Preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays

Detalhes bibliográficos
Autor(a) principal: Isabelle Pinto
Data de Publicação: 2020
Outros Autores: Gustavo Henrique Bianco de Souza, Walison Arthuso Vasconcellos, Paula Vieira, Ângela Andrade, Janaína Seibert, Luciano Pinto, Vagner Santos, Rafaela de Sousa, Lucas Sousa, Tatiane Amparo, Viviane dos Santos, Andrea do Nascimento
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.1038/s41598-020-79257-3
http://hdl.handle.net/1843/52485
Resumo: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
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spelling 2023-04-25T20:40:01Z2023-04-25T20:40:01Z2020-12-181010113https://doi.org/10.1038/s41598-020-79257-320452322http://hdl.handle.net/1843/52485CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorPlants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identified by UPLC-QTOF-MS/MS. The release profile of flavonoids and the mechanical properties of the GIC-BPE composite were assessed. The flavonoids were released through a linear mechanism governing the diffusion for the first 48 h, as evidenced by the Mt/M∞ relatively to [Formula: see text], at a diffusion coefficient of 1.406 × 10-6 cm2 s-1. The ATR-FTIR analysis indicated that a chemical bond between the GIC and BPE components may have occurred, but the compressive strength of GIC-BPE does not differ significantly from that of this glass-ionomer. The GIC-BPE sample revealed an ample bacterial activity at non-cytotoxic concentrations for the human fibroblast MRC-5 cells. These results suggest that the prepared composite may represent an alternative agent for endodontic treatment.engUniversidade Federal de Minas GeraisUFMGBrasilFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORAScientific ReportsPharmaceutical preparationsFlavonoidsPreparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assaysinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://pubmed.ncbi.nlm.nih.gov/33339861/Isabelle PintoGustavo Henrique Bianco de SouzaWalison Arthuso VasconcellosPaula VieiraÂngela AndradeJanaína SeibertLuciano PintoVagner SantosRafaela de SousaLucas SousaTatiane AmparoViviane dos SantosAndrea do Nascimentoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALPreparation of glass ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits chemical and biological assays.pdfPreparation of glass ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits chemical and biological assays.pdfapplication/pdf1690517https://repositorio.ufmg.br/bitstream/1843/52485/2/Preparation%20of%20glass%20ionomer%20cement%20containing%20ethanolic%20brazilian%20pepper%20extract%20%28schinus%20terebinthifolius%20raddi%29%20fruits%20chemical%20and%20biological%20assays.pdf1e357678c70316f914866996bdce8456MD52LICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/52485/1/License.txtfa505098d172de0bc8864fc1287ffe22MD511843/524852023-04-25 17:40:02.092oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-04-25T20:40:02Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays
title Preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays
spellingShingle Preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays
Isabelle Pinto
Pharmaceutical preparations
Flavonoids
title_short Preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays
title_full Preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays
title_fullStr Preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays
title_full_unstemmed Preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays
title_sort Preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays
author Isabelle Pinto
author_facet Isabelle Pinto
Gustavo Henrique Bianco de Souza
Walison Arthuso Vasconcellos
Paula Vieira
Ângela Andrade
Janaína Seibert
Luciano Pinto
Vagner Santos
Rafaela de Sousa
Lucas Sousa
Tatiane Amparo
Viviane dos Santos
Andrea do Nascimento
author_role author
author2 Gustavo Henrique Bianco de Souza
Walison Arthuso Vasconcellos
Paula Vieira
Ângela Andrade
Janaína Seibert
Luciano Pinto
Vagner Santos
Rafaela de Sousa
Lucas Sousa
Tatiane Amparo
Viviane dos Santos
Andrea do Nascimento
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Isabelle Pinto
Gustavo Henrique Bianco de Souza
Walison Arthuso Vasconcellos
Paula Vieira
Ângela Andrade
Janaína Seibert
Luciano Pinto
Vagner Santos
Rafaela de Sousa
Lucas Sousa
Tatiane Amparo
Viviane dos Santos
Andrea do Nascimento
dc.subject.other.pt_BR.fl_str_mv Pharmaceutical preparations
Flavonoids
topic Pharmaceutical preparations
Flavonoids
description CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
publishDate 2020
dc.date.issued.fl_str_mv 2020-12-18
dc.date.accessioned.fl_str_mv 2023-04-25T20:40:01Z
dc.date.available.fl_str_mv 2023-04-25T20:40:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/52485
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.1038/s41598-020-79257-3
dc.identifier.issn.pt_BR.fl_str_mv 20452322
url https://doi.org/10.1038/s41598-020-79257-3
http://hdl.handle.net/1843/52485
identifier_str_mv 20452322
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Scientific Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/52485/2/Preparation%20of%20glass%20ionomer%20cement%20containing%20ethanolic%20brazilian%20pepper%20extract%20%28schinus%20terebinthifolius%20raddi%29%20fruits%20chemical%20and%20biological%20assays.pdf
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repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
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