Vestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal Myeloradiculopathy
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1371/journal.pntd.0004672 http://hdl.handle.net/1843/40290 |
Resumo: | Background: Schistosomal myeloradiculopathy (SMR), the most severe and disabling ectopic form of Schistosoma mansoni infection, is caused by embolized ova eliciting local inflammation in the spinal cord and nerve roots. The treatment involves the use of praziquantel and long-term corticotherapy. The assessment of therapeutic response relies on neurological examination. Supplementary electrophysiological exams may improve prediction and monitoring of functional outcome. Vestibular evoked myogenic potential (VEMP) triggered by galvanic vestibular stimulation (GVS) is a simple, safe, low-cost and noninvasive electrophysiological technique that has been used to test the vestibulospinal tract in motor myelopathies. This paper reports the results of VEMP with GVS in patients with SMR. Methods: A cross-sectional comparative study enrolled 22 patients with definite SMR and 22 healthy controls that were submitted to clinical, neurological examination and GVS. Galvanic stimulus was applied in the mastoid bones in a transcranial configuration for testing VEMP, which was recorded by electromyography (EMG) in the gastrocnemii muscles. The VEMP variables of interest were blindly measured by two independent examiners. They were the short-latency (SL) and the medium-latency (ML) components of the biphasic EMG wave. Results: VEMP showed the components SL (p = 0.001) and ML (p<0.001) delayed in SMR compared to controls. The delay of SL (p = 0.010) and of ML (p = 0.020) was associated with gait dysfunction. Conclusion: VEMP triggered by GVS identified alterations in patients with SMR and provided additional functional information that justifies its use as a supplementary test in motor myelopathies. |
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2022-03-21T20:40:11Z2022-03-21T20:40:11Z2016104https://doi.org/10.1371/journal.pntd.000467219352735http://hdl.handle.net/1843/40290Background: Schistosomal myeloradiculopathy (SMR), the most severe and disabling ectopic form of Schistosoma mansoni infection, is caused by embolized ova eliciting local inflammation in the spinal cord and nerve roots. The treatment involves the use of praziquantel and long-term corticotherapy. The assessment of therapeutic response relies on neurological examination. Supplementary electrophysiological exams may improve prediction and monitoring of functional outcome. Vestibular evoked myogenic potential (VEMP) triggered by galvanic vestibular stimulation (GVS) is a simple, safe, low-cost and noninvasive electrophysiological technique that has been used to test the vestibulospinal tract in motor myelopathies. This paper reports the results of VEMP with GVS in patients with SMR. Methods: A cross-sectional comparative study enrolled 22 patients with definite SMR and 22 healthy controls that were submitted to clinical, neurological examination and GVS. Galvanic stimulus was applied in the mastoid bones in a transcranial configuration for testing VEMP, which was recorded by electromyography (EMG) in the gastrocnemii muscles. The VEMP variables of interest were blindly measured by two independent examiners. They were the short-latency (SL) and the medium-latency (ML) components of the biphasic EMG wave. Results: VEMP showed the components SL (p = 0.001) and ML (p<0.001) delayed in SMR compared to controls. The delay of SL (p = 0.010) and of ML (p = 0.020) was associated with gait dysfunction. Conclusion: VEMP triggered by GVS identified alterations in patients with SMR and provided additional functional information that justifies its use as a supplementary test in motor myelopathies.Introdução: A mielorradiculopatia esquistossomótica (SMR), a forma ectópica mais grave e incapacitante da infecção por Schistosoma mansoni, é causada por óvulos embolizados que provocam inflamação local na medula espinhal e raízes nervosas. O tratamento envolve o uso de praziquantel e corticoterapia de longa duração. A avaliação da resposta terapêutica baseia-se no exame neurológico. Exames eletrofisiológicos complementares podem melhorar a previsão e o monitoramento do resultado funcional. O potencial evocado miogênico vestibular (VEMP) desencadeado pela estimulação vestibular galvânica (EVG) é uma técnica eletrofisiológica simples, segura, de baixo custo e não invasiva que vem sendo utilizada para testar o trato vestíbulo-espinhal nas mielopatias motoras. Este trabalho relata os resultados do VEMP com GVS em pacientes com SMR. Métodos: Um estudo transversal comparativo envolveu 22 pacientes com SMR definida e 22 controles saudáveis que foram submetidos a exame clínico, neurológico e GVS. Foi aplicado estímulo galvânico nos ossos mastóides em configuração transcraniana para teste do VEMP, que foi registrado por eletromiografia (EMG) nos músculos gastrocnêmios. As variáveis de interesse do VEMP foram mensuradas às cegas por dois examinadores independentes. Eles eram os componentes de latência curta (SL) e de latência média (ML) da onda EMG bifásica. Resultados: O VEMP apresentou os componentes SL (p = 0,001) e ML (p<0,001) atrasados no SMR em relação aos controles. O atraso do SL (p = 0,010) e do ML (p = 0,020) foi associado à disfunção da marcha. Conclusão: O VEMP desencadeado pela GVS identificou alterações em pacientes com SMR e forneceu informações funcionais adicionais que justificam seu uso como teste complementar nas mielopatias motoras.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE CLÍNICA MÉDICAMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIAPlos neglected tropical diseasesPotencial Miogênico Evocado VestibularMielorradiculopatiaEsquistossomose MansônicaVestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal MyeloradiculopathyPotencial Miogênico Evocado Vestibular (VEMP) Acionado por Vestibular Galvânico Estimulação (GVS): uma ferramenta promissora para avaliar Função da Medula Espinhal em Esquistossomose Mielorradiculopatiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004672Júlia Fonseca de MoraiscaporaliDenise Utsch GonçalvesLudimila LabancaLeonardo Dornas de OliveiraGuilherme Vaz de Melo TrindadeThiago de Almeida PereiraPedro Henrique Diniz CunhaMarina Santos Falci MourãoJose Roberto Lambertucciapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Vestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal Myeloradiculopathy |
dc.title.alternative.pt_BR.fl_str_mv |
Potencial Miogênico Evocado Vestibular (VEMP) Acionado por Vestibular Galvânico Estimulação (GVS): uma ferramenta promissora para avaliar Função da Medula Espinhal em Esquistossomose Mielorradiculopatia |
title |
Vestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal Myeloradiculopathy |
spellingShingle |
Vestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal Myeloradiculopathy Júlia Fonseca de Moraiscaporali Potencial Miogênico Evocado Vestibular Mielorradiculopatia Esquistossomose Mansônica |
title_short |
Vestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal Myeloradiculopathy |
title_full |
Vestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal Myeloradiculopathy |
title_fullStr |
Vestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal Myeloradiculopathy |
title_full_unstemmed |
Vestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal Myeloradiculopathy |
title_sort |
Vestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal Myeloradiculopathy |
author |
Júlia Fonseca de Moraiscaporali |
author_facet |
Júlia Fonseca de Moraiscaporali Denise Utsch Gonçalves Ludimila Labanca Leonardo Dornas de Oliveira Guilherme Vaz de Melo Trindade Thiago de Almeida Pereira Pedro Henrique Diniz Cunha Marina Santos Falci Mourão Jose Roberto Lambertucci |
author_role |
author |
author2 |
Denise Utsch Gonçalves Ludimila Labanca Leonardo Dornas de Oliveira Guilherme Vaz de Melo Trindade Thiago de Almeida Pereira Pedro Henrique Diniz Cunha Marina Santos Falci Mourão Jose Roberto Lambertucci |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Júlia Fonseca de Moraiscaporali Denise Utsch Gonçalves Ludimila Labanca Leonardo Dornas de Oliveira Guilherme Vaz de Melo Trindade Thiago de Almeida Pereira Pedro Henrique Diniz Cunha Marina Santos Falci Mourão Jose Roberto Lambertucci |
dc.subject.other.pt_BR.fl_str_mv |
Potencial Miogênico Evocado Vestibular Mielorradiculopatia Esquistossomose Mansônica |
topic |
Potencial Miogênico Evocado Vestibular Mielorradiculopatia Esquistossomose Mansônica |
description |
Background: Schistosomal myeloradiculopathy (SMR), the most severe and disabling ectopic form of Schistosoma mansoni infection, is caused by embolized ova eliciting local inflammation in the spinal cord and nerve roots. The treatment involves the use of praziquantel and long-term corticotherapy. The assessment of therapeutic response relies on neurological examination. Supplementary electrophysiological exams may improve prediction and monitoring of functional outcome. Vestibular evoked myogenic potential (VEMP) triggered by galvanic vestibular stimulation (GVS) is a simple, safe, low-cost and noninvasive electrophysiological technique that has been used to test the vestibulospinal tract in motor myelopathies. This paper reports the results of VEMP with GVS in patients with SMR. Methods: A cross-sectional comparative study enrolled 22 patients with definite SMR and 22 healthy controls that were submitted to clinical, neurological examination and GVS. Galvanic stimulus was applied in the mastoid bones in a transcranial configuration for testing VEMP, which was recorded by electromyography (EMG) in the gastrocnemii muscles. The VEMP variables of interest were blindly measured by two independent examiners. They were the short-latency (SL) and the medium-latency (ML) components of the biphasic EMG wave. Results: VEMP showed the components SL (p = 0.001) and ML (p<0.001) delayed in SMR compared to controls. The delay of SL (p = 0.010) and of ML (p = 0.020) was associated with gait dysfunction. Conclusion: VEMP triggered by GVS identified alterations in patients with SMR and provided additional functional information that justifies its use as a supplementary test in motor myelopathies. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2022-03-21T20:40:11Z |
dc.date.available.fl_str_mv |
2022-03-21T20:40:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/40290 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1371/journal.pntd.0004672 |
dc.identifier.issn.pt_BR.fl_str_mv |
19352735 |
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https://doi.org/10.1371/journal.pntd.0004672 http://hdl.handle.net/1843/40290 |
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19352735 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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Plos neglected tropical diseases |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA |
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Universidade Federal de Minas Gerais |
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