The use of metabolomic tool in assessing environmental exposure
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.14302/issn.2690-0904.ijoe-21-3966 http://hdl.handle.net/1843/54488 |
Resumo: | The impact of the environment on the development of non-communicable chronic diseases has gained prominence in recent years. In this context, a new chemical exposure assessment strategy is needed that is capable of revealing multiple exposures, as well as reflecting the cumulative interaction between such environmental contaminants in the biological system. From this perspective, metabolomics emerges as a promising tool in this field of knowledge, since it is able to identify changes in metabolism and/or gene expression resulting from exposure to environmental factors. The aim of this study was to describe important concepts, as well as the steps that permeate the metabolomics analysis, and also to present some relevant works with the application of metabolomics in the assessment of chemical exposure. A literature review showed a significant increase in the use of metabolomics in environmental toxicology in recent years. This increase is mainly due to advances in analytical techniques and the improvement of data processing tools. However, this field of investigation remains little explored, especially with regard to the study of toxicity associated with chronic exposure to low levels of chemical agents. Thus, it is urgent that omic biomarkers can be used as a tool for decision-making, especially with a view to protecting, diagnosing and recovering human health. |
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2023-06-05T12:40:32Z2023-06-05T12:40:32Z2021-10-06131031https://doi.org/10.14302/issn.2690-0904.ijoe-21-39662690-0904http://hdl.handle.net/1843/54488The impact of the environment on the development of non-communicable chronic diseases has gained prominence in recent years. In this context, a new chemical exposure assessment strategy is needed that is capable of revealing multiple exposures, as well as reflecting the cumulative interaction between such environmental contaminants in the biological system. From this perspective, metabolomics emerges as a promising tool in this field of knowledge, since it is able to identify changes in metabolism and/or gene expression resulting from exposure to environmental factors. The aim of this study was to describe important concepts, as well as the steps that permeate the metabolomics analysis, and also to present some relevant works with the application of metabolomics in the assessment of chemical exposure. A literature review showed a significant increase in the use of metabolomics in environmental toxicology in recent years. This increase is mainly due to advances in analytical techniques and the improvement of data processing tools. However, this field of investigation remains little explored, especially with regard to the study of toxicity associated with chronic exposure to low levels of chemical agents. Thus, it is urgent that omic biomarkers can be used as a tool for decision-making, especially with a view to protecting, diagnosing and recovering human health.O impacto do meio ambiente no desenvolvimento de doenças crônicas não transmissíveis ganhou destaque nos últimos anos. Nesse contexto, é necessária uma nova estratégia de avaliação da exposição química que seja capaz de revelar exposições múltiplas, bem como refletir a interação cumulativa entre esses contaminantes ambientais no sistema biológico. Nessa perspectiva, a metabolômica surge como uma ferramenta promissora nessa área do conhecimento, pois é capaz de identificar alterações no metabolismo e/ou na expressão gênica decorrentes da exposição a fatores ambientais. O objetivo deste estudo foi descrever conceitos importantes, bem como as etapas que permeiam a análise metabolômica, e também apresentar alguns trabalhos relevantes com a aplicação da metabolômica na avaliação da exposição a produtos químicos. Uma revisão da literatura mostrou um aumento significativo no uso de metabolômica em toxicologia ambiental nos últimos anos. Esse aumento se deve principalmente ao avanço das técnicas analíticas e ao aprimoramento das ferramentas de processamento de dados. No entanto, esse campo de investigação ainda é pouco explorado, principalmente no que diz respeito ao estudo da toxicidade associada à exposição crônica a baixos níveis de agentes químicos. Assim, é urgente que os biomarcadores ômicos possam ser utilizados como ferramenta para a tomada de decisões, principalmente com vistas à proteção, diagnóstico e recuperação da saúde humana.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASInternational Journal of Occupational and Environmental MedicineMetabolômicaBiomarcadoresExposição ambientalEcotoxicologiaMetabolomicBiomarkersEnvironmental exposureEnvironmental toxicologyThe use of metabolomic tool in assessing environmental exposureinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://openaccesspub.org/ijoe/article/1708#:~:text=Metabolomics%20has%20been%20used%20to,reveal%20disease%20onset%20and%20prognosisMichele Polyana Rocha MendesLeiliane Coelho Andréapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/54488/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALThe use of metabolomic tool in assessing environmentale exposure.pdfThe use of metabolomic tool in assessing environmentale exposure.pdfapplication/pdf742694https://repositorio.ufmg.br/bitstream/1843/54488/2/The%20use%20of%20metabolomic%20tool%20in%20assessing%20environmentale%20exposure.pdff603d4098694a103eeb3a26d42ef5657MD521843/544882023-06-05 16:49:05.324oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-06-05T19:49:05Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
The use of metabolomic tool in assessing environmental exposure |
title |
The use of metabolomic tool in assessing environmental exposure |
spellingShingle |
The use of metabolomic tool in assessing environmental exposure Michele Polyana Rocha Mendes Metabolomic Biomarkers Environmental exposure Environmental toxicology Metabolômica Biomarcadores Exposição ambiental Ecotoxicologia |
title_short |
The use of metabolomic tool in assessing environmental exposure |
title_full |
The use of metabolomic tool in assessing environmental exposure |
title_fullStr |
The use of metabolomic tool in assessing environmental exposure |
title_full_unstemmed |
The use of metabolomic tool in assessing environmental exposure |
title_sort |
The use of metabolomic tool in assessing environmental exposure |
author |
Michele Polyana Rocha Mendes |
author_facet |
Michele Polyana Rocha Mendes Leiliane Coelho André |
author_role |
author |
author2 |
Leiliane Coelho André |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Michele Polyana Rocha Mendes Leiliane Coelho André |
dc.subject.por.fl_str_mv |
Metabolomic Biomarkers Environmental exposure Environmental toxicology |
topic |
Metabolomic Biomarkers Environmental exposure Environmental toxicology Metabolômica Biomarcadores Exposição ambiental Ecotoxicologia |
dc.subject.other.pt_BR.fl_str_mv |
Metabolômica Biomarcadores Exposição ambiental Ecotoxicologia |
description |
The impact of the environment on the development of non-communicable chronic diseases has gained prominence in recent years. In this context, a new chemical exposure assessment strategy is needed that is capable of revealing multiple exposures, as well as reflecting the cumulative interaction between such environmental contaminants in the biological system. From this perspective, metabolomics emerges as a promising tool in this field of knowledge, since it is able to identify changes in metabolism and/or gene expression resulting from exposure to environmental factors. The aim of this study was to describe important concepts, as well as the steps that permeate the metabolomics analysis, and also to present some relevant works with the application of metabolomics in the assessment of chemical exposure. A literature review showed a significant increase in the use of metabolomics in environmental toxicology in recent years. This increase is mainly due to advances in analytical techniques and the improvement of data processing tools. However, this field of investigation remains little explored, especially with regard to the study of toxicity associated with chronic exposure to low levels of chemical agents. Thus, it is urgent that omic biomarkers can be used as a tool for decision-making, especially with a view to protecting, diagnosing and recovering human health. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-10-06 |
dc.date.accessioned.fl_str_mv |
2023-06-05T12:40:32Z |
dc.date.available.fl_str_mv |
2023-06-05T12:40:32Z |
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info:eu-repo/semantics/article |
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http://hdl.handle.net/1843/54488 |
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https://doi.org/10.14302/issn.2690-0904.ijoe-21-3966 |
dc.identifier.issn.pt_BR.fl_str_mv |
2690-0904 |
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https://doi.org/10.14302/issn.2690-0904.ijoe-21-3966 http://hdl.handle.net/1843/54488 |
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2690-0904 |
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eng |
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eng |
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International Journal of Occupational and Environmental Medicine |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS |
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Universidade Federal de Minas Gerais |
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