Ovarian transposition strategy in patients with cervical cancer who undergo pelvic radiation: proposal of ovarian placement based on virtual simulations

Detalhes bibliográficos
Autor(a) principal: Gabriel Oliveira Bernardes Gil
Data de Publicação: 2021
Outros Autores: Agnaldo Lopes Silva-Filho, Cassiano Asano, Maria Luísa Braga Vieira Gil, Warne Andrade, Eduardo Batista Cândido, Marcos Regalin, Izabella Nobre Queiroz, Darly Gomes Soares Delfino, Farley Soares Cantídio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/56138
Resumo: Objective: To establish a proposal for the location for ovarian transposition, considering different irradiation techniques and time to ovarian failure. Methods: Patients with cervical cancer in childbearing age submitted to adjuvant radiotherapy were selected.Delineation of simulated positions of the ovaries and pelvic radiation planning was done in CT, with three techniques: 3D conformal radiotherapy, intensity-modulated radiotherapy, and volumetric modulated arc radiotherapy. In order to correlate the ovaries maximal doses with the time to ovarian failure, the authors have used the one adaptation of Wallace model that predicts oocytes survival rates after radiation exposure. Results: Thirteen patients who were being treated between 2008 and 2017 were studied. When the ovaries were positioned 10 cm cranially from the sacral promontory, the pelvic radiation entails a decrease of 20% in the time to ovarian failure compared with that expected for a female at the same age without irradiation exposition. The placement of the ovaries <5 cm cranially from the sacral promontory results in a decrease >90%. There was no difference in time to ovarian failure between the radiation treatment techniques tested: 3D conformal radiotherapy, intensity-modulated radiotherapy, and volumetric modulated arc radiotherapy (p=0.197). Conclusions: The present study, based on virtual simulations, is the first to use the sacral promontory as a reference for a proposal of ovarian location with transposition. The authors have correlated the position of the ovaries and percentage of decrease in time to ovarian failure. These findings can potentially improve the management and counselling of patients with cervical cancer in childbearing age and deserve clinical validation.
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spelling Ovarian transposition strategy in patients with cervical cancer who undergo pelvic radiation: proposal of ovarian placement based on virtual simulationsCervical cancerRadiotherapyNeoplasias do Colo do ÚteroRadioterapiaObjective: To establish a proposal for the location for ovarian transposition, considering different irradiation techniques and time to ovarian failure. Methods: Patients with cervical cancer in childbearing age submitted to adjuvant radiotherapy were selected.Delineation of simulated positions of the ovaries and pelvic radiation planning was done in CT, with three techniques: 3D conformal radiotherapy, intensity-modulated radiotherapy, and volumetric modulated arc radiotherapy. In order to correlate the ovaries maximal doses with the time to ovarian failure, the authors have used the one adaptation of Wallace model that predicts oocytes survival rates after radiation exposure. Results: Thirteen patients who were being treated between 2008 and 2017 were studied. When the ovaries were positioned 10 cm cranially from the sacral promontory, the pelvic radiation entails a decrease of 20% in the time to ovarian failure compared with that expected for a female at the same age without irradiation exposition. The placement of the ovaries <5 cm cranially from the sacral promontory results in a decrease >90%. There was no difference in time to ovarian failure between the radiation treatment techniques tested: 3D conformal radiotherapy, intensity-modulated radiotherapy, and volumetric modulated arc radiotherapy (p=0.197). Conclusions: The present study, based on virtual simulations, is the first to use the sacral promontory as a reference for a proposal of ovarian location with transposition. The authors have correlated the position of the ovaries and percentage of decrease in time to ovarian failure. These findings can potentially improve the management and counselling of patients with cervical cancer in childbearing age and deserve clinical validation.Universidade Federal de Minas GeraisBrasilMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIAUFMG2023-07-12T19:41:32Z2023-07-12T19:41:32Z2021-07-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf10.33590/emjinnov/20-0017025138634http://hdl.handle.net/1843/56138engEMJ InnovationsGabriel Oliveira Bernardes GilAgnaldo Lopes Silva-FilhoCassiano AsanoMaria Luísa Braga Vieira GilWarne AndradeEduardo Batista CândidoMarcos RegalinIzabella Nobre QueirozDarly Gomes Soares DelfinoFarley Soares Cantídioinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2023-07-12T21:20:19Zoai:repositorio.ufmg.br:1843/56138Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2023-07-12T21:20:19Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Ovarian transposition strategy in patients with cervical cancer who undergo pelvic radiation: proposal of ovarian placement based on virtual simulations
title Ovarian transposition strategy in patients with cervical cancer who undergo pelvic radiation: proposal of ovarian placement based on virtual simulations
spellingShingle Ovarian transposition strategy in patients with cervical cancer who undergo pelvic radiation: proposal of ovarian placement based on virtual simulations
Gabriel Oliveira Bernardes Gil
Cervical cancer
Radiotherapy
Neoplasias do Colo do Útero
Radioterapia
title_short Ovarian transposition strategy in patients with cervical cancer who undergo pelvic radiation: proposal of ovarian placement based on virtual simulations
title_full Ovarian transposition strategy in patients with cervical cancer who undergo pelvic radiation: proposal of ovarian placement based on virtual simulations
title_fullStr Ovarian transposition strategy in patients with cervical cancer who undergo pelvic radiation: proposal of ovarian placement based on virtual simulations
title_full_unstemmed Ovarian transposition strategy in patients with cervical cancer who undergo pelvic radiation: proposal of ovarian placement based on virtual simulations
title_sort Ovarian transposition strategy in patients with cervical cancer who undergo pelvic radiation: proposal of ovarian placement based on virtual simulations
author Gabriel Oliveira Bernardes Gil
author_facet Gabriel Oliveira Bernardes Gil
Agnaldo Lopes Silva-Filho
Cassiano Asano
Maria Luísa Braga Vieira Gil
Warne Andrade
Eduardo Batista Cândido
Marcos Regalin
Izabella Nobre Queiroz
Darly Gomes Soares Delfino
Farley Soares Cantídio
author_role author
author2 Agnaldo Lopes Silva-Filho
Cassiano Asano
Maria Luísa Braga Vieira Gil
Warne Andrade
Eduardo Batista Cândido
Marcos Regalin
Izabella Nobre Queiroz
Darly Gomes Soares Delfino
Farley Soares Cantídio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gabriel Oliveira Bernardes Gil
Agnaldo Lopes Silva-Filho
Cassiano Asano
Maria Luísa Braga Vieira Gil
Warne Andrade
Eduardo Batista Cândido
Marcos Regalin
Izabella Nobre Queiroz
Darly Gomes Soares Delfino
Farley Soares Cantídio
dc.subject.por.fl_str_mv Cervical cancer
Radiotherapy
Neoplasias do Colo do Útero
Radioterapia
topic Cervical cancer
Radiotherapy
Neoplasias do Colo do Útero
Radioterapia
description Objective: To establish a proposal for the location for ovarian transposition, considering different irradiation techniques and time to ovarian failure. Methods: Patients with cervical cancer in childbearing age submitted to adjuvant radiotherapy were selected.Delineation of simulated positions of the ovaries and pelvic radiation planning was done in CT, with three techniques: 3D conformal radiotherapy, intensity-modulated radiotherapy, and volumetric modulated arc radiotherapy. In order to correlate the ovaries maximal doses with the time to ovarian failure, the authors have used the one adaptation of Wallace model that predicts oocytes survival rates after radiation exposure. Results: Thirteen patients who were being treated between 2008 and 2017 were studied. When the ovaries were positioned 10 cm cranially from the sacral promontory, the pelvic radiation entails a decrease of 20% in the time to ovarian failure compared with that expected for a female at the same age without irradiation exposition. The placement of the ovaries <5 cm cranially from the sacral promontory results in a decrease >90%. There was no difference in time to ovarian failure between the radiation treatment techniques tested: 3D conformal radiotherapy, intensity-modulated radiotherapy, and volumetric modulated arc radiotherapy (p=0.197). Conclusions: The present study, based on virtual simulations, is the first to use the sacral promontory as a reference for a proposal of ovarian location with transposition. The authors have correlated the position of the ovaries and percentage of decrease in time to ovarian failure. These findings can potentially improve the management and counselling of patients with cervical cancer in childbearing age and deserve clinical validation.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-16
2023-07-12T19:41:32Z
2023-07-12T19:41:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv 10.33590/emjinnov/20-00170
25138634
http://hdl.handle.net/1843/56138
identifier_str_mv 10.33590/emjinnov/20-00170
25138634
url http://hdl.handle.net/1843/56138
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv EMJ Innovations
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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