The curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines: double-blind crossover study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.3390/biology11040573 http://hdl.handle.net/1843/60277 https://orcid.org/0000-0001-7590-9129 https://orcid.org/0000-0003-3817-3858 https://orcid.org/0000-0002-1772-1272 https://orcid.org/0000-0001-9813-2842 https://orcid.org/0000-0001-7378-4529 https://orcid.org/0000-0003-2485-5137 https://orcid.org/0000-0003-3914-0062 https://orcid.org/0000-0002-4243-0266 https://orcid.org/0000-0002-1183-7610 https://orcid.org/0000-0001-9222-3882 |
Resumo: | Background: to evaluate the effects of one week of supplementation with curcumin combined with piperine on physical performance, immune system cell counts, muscle damage, and plasma levels of inflammatory markers after a treadmill running training session. Methods: This study is a double-blind, crossover-balanced clinical trial with a three-week intervention. Sixteen male runners with a mean age of 36 ± 9 years and VO2 max of 60.6 ± 9.03 mL.kg −1 min −1 were recruited and randomly divided into 2 groups: the first group (CPG) was supplemented daily for 7 days with 500 mg of curcumin + 20 mg piperine, and the second group (PG) was supplemented with 540 mg of cellulose. After the 7th day of supplementation, the volunteers participated in the experimental running protocol, where blood samples were collected before, after, and one hour after exercise for analysis of the number of leukocytes, creatine kinase, and cytokine concentration (IL-2, TNF-α, IFN, IL-6, and IL-10) using flow cytometry. This process was repeated, reversing the supplementation offered to the groups. Results: curcumin and piperine supplementation could not change the physical performance, immune cell counts, and muscle damage; however, the aerobic fatiguing exercise protocol inhibited the elevation of the plasmatic levels of some cytokines. The running exercise protocol could elevate the circulating levels of IL-2 (from 49.7 to 59.3 pg/mL), TNF-α (from 48.5 to 51.5 pg/mL), INF (from 128.8 to 165.0 pg/mL), IL-6 (from 63.1 to 77.3 pg/mL), and IL-10 (from 48.9 to 59.6 pg/mL) 1 h after the end of the running protocol. However, the curcumin and piperine supplementation could inhibit this elevation. Conclusions: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-α, INF, IL-6, and IL-10 1 h after the end of exercise. |
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2023-10-30T21:01:12Z2023-10-30T21:01:12Z202211411https://doi.org/10.3390/biology110405732079-7737http://hdl.handle.net/1843/60277https://orcid.org/0000-0001-7590-9129https://orcid.org/0000-0003-3817-3858https://orcid.org/0000-0002-1772-1272https://orcid.org/0000-0001-9813-2842https://orcid.org/0000-0001-7378-4529https://orcid.org/0000-0003-2485-5137https://orcid.org/0000-0003-3914-0062https://orcid.org/0000-0002-4243-0266https://orcid.org/0000-0002-1183-7610https://orcid.org/0000-0001-9222-3882Background: to evaluate the effects of one week of supplementation with curcumin combined with piperine on physical performance, immune system cell counts, muscle damage, and plasma levels of inflammatory markers after a treadmill running training session. Methods: This study is a double-blind, crossover-balanced clinical trial with a three-week intervention. Sixteen male runners with a mean age of 36 ± 9 years and VO2 max of 60.6 ± 9.03 mL.kg −1 min −1 were recruited and randomly divided into 2 groups: the first group (CPG) was supplemented daily for 7 days with 500 mg of curcumin + 20 mg piperine, and the second group (PG) was supplemented with 540 mg of cellulose. After the 7th day of supplementation, the volunteers participated in the experimental running protocol, where blood samples were collected before, after, and one hour after exercise for analysis of the number of leukocytes, creatine kinase, and cytokine concentration (IL-2, TNF-α, IFN, IL-6, and IL-10) using flow cytometry. This process was repeated, reversing the supplementation offered to the groups. Results: curcumin and piperine supplementation could not change the physical performance, immune cell counts, and muscle damage; however, the aerobic fatiguing exercise protocol inhibited the elevation of the plasmatic levels of some cytokines. The running exercise protocol could elevate the circulating levels of IL-2 (from 49.7 to 59.3 pg/mL), TNF-α (from 48.5 to 51.5 pg/mL), INF (from 128.8 to 165.0 pg/mL), IL-6 (from 63.1 to 77.3 pg/mL), and IL-10 (from 48.9 to 59.6 pg/mL) 1 h after the end of the running protocol. However, the curcumin and piperine supplementation could inhibit this elevation. Conclusions: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-α, INF, IL-6, and IL-10 1 h after the end of exercise.Antecedentes: avaliar os efeitos de uma semana de suplementação com curcumina combinada com piperina no desempenho físico, contagem de células do sistema imunológico, dano muscular e níveis plasmáticos de marcadores inflamatórios após uma sessão de treinamento de corrida em esteira. Métodos: Este estudo é um ensaio clínico duplo-cego, cruzado e balanceado com intervenção de três semanas. Dezesseis corredores do sexo masculino, com idade média de 36 ± 9 anos e VO2 máx de 60,6 ± 9,03 mL.kg −1 min −1 foram recrutados e divididos aleatoriamente em 2 grupos: o primeiro grupo (CPG) foi suplementado diariamente durante 7 dias com 500 mg de curcumina + 20 mg de piperina, e o segundo grupo (GP) foi suplementado com 540 mg de celulose. Após o 7º dia de suplementação, os voluntários participaram do protocolo de corrida experimental, onde foram coletadas amostras de sangue antes, depois e uma hora após o exercício para análise do número de leucócitos, creatina quinase e concentração de citocinas (IL-2, TNF). -α, IFN, IL-6 e IL-10) usando citometria de fluxo. Esse processo foi repetido, invertendo a suplementação oferecida aos grupos. Resultados: a suplementação de curcumina e piperina não alterou o desempenho físico, a contagem de células imunológicas e os danos musculares; entretanto, o protocolo de exercícios aeróbicos fatigantes inibiu a elevação dos níveis plasmáticos de algumas citocinas. O protocolo de exercício de corrida poderia elevar os níveis circulantes de IL-2 (de 49,7 para 59,3 pg/mL), TNF-α (de 48,5 para 51,5 pg/mL), INF (de 128,8 para 165,0 pg/mL), IL-6 (de 63,1 a 77,3 pg/mL) e IL-10 (de 48,9 a 59,6 pg/mL) 1h após o término do protocolo de corrida. No entanto, a suplementação de curcumina e piperina poderia inibir esta elevação. Conclusões: a suplementação de curcumina e piperina não teve efeito no desempenho físico, na contagem de células imunológicas ou nos danos musculares; entretanto, a suplementação poderia modular a cinética de IL-2, TNF-α, INF, IL-6 e IL-10 1 hora após o término do exercício.Outra AgênciaporUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE PEDIATRIABiologyCurcuminaInflamaçãoCorridaSuplementos nutricionaisCurcuminInflammationRunningDietary supplementsThe curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines: double-blind crossover studyA suplementação de curcumina com piperina pode influenciar a elevação aguda de citocinas induzidas pelo exercício: estudo cruzado duplo-cegoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.mdpi.com/2079-7737/11/4/573Stéfani Miranda-CastroDanielle da Glória de SouzaSiomara Aparecida da SilvaKelerson Mauro de Castro PintoGuilherme de Paula CostaAna Filipa SilvaFilipe Manuel ClementeWilliam Valadares Campos PereiraAlbená Nunes-silvaFelipe J. AidarSamara Silva de MouraLucas Marcucci-BarbosaLázaro Fernandes LoboFrancisco de Assis Dias Martins-JúniorRoberta da Silva FilhaPedro Alves Soares Vaz de CastroAna Cristina Simões e Silvaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60277/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALThe curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines_ double-blind crossover study.pdfThe curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines_ double-blind crossover study.pdfapplication/pdf386132https://repositorio.ufmg.br/bitstream/1843/60277/2/The%20curcumin%20supplementation%20with%20piperine%20can%20influence%20the%20acute%20elevation%20of%20exercise-Induced%20cytokines_%20double-blind%20crossover%20study.pdf68b205a99a21861e8c4a904155c17cc2MD521843/602772023-10-30 18:01:12.57oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-10-30T21:01:12Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
The curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines: double-blind crossover study |
dc.title.alternative.pt_BR.fl_str_mv |
A suplementação de curcumina com piperina pode influenciar a elevação aguda de citocinas induzidas pelo exercício: estudo cruzado duplo-cego |
title |
The curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines: double-blind crossover study |
spellingShingle |
The curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines: double-blind crossover study Stéfani Miranda-Castro Curcumin Inflammation Running Dietary supplements Curcumina Inflamação Corrida Suplementos nutricionais |
title_short |
The curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines: double-blind crossover study |
title_full |
The curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines: double-blind crossover study |
title_fullStr |
The curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines: double-blind crossover study |
title_full_unstemmed |
The curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines: double-blind crossover study |
title_sort |
The curcumin supplementation with piperine can influence the acute elevation of exercise-Induced cytokines: double-blind crossover study |
author |
Stéfani Miranda-Castro |
author_facet |
Stéfani Miranda-Castro Danielle da Glória de Souza Siomara Aparecida da Silva Kelerson Mauro de Castro Pinto Guilherme de Paula Costa Ana Filipa Silva Filipe Manuel Clemente William Valadares Campos Pereira Albená Nunes-silva Felipe J. Aidar Samara Silva de Moura Lucas Marcucci-Barbosa Lázaro Fernandes Lobo Francisco de Assis Dias Martins-Júnior Roberta da Silva Filha Pedro Alves Soares Vaz de Castro Ana Cristina Simões e Silva |
author_role |
author |
author2 |
Danielle da Glória de Souza Siomara Aparecida da Silva Kelerson Mauro de Castro Pinto Guilherme de Paula Costa Ana Filipa Silva Filipe Manuel Clemente William Valadares Campos Pereira Albená Nunes-silva Felipe J. Aidar Samara Silva de Moura Lucas Marcucci-Barbosa Lázaro Fernandes Lobo Francisco de Assis Dias Martins-Júnior Roberta da Silva Filha Pedro Alves Soares Vaz de Castro Ana Cristina Simões e Silva |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Stéfani Miranda-Castro Danielle da Glória de Souza Siomara Aparecida da Silva Kelerson Mauro de Castro Pinto Guilherme de Paula Costa Ana Filipa Silva Filipe Manuel Clemente William Valadares Campos Pereira Albená Nunes-silva Felipe J. Aidar Samara Silva de Moura Lucas Marcucci-Barbosa Lázaro Fernandes Lobo Francisco de Assis Dias Martins-Júnior Roberta da Silva Filha Pedro Alves Soares Vaz de Castro Ana Cristina Simões e Silva |
dc.subject.por.fl_str_mv |
Curcumin Inflammation Running Dietary supplements |
topic |
Curcumin Inflammation Running Dietary supplements Curcumina Inflamação Corrida Suplementos nutricionais |
dc.subject.other.pt_BR.fl_str_mv |
Curcumina Inflamação Corrida Suplementos nutricionais |
description |
Background: to evaluate the effects of one week of supplementation with curcumin combined with piperine on physical performance, immune system cell counts, muscle damage, and plasma levels of inflammatory markers after a treadmill running training session. Methods: This study is a double-blind, crossover-balanced clinical trial with a three-week intervention. Sixteen male runners with a mean age of 36 ± 9 years and VO2 max of 60.6 ± 9.03 mL.kg −1 min −1 were recruited and randomly divided into 2 groups: the first group (CPG) was supplemented daily for 7 days with 500 mg of curcumin + 20 mg piperine, and the second group (PG) was supplemented with 540 mg of cellulose. After the 7th day of supplementation, the volunteers participated in the experimental running protocol, where blood samples were collected before, after, and one hour after exercise for analysis of the number of leukocytes, creatine kinase, and cytokine concentration (IL-2, TNF-α, IFN, IL-6, and IL-10) using flow cytometry. This process was repeated, reversing the supplementation offered to the groups. Results: curcumin and piperine supplementation could not change the physical performance, immune cell counts, and muscle damage; however, the aerobic fatiguing exercise protocol inhibited the elevation of the plasmatic levels of some cytokines. The running exercise protocol could elevate the circulating levels of IL-2 (from 49.7 to 59.3 pg/mL), TNF-α (from 48.5 to 51.5 pg/mL), INF (from 128.8 to 165.0 pg/mL), IL-6 (from 63.1 to 77.3 pg/mL), and IL-10 (from 48.9 to 59.6 pg/mL) 1 h after the end of the running protocol. However, the curcumin and piperine supplementation could inhibit this elevation. Conclusions: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-α, INF, IL-6, and IL-10 1 h after the end of exercise. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-10-30T21:01:12Z |
dc.date.available.fl_str_mv |
2023-10-30T21:01:12Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/60277 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3390/biology11040573 |
dc.identifier.issn.pt_BR.fl_str_mv |
2079-7737 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0001-7590-9129 https://orcid.org/0000-0003-3817-3858 https://orcid.org/0000-0002-1772-1272 https://orcid.org/0000-0001-9813-2842 https://orcid.org/0000-0001-7378-4529 https://orcid.org/0000-0003-2485-5137 https://orcid.org/0000-0003-3914-0062 https://orcid.org/0000-0002-4243-0266 https://orcid.org/0000-0002-1183-7610 https://orcid.org/0000-0001-9222-3882 |
url |
https://doi.org/10.3390/biology11040573 http://hdl.handle.net/1843/60277 https://orcid.org/0000-0001-7590-9129 https://orcid.org/0000-0003-3817-3858 https://orcid.org/0000-0002-1772-1272 https://orcid.org/0000-0001-9813-2842 https://orcid.org/0000-0001-7378-4529 https://orcid.org/0000-0003-2485-5137 https://orcid.org/0000-0003-3914-0062 https://orcid.org/0000-0002-4243-0266 https://orcid.org/0000-0002-1183-7610 https://orcid.org/0000-0001-9222-3882 |
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2079-7737 |
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por |
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Biology |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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MED - DEPARTAMENTO DE PEDIATRIA |
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Universidade Federal de Minas Gerais |
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