Smoking and its association with cryptorchidism in down syndrome

• Autor(a) principal: Adrianne Maria Berno Rezende Duarte
• Data de Publicação: 2017
• Outros Autores: José de Bessa, Flavia Cristina de Carvalho Mrad, Sandra Helena Cerrato Tibiriça, Maira Camargo, Augusto Alves Pinho Vieira, Frederico Cantarino Cordeiro Araujo, André Avarese de Figueiredo, Jose Murillo Bastos Netto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://dx.doi.org/10.1590/1806-9282.63.08.693; http://hdl.handle.net/1843/59675
• topic: Smoking; Down syndrome; Cryptorchidism; Urologic diseases; Smoking; Down syndrome; Cryptorchidism; Urologic diseases

Introduction: Cryptorchidism is a common and prevalent condition in patients with Down syndrome. Environmental factors, such as smoking, can be associated with malformations during fetal development. The study of the prevalence of cryptorchidism and its association with parental tobacco use in Down syndrome can contribute to alert health care professionals, patients and family members regarding the prevention of the harms caused by cryptorchidism and its possible predisposing factors. Objective: To evaluate the prevalence of cryptorchidism in Down syndrome and its association with maternal and paternal smoking.Method: Forty (40) patients of a public clinic specialized in Down syndrome were evaluated, using a semi-structured questionnaire for evaluation of antecedents and sociodemographic characteristics, as well as physical and complementary examinations.Results: Cryptorchidism was observed in 27.5% of the patients (95CI 15.98-42.96). Of these, 55% (5/9) were the children of mothers who smoked during pregnancy, and 19.35% (6/31) were the children of mothers who did not smoke during pregnancy (OR = 5.26 [95CI 1.06-25.41]; p=0.032). Similarly, paternal smoking was also observed in greater frequency among the parents of cryptorchid patients compared with subjects with descended testis, 63.36% (7/11) and 31.03% (9/29), respectively (OR = 3.89 [95CI 0.91-16.73]; p=0.060).Conclusion: The prevalence of cryptorchidism is high in patients with Down syndrome. We can show a strong association between smoking parents and the occurrence of cryptorchidism, especially when it comes to maternal smoking.