Benefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.jtcme.2021.11.002 http://hdl.handle.net/1843/56260 https://orcid.org/0000-0002-2046-3518 https://orcid.org/0000-0003-0620-2984 https://orcid.org/0000-0002-7203-6729 https://orcid.org/0000-0002-3496-6749 https://orcid.org/0000-0002-6832-2765 |
Resumo: | Background and aim: Osteoarthritis (OA) is characterized by pain and inflammation. Electroacupuncture (EA) and swimming (SW) are non-pharmacological interventions recommended for treating OA. The study evaluated the benefits of electroacupuncture (EA) and swimming (SW) association when compared with isolated protocols in an OA rodent model. Experimental. Procedures: An ankle monoarthritis model was induced in rats by applying Complete Freund's Adjuvant (CFA). After seven days of induced OA, the groups were submitted to EA (ST36 and the GB 30 Acupoint), SW, or the EA þ SW protocol. The nociceptive behavior was measured by the Von Frey test, the Cold Stimulation test, and the Paw Flick Immersion test. Inflammatory activity was evaluated by measuring TNF levels, myeloperoxidase, NAGase, immunological parameters and the histology from the subcutaneous tissue. Results: Compared to CFA group, EA decreased the nociceptive scores in the cold stimulation test (p < 0.05), and it also increased the latency time in thermal cold (p < 0.01) and heat hyperalgesia (p < 0.001). Also, EA reduced NAGase (p < 0.01). SW reduced the edema (p < 0.05) and did not increase the inflammatory infiltrates or congestion, neither in the histological measurements nor by analyzing the levels of TNF. The association of EA þ SW decreased the neutrophils and the monocytes, MPO (p < 0.05), and the glutamate levels in the cerebrospinal fluid (CSF, p < 0.001). Conclusion: There were statistical differences between combination therapy and monotherapy as seen by the inflammatory parameters, which could be associate to the delay of the chronification osteoarthritis retardation. However, EA þ SW did not show benefits when compared to isolated protocols in nociceptive behavior. |
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2023-07-14T19:50:52Z2023-07-14T19:50:52Z2022-07124375383https://doi.org/10.1016/j.jtcme.2021.11.0022225-4110http://hdl.handle.net/1843/56260https://orcid.org/0000-0002-2046-3518https://orcid.org/0000-0003-0620-2984https://orcid.org/0000-0002-7203-6729https://orcid.org/0000-0002-3496-6749https://orcid.org/0000-0002-6832-2765Background and aim: Osteoarthritis (OA) is characterized by pain and inflammation. Electroacupuncture (EA) and swimming (SW) are non-pharmacological interventions recommended for treating OA. The study evaluated the benefits of electroacupuncture (EA) and swimming (SW) association when compared with isolated protocols in an OA rodent model. Experimental. Procedures: An ankle monoarthritis model was induced in rats by applying Complete Freund's Adjuvant (CFA). After seven days of induced OA, the groups were submitted to EA (ST36 and the GB 30 Acupoint), SW, or the EA þ SW protocol. The nociceptive behavior was measured by the Von Frey test, the Cold Stimulation test, and the Paw Flick Immersion test. Inflammatory activity was evaluated by measuring TNF levels, myeloperoxidase, NAGase, immunological parameters and the histology from the subcutaneous tissue. Results: Compared to CFA group, EA decreased the nociceptive scores in the cold stimulation test (p < 0.05), and it also increased the latency time in thermal cold (p < 0.01) and heat hyperalgesia (p < 0.001). Also, EA reduced NAGase (p < 0.01). SW reduced the edema (p < 0.05) and did not increase the inflammatory infiltrates or congestion, neither in the histological measurements nor by analyzing the levels of TNF. The association of EA þ SW decreased the neutrophils and the monocytes, MPO (p < 0.05), and the glutamate levels in the cerebrospinal fluid (CSF, p < 0.001). Conclusion: There were statistical differences between combination therapy and monotherapy as seen by the inflammatory parameters, which could be associate to the delay of the chronification osteoarthritis retardation. However, EA þ SW did not show benefits when compared to isolated protocols in nociceptive behavior.Justificativa e objetivo: A osteoartrite (OA) é caracterizada por dor e inflamação. A eletroacupuntura (EA) e a natação (SW) são intervenções não farmacológicas recomendadas para o tratamento da OA. O estudo avaliou os benefícios da associação de eletroacupuntura (EA) e natação (SW) quando comparada com protocolos isolados em um modelo de roedor OA. Experimental. Procedimentos: Um modelo de monoartrite de tornozelo foi induzido em ratos pela aplicação de Adjuvante Completo de Freund (CFA). Após sete dias de OA induzida, os grupos foram submetidos ao protocolo EA (ST36 e GB 30 Acupoint), SW ou protocolo EA þ SW. O comportamento nociceptivo foi medido pelo teste de Von Frey, pelo teste Cold Stimulation e pelo teste Paw Flick Immersion. A atividade inflamatória foi avaliada pela dosagem de TNF, mieloperoxidase, NAGase, parâmetros imunológicos e histologia do tecido subcutâneo. Resultados: Comparado ao grupo CFA, o EA diminuiu os escores nociceptivos no teste de estimulação ao frio (p < 0,05) e também aumentou o tempo de latência no frio térmico (p < 0,01) e na hiperalgesia ao calor (p < 0,001). Além disso, EA reduziu NAGase (p < 0,01). SW reduziu o edema (p < 0,05) e não aumentou os infiltrados inflamatórios ou congestão, nem nas medidas histológicas nem na análise dos níveis de TNF. A associação EA + SW diminuiu os neutrófilos e os monócitos, MPO (p < 0,05) e os níveis de glutamato no líquido cefalorraquidiano (LCR, p < 0,001). Conclusão: Houve diferenças estatísticas entre terapia combinada e monoterapia quanto aos parâmetros inflamatórios, o que pode estar associado ao retardo da cronificação da osteoartrite. No entanto, EA þ SW não apresentou benefícios quando comparado a protocolos isolados no comportamento nociceptivo.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE FARMACOLOGIAJournal of Traditional and Complementary MedicineOsteoartriteManejo da dorEletroacupunturaNataçãoOsteoarthritisPain behaviorElectroacupunctureSwimmingNon-pharmacological approachesBenefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis modelBenefícios da eletroacupuntura e da associação de natação em comparação com protocolos isolados em modelo de osteoartriteinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S2225411021001371?via%3DihubGustavo Andrade MartinsAndressa Nayara DegenFlavia Tasmin Techera AntunesLuiza Gabriela da RosaAlice Gomez FerrazElenir de Fátima WiillandLuciene Bruno VieiraAlessandra Hubner de Souzaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56260/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALBenefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model.pdfBenefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model.pdfapplication/pdf2240177https://repositorio.ufmg.br/bitstream/1843/56260/2/Benefits%20of%20electroacupuncture%20and%20a%20swimming%20association%20when%20compared%20with%20isolated%20protocols%20in%20an%20osteoarthritis%20model.pdfce1bf20b91599c076ddba3e6def48623MD521843/562602023-07-14 16:50:53.012oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-14T19:50:53Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Benefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model |
dc.title.alternative.pt_BR.fl_str_mv |
Benefícios da eletroacupuntura e da associação de natação em comparação com protocolos isolados em modelo de osteoartrite |
title |
Benefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model |
spellingShingle |
Benefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model Gustavo Andrade Martins Osteoarthritis Pain behavior Electroacupuncture Swimming Non-pharmacological approaches Osteoartrite Manejo da dor Eletroacupuntura Natação |
title_short |
Benefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model |
title_full |
Benefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model |
title_fullStr |
Benefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model |
title_full_unstemmed |
Benefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model |
title_sort |
Benefits of electroacupuncture and a swimming association when compared with isolated protocols in an osteoarthritis model |
author |
Gustavo Andrade Martins |
author_facet |
Gustavo Andrade Martins Andressa Nayara Degen Flavia Tasmin Techera Antunes Luiza Gabriela da Rosa Alice Gomez Ferraz Elenir de Fátima Wiilland Luciene Bruno Vieira Alessandra Hubner de Souza |
author_role |
author |
author2 |
Andressa Nayara Degen Flavia Tasmin Techera Antunes Luiza Gabriela da Rosa Alice Gomez Ferraz Elenir de Fátima Wiilland Luciene Bruno Vieira Alessandra Hubner de Souza |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Gustavo Andrade Martins Andressa Nayara Degen Flavia Tasmin Techera Antunes Luiza Gabriela da Rosa Alice Gomez Ferraz Elenir de Fátima Wiilland Luciene Bruno Vieira Alessandra Hubner de Souza |
dc.subject.por.fl_str_mv |
Osteoarthritis Pain behavior Electroacupuncture Swimming Non-pharmacological approaches |
topic |
Osteoarthritis Pain behavior Electroacupuncture Swimming Non-pharmacological approaches Osteoartrite Manejo da dor Eletroacupuntura Natação |
dc.subject.other.pt_BR.fl_str_mv |
Osteoartrite Manejo da dor Eletroacupuntura Natação |
description |
Background and aim: Osteoarthritis (OA) is characterized by pain and inflammation. Electroacupuncture (EA) and swimming (SW) are non-pharmacological interventions recommended for treating OA. The study evaluated the benefits of electroacupuncture (EA) and swimming (SW) association when compared with isolated protocols in an OA rodent model. Experimental. Procedures: An ankle monoarthritis model was induced in rats by applying Complete Freund's Adjuvant (CFA). After seven days of induced OA, the groups were submitted to EA (ST36 and the GB 30 Acupoint), SW, or the EA þ SW protocol. The nociceptive behavior was measured by the Von Frey test, the Cold Stimulation test, and the Paw Flick Immersion test. Inflammatory activity was evaluated by measuring TNF levels, myeloperoxidase, NAGase, immunological parameters and the histology from the subcutaneous tissue. Results: Compared to CFA group, EA decreased the nociceptive scores in the cold stimulation test (p < 0.05), and it also increased the latency time in thermal cold (p < 0.01) and heat hyperalgesia (p < 0.001). Also, EA reduced NAGase (p < 0.01). SW reduced the edema (p < 0.05) and did not increase the inflammatory infiltrates or congestion, neither in the histological measurements nor by analyzing the levels of TNF. The association of EA þ SW decreased the neutrophils and the monocytes, MPO (p < 0.05), and the glutamate levels in the cerebrospinal fluid (CSF, p < 0.001). Conclusion: There were statistical differences between combination therapy and monotherapy as seen by the inflammatory parameters, which could be associate to the delay of the chronification osteoarthritis retardation. However, EA þ SW did not show benefits when compared to isolated protocols in nociceptive behavior. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022-07 |
dc.date.accessioned.fl_str_mv |
2023-07-14T19:50:52Z |
dc.date.available.fl_str_mv |
2023-07-14T19:50:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
status_str |
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dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56260 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.jtcme.2021.11.002 |
dc.identifier.issn.pt_BR.fl_str_mv |
2225-4110 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-2046-3518 https://orcid.org/0000-0003-0620-2984 https://orcid.org/0000-0002-7203-6729 https://orcid.org/0000-0002-3496-6749 https://orcid.org/0000-0002-6832-2765 |
url |
https://doi.org/10.1016/j.jtcme.2021.11.002 http://hdl.handle.net/1843/56260 https://orcid.org/0000-0002-2046-3518 https://orcid.org/0000-0003-0620-2984 https://orcid.org/0000-0002-7203-6729 https://orcid.org/0000-0002-3496-6749 https://orcid.org/0000-0002-6832-2765 |
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2225-4110 |
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eng |
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eng |
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Journal of Traditional and Complementary Medicine |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICB - DEPARTAMENTO DE FARMACOLOGIA |
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Universidade Federal de Minas Gerais |
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