas Gerais |
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