Rapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosis

• Autor(a) principal: Marcus Vinicius Canário Viana
• Data de Publicação: 2018
• Outros Autores: Arne Sahm, Aristóteles Góes Neto, Henrique Cesar Pereira Figueiredo, Alice Rebecca Wattam, Vasco Ariston de Carvalho Azevedo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://dx.doi.org/10.1371/journal.pone.0207304; http://hdl.handle.net/1843/55173; http://orcid.org/0000-0002-7017-6437; https://orcid.org/0000-0002-7330-1790; https://orcid.org/0000-0002-7692-6243; https://orcid.org/0000-0002-1022-6842; https://orcid.org/0000-0001-6018-6490
• topic: Corynebacterium pseudotuberculosis; Host switching; Gene loss; Corynebacterium pseudotuberculosis; Adaptação ao hospedeiro; Técnicas de inativação de genes

Phylogenomics and genome scale positive selection analyses were performed on 29 Corynebacterium pseudotuberculosis genomes that were isolated from different hosts, including representatives of the Ovis and Equi biovars. A total of 27 genes were identified as undergoing adaptive changes. An analysis of the clades within this species and these biovars, the genes specific to each branch, and the genes responding to selective pressure show clear differences, indicating that adaptation and specialization is occurring in different clades. These changes are often correlated with the isolation host but could indicate responses to some undetermined factor in the respective niches. The fact that some of these more-rapidly evolving genes have homology to known virulence factors, antimicrobial resistance genes and drug targets shows that this type of analysis could be used to identify novel targets, and that these could be used as a way to control this pathogen.