Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.2147/IJN.S109966 http://hdl.handle.net/1843/51493 https://orcid.org/0000-0003-1505-7950 https://orcid.org/0000-0002-3179-6537 https://orcid.org/0000-0003-2474-5536 https://orcid.org/0000-0002-8703-4283 https://orcid.org/0000-0002-5203-0944 https://orcid.org/0000-0002-3656-4882 https://orcid.org/0000-0002-7687-4746 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2023-04-03T16:42:53Z2023-04-03T16:42:53Z20161137373751https://doi.org/10.2147/IJN.S1099661178-2013http://hdl.handle.net/1843/51493https://orcid.org/0000-0003-1505-7950https://orcid.org/0000-0002-3179-6537https://orcid.org/0000-0003-2474-5536https://orcid.org/0000-0002-8703-4283https://orcid.org/0000-0002-5203-0944https://orcid.org/0000-0002-3656-4882https://orcid.org/0000-0002-7687-4746CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorDespite recent advances in cancer therapy, the treatment of bone tumors remains a major challenge. A possible underlying hypothesis, limitation, and unmet need may be the inability of therapeutics to penetrate into dense bone mineral, which can lead to poor efficacy and high toxicity, due to drug uptake in healthy organs. The development of nanostructured formulations with high affinity for bone could be an interesting approach to overcome these challenges.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSICX - DEPARTAMENTO DE FÍSICAInternational Journal of NanomedicineCâncerLipossomosOssosHydroxyapatite-targeted formulationsBisphosphonatesPH-responsive nanostructuresBone-tumor treatmentDevelopment of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://pubmed.ncbi.nlm.nih.gov/27563241/Diêgo dos Santos FerreiraPeter CaravanLucas Antônio Miranda FerreiraRicardo José AlvesMônica Cristina de OliveiraSamilla Dornellas FariaSávia Caldeira de Araújo LopesCláudia Salviano TeixeiraÂngelo Malachias de SouzaRogério Magalhães PaniagoJosé Dias de Souza FilhoBruno Luís de Jesus Pinto OliveiraAlexander Sávio Ramos Guimarãesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/51493/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALDevelopment of a bone-targeted ph-sensitive liposomal formulation containing doxorubicin.pdfDevelopment of a bone-targeted ph-sensitive liposomal formulation containing doxorubicin.pdfapplication/pdf1029514https://repositorio.ufmg.br/bitstream/1843/51493/2/Development%20of%20a%20bone-targeted%20ph-sensitive%20liposomal%20formulation%20containing%20doxorubicin.pdfe67730a85da436baa5c9f1d1f540cf17MD521843/514932023-04-03 16:29:20.267oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-04-03T19:29:20Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis |
| title |
Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis |
| spellingShingle |
Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis Diêgo dos Santos Ferreira Hydroxyapatite-targeted formulations Bisphosphonates PH-responsive nanostructures Bone-tumor treatment Câncer Lipossomos Ossos |
| title_short |
Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis |
| title_full |
Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis |
| title_fullStr |
Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis |
| title_full_unstemmed |
Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis |
| title_sort |
Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis |
| author |
Diêgo dos Santos Ferreira |
| author_facet |
Diêgo dos Santos Ferreira Peter Caravan Lucas Antônio Miranda Ferreira Ricardo José Alves Mônica Cristina de Oliveira Samilla Dornellas Faria Sávia Caldeira de Araújo Lopes Cláudia Salviano Teixeira Ângelo Malachias de Souza Rogério Magalhães Paniago José Dias de Souza Filho Bruno Luís de Jesus Pinto Oliveira Alexander Sávio Ramos Guimarães |
| author_role |
author |
| author2 |
Peter Caravan Lucas Antônio Miranda Ferreira Ricardo José Alves Mônica Cristina de Oliveira Samilla Dornellas Faria Sávia Caldeira de Araújo Lopes Cláudia Salviano Teixeira Ângelo Malachias de Souza Rogério Magalhães Paniago José Dias de Souza Filho Bruno Luís de Jesus Pinto Oliveira Alexander Sávio Ramos Guimarães |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Diêgo dos Santos Ferreira Peter Caravan Lucas Antônio Miranda Ferreira Ricardo José Alves Mônica Cristina de Oliveira Samilla Dornellas Faria Sávia Caldeira de Araújo Lopes Cláudia Salviano Teixeira Ângelo Malachias de Souza Rogério Magalhães Paniago José Dias de Souza Filho Bruno Luís de Jesus Pinto Oliveira Alexander Sávio Ramos Guimarães |
| dc.subject.por.fl_str_mv |
Hydroxyapatite-targeted formulations Bisphosphonates PH-responsive nanostructures Bone-tumor treatment |
| topic |
Hydroxyapatite-targeted formulations Bisphosphonates PH-responsive nanostructures Bone-tumor treatment Câncer Lipossomos Ossos |
| dc.subject.other.pt_BR.fl_str_mv |
Câncer Lipossomos Ossos |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2016 |
| dc.date.issued.fl_str_mv |
2016 |
| dc.date.accessioned.fl_str_mv |
2023-04-03T16:42:53Z |
| dc.date.available.fl_str_mv |
2023-04-03T16:42:53Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/51493 |
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https://doi.org/10.2147/IJN.S109966 |
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1178-2013 |
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https://orcid.org/0000-0003-1505-7950 https://orcid.org/0000-0002-3179-6537 https://orcid.org/0000-0003-2474-5536 https://orcid.org/0000-0002-8703-4283 https://orcid.org/0000-0002-5203-0944 https://orcid.org/0000-0002-3656-4882 https://orcid.org/0000-0002-7687-4746 |
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https://doi.org/10.2147/IJN.S109966 http://hdl.handle.net/1843/51493 https://orcid.org/0000-0003-1505-7950 https://orcid.org/0000-0002-3179-6537 https://orcid.org/0000-0003-2474-5536 https://orcid.org/0000-0002-8703-4283 https://orcid.org/0000-0002-5203-0944 https://orcid.org/0000-0002-3656-4882 https://orcid.org/0000-0002-7687-4746 |
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1178-2013 |
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eng |
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eng |
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International Journal of Nanomedicine |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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Brasil |
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FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICX - DEPARTAMENTO DE FÍSICA |
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Universidade Federal de Minas Gerais |
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