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2023-11-06T21:41:57Z2023-11-06T21:41:57Z202066566667210.1590/1806-9282.66.5.66601044230http://hdl.handle.net/1843/60542Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease characterized by multisystem involvement including low bone mineral density (BMD).OBJECTIVE: To assess the bone phenotype of individuals with NF1 and verify its associationwith nutrient intake.METHODS: Twenty-six adults with NF1 underwent bone phenotype assessments using dual-energy X-ray absorptiometry (DXA) andfood intake evaluations. They were compared to 26 unaffected matched control patients. Weight, height, and waist circumference(WC) were measured. DXA provided total body, spine, and hip BMDs and bone mineral content (BMC) for all patients. Food intake was evaluated for energy, macro- and micro-nutrients.RESULTS: Height (1.68 ± 0.1; 1.61 ± 0.1 cm; P = 0.003) and BMC (2.3 ± 0.4; 2.0 ± 0.5 kg; P = 0.046) were lower in the NF1 group. Individuals with NF1 also presented lower total body and spine BMDs (g/cm2) (1.1 ± 0.1, 1.0 ± 0.1, P = 0.036; 1.0 ± 0.1, 0.9 ± 0.1; P = 0.015,respectively). The frequency of total body bone mass below the expected level for patients’ ages was higher in the NF1 group (7.7%;34.6%, P = 0.016). There were no differences in energy consumption. No correlations between BMC and BMD with nutrient intake were observed in the NF1 group.CONCLUSIONS: The NF1 group presented lower BMCs and BMDs. Although a lower consumption of calcium, iron, and vitamin A, and a higher intake of sodium and omega-6 were observed, there was no relationship between bone phenotype and nutrient intake.engUniversidade Federal de Minas GeraisUFMGBrasilENF - DEPARTAMENTO DE ENFERMAGEM APLICADAENF - DEPARTAMENTO DE NUTRIÇÃOMED - DEPARTAMENTO DE APARELHO LOCOMOTORMED - DEPARTAMENTO DE CLÍNICA MÉDICARevista da Associação Médica BrasileiraNeurofibromatosis 1EatingNutritional RequirementsNutrientsneurofibromatosis type 1BoneNutrientFood intakeNutritionReduced bone mineral content and density in neurofibromatosis type 1 and its association with nutrient intakeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/1806-9282.66.5.666Márcio Leandro Ribeiro de SouzaAnn Kristine JansenLuiz Oswaldo c RodriguesDarlene VilelaAdriana KakehasiAline Stangherlin MartinsJuliana Ferreira de SouzaNilton Alves Resendeapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60542/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALReduced bone mineral content and density in neurofibromatosis type 1 and its association with nutrient intake pdfa.pdfReduced bone mineral content and density in neurofibromatosis type 1 and its association with nutrient intake pdfa.pdfapplication/pdf237991https://repositorio.ufmg.br/bitstream/1843/60542/2/Reduced%20bone%20mineral%20content%20and%20density%20in%20neurofibromatosis%20type%201%20and%20its%20association%20with%20nutrient%20intake%20pdfa.pdf673fc9ea5bbc21e666f5493e6069e1b8MD521843/605422023-11-06 20:51:53.359oai:repositorio.ufmg.br:1843/60542Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-11-06T23:51:53Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
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