Pulmonary function in former very low birth weight preterm infants in the first year of life
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1016/j.rmed.2018.02.004 http://hdl.handle.net/1843/48304 https://orcid.org/0000-0001-5243-2436 http://orcid.org/0000-0003-2173-4380 https://orcid.org/0000-0001-9845-6097 https://orcid.org/0000-0002-4748-6947 https://orcid.org/0000-0002-3579-0861 http://orcid.org/0000-0002-8407-1556 |
Resumo: | Background: Pulmonary function in former preterm infants may be compromised during childhood. Objectives: To assess pulmonary function in very-low-birth-weight preterm infants at 6–12 months of corrected age and analyze the factors associated with abnormal pulmonary function. Methods: Cross-sectional study with preterm infants at 6–12 months of corrected age with birth weight <1500 g. Children with malformations or affected by neuromuscular and respiratory diseases were excluded. Forced expiratory flows were assessed using the chest compression technique, and volumes were measured by total body plethysmography. Pulmonary function parameters in preterm infants were compared to a control group of same-aged children born at term. Results: We studied 51 preterm and 37 infants born at term. Preterm infants had: gestational age at birth (30.0 ± 2.5 weeks), birth weight (1179 ± 247 g), 27.5% had bronchopulmonary dysplasia, and 45% received mechanical ventilation. Preterm infants had lower median z-scores in comparison to term infants for the following parameters (p < 0.05): FVC (−0.3 vs. 0.7), FEV0.5 (−0.5 vs. 0.9), FEV0.5/FVC (−0.6 vs. −0.5), FEF50 (−0.4 vs. 0.9), FEF75 (−0.3 vs. 0.8), FEF85 (−0.1 vs. 0.6) and FEF25-75 (−0.5 vs. 1.1). No term child had abnormal lung function, compared to 39.2% of preterm infants (p = 0.001). Factors associated with abnormal pulmonary function were lower gestational age at birth, small for gestational age, need for mechanical ventilation and presence of recurrent wheezing. Conclusions: Preterms had a high prevalence of abnormal pulmonary function and lower pulmonary function in comparison to term infants. Prematurity, intrauterine growth restriction, respiratory support and recurrent wheezing were associated with abnormal pulmonary function. |
id |
UFMG_d6fad6561171c3576cc9b0e755de7a51 |
---|---|
oai_identifier_str |
oai:repositorio.ufmg.br:1843/48304 |
network_acronym_str |
UFMG |
network_name_str |
Repositório Institucional da UFMG |
repository_id_str |
|
spelling |
2022-12-21T14:52:08Z2022-12-21T14:52:08Z2018-031368387https://doi.org/10.1016/j.rmed.2018.02.0040954-6111http://hdl.handle.net/1843/48304https://orcid.org/0000-0001-5243-2436http://orcid.org/0000-0003-2173-4380https://orcid.org/0000-0001-9845-6097https://orcid.org/0000-0002-4748-6947https://orcid.org/0000-0002-3579-0861http://orcid.org/0000-0002-8407-1556Background: Pulmonary function in former preterm infants may be compromised during childhood. Objectives: To assess pulmonary function in very-low-birth-weight preterm infants at 6–12 months of corrected age and analyze the factors associated with abnormal pulmonary function. Methods: Cross-sectional study with preterm infants at 6–12 months of corrected age with birth weight <1500 g. Children with malformations or affected by neuromuscular and respiratory diseases were excluded. Forced expiratory flows were assessed using the chest compression technique, and volumes were measured by total body plethysmography. Pulmonary function parameters in preterm infants were compared to a control group of same-aged children born at term. Results: We studied 51 preterm and 37 infants born at term. Preterm infants had: gestational age at birth (30.0 ± 2.5 weeks), birth weight (1179 ± 247 g), 27.5% had bronchopulmonary dysplasia, and 45% received mechanical ventilation. Preterm infants had lower median z-scores in comparison to term infants for the following parameters (p < 0.05): FVC (−0.3 vs. 0.7), FEV0.5 (−0.5 vs. 0.9), FEV0.5/FVC (−0.6 vs. −0.5), FEF50 (−0.4 vs. 0.9), FEF75 (−0.3 vs. 0.8), FEF85 (−0.1 vs. 0.6) and FEF25-75 (−0.5 vs. 1.1). No term child had abnormal lung function, compared to 39.2% of preterm infants (p = 0.001). Factors associated with abnormal pulmonary function were lower gestational age at birth, small for gestational age, need for mechanical ventilation and presence of recurrent wheezing. Conclusions: Preterms had a high prevalence of abnormal pulmonary function and lower pulmonary function in comparison to term infants. Prematurity, intrauterine growth restriction, respiratory support and recurrent wheezing were associated with abnormal pulmonary function.engUniversidade Federal de Minas GeraisUFMGBrasilEEF - DEPARTAMENTO DE FISIOTERAPIARespiratory MedicineRecém-nascidoPrematurosPulmões - FisiologiaPletismografiaFatores de riscoChildInfantPrematurePulmonary functionPlethysmographyRisk factorsPulmonary function in former very low birth weight preterm infants in the first year of lifeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S0954611118300337?via%3DihubDaniela de Melo Miranda GonçalvesGustavo Falbo WandalsenAna Sílvia ScavaciniFernanda de Córdoba LanzaAna Lucia GoulartDirceu SoléAmélia Miyashiro Nunes dos Santosapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/48304/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALPulmonary function in former very low birth weight preterm infants.pdfPulmonary function in former very low birth weight preterm infants.pdfapplication/pdf268284https://repositorio.ufmg.br/bitstream/1843/48304/2/Pulmonary%20function%20in%20former%20very%20low%20birth%20weight%20preterm%20infants.pdf759b77f0999f0d776c6a56a806ea9c86MD521843/483042022-12-21 11:52:08.469oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-12-21T14:52:08Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Pulmonary function in former very low birth weight preterm infants in the first year of life |
title |
Pulmonary function in former very low birth weight preterm infants in the first year of life |
spellingShingle |
Pulmonary function in former very low birth weight preterm infants in the first year of life Daniela de Melo Miranda Gonçalves Child Infant Premature Pulmonary function Plethysmography Risk factors Recém-nascido Prematuros Pulmões - Fisiologia Pletismografia Fatores de risco |
title_short |
Pulmonary function in former very low birth weight preterm infants in the first year of life |
title_full |
Pulmonary function in former very low birth weight preterm infants in the first year of life |
title_fullStr |
Pulmonary function in former very low birth weight preterm infants in the first year of life |
title_full_unstemmed |
Pulmonary function in former very low birth weight preterm infants in the first year of life |
title_sort |
Pulmonary function in former very low birth weight preterm infants in the first year of life |
author |
Daniela de Melo Miranda Gonçalves |
author_facet |
Daniela de Melo Miranda Gonçalves Gustavo Falbo Wandalsen Ana Sílvia Scavacini Fernanda de Córdoba Lanza Ana Lucia Goulart Dirceu Solé Amélia Miyashiro Nunes dos Santos |
author_role |
author |
author2 |
Gustavo Falbo Wandalsen Ana Sílvia Scavacini Fernanda de Córdoba Lanza Ana Lucia Goulart Dirceu Solé Amélia Miyashiro Nunes dos Santos |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Daniela de Melo Miranda Gonçalves Gustavo Falbo Wandalsen Ana Sílvia Scavacini Fernanda de Córdoba Lanza Ana Lucia Goulart Dirceu Solé Amélia Miyashiro Nunes dos Santos |
dc.subject.por.fl_str_mv |
Child Infant Premature Pulmonary function Plethysmography Risk factors |
topic |
Child Infant Premature Pulmonary function Plethysmography Risk factors Recém-nascido Prematuros Pulmões - Fisiologia Pletismografia Fatores de risco |
dc.subject.other.pt_BR.fl_str_mv |
Recém-nascido Prematuros Pulmões - Fisiologia Pletismografia Fatores de risco |
description |
Background: Pulmonary function in former preterm infants may be compromised during childhood. Objectives: To assess pulmonary function in very-low-birth-weight preterm infants at 6–12 months of corrected age and analyze the factors associated with abnormal pulmonary function. Methods: Cross-sectional study with preterm infants at 6–12 months of corrected age with birth weight <1500 g. Children with malformations or affected by neuromuscular and respiratory diseases were excluded. Forced expiratory flows were assessed using the chest compression technique, and volumes were measured by total body plethysmography. Pulmonary function parameters in preterm infants were compared to a control group of same-aged children born at term. Results: We studied 51 preterm and 37 infants born at term. Preterm infants had: gestational age at birth (30.0 ± 2.5 weeks), birth weight (1179 ± 247 g), 27.5% had bronchopulmonary dysplasia, and 45% received mechanical ventilation. Preterm infants had lower median z-scores in comparison to term infants for the following parameters (p < 0.05): FVC (−0.3 vs. 0.7), FEV0.5 (−0.5 vs. 0.9), FEV0.5/FVC (−0.6 vs. −0.5), FEF50 (−0.4 vs. 0.9), FEF75 (−0.3 vs. 0.8), FEF85 (−0.1 vs. 0.6) and FEF25-75 (−0.5 vs. 1.1). No term child had abnormal lung function, compared to 39.2% of preterm infants (p = 0.001). Factors associated with abnormal pulmonary function were lower gestational age at birth, small for gestational age, need for mechanical ventilation and presence of recurrent wheezing. Conclusions: Preterms had a high prevalence of abnormal pulmonary function and lower pulmonary function in comparison to term infants. Prematurity, intrauterine growth restriction, respiratory support and recurrent wheezing were associated with abnormal pulmonary function. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-03 |
dc.date.accessioned.fl_str_mv |
2022-12-21T14:52:08Z |
dc.date.available.fl_str_mv |
2022-12-21T14:52:08Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/48304 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.rmed.2018.02.004 |
dc.identifier.issn.pt_BR.fl_str_mv |
0954-6111 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0001-5243-2436 http://orcid.org/0000-0003-2173-4380 https://orcid.org/0000-0001-9845-6097 https://orcid.org/0000-0002-4748-6947 https://orcid.org/0000-0002-3579-0861 http://orcid.org/0000-0002-8407-1556 |
url |
https://doi.org/10.1016/j.rmed.2018.02.004 http://hdl.handle.net/1843/48304 https://orcid.org/0000-0001-5243-2436 http://orcid.org/0000-0003-2173-4380 https://orcid.org/0000-0001-9845-6097 https://orcid.org/0000-0002-4748-6947 https://orcid.org/0000-0002-3579-0861 http://orcid.org/0000-0002-8407-1556 |
identifier_str_mv |
0954-6111 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Respiratory Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
EEF - DEPARTAMENTO DE FISIOTERAPIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Repositório Institucional da UFMG |
collection |
Repositório Institucional da UFMG |
bitstream.url.fl_str_mv |
https://repositorio.ufmg.br/bitstream/1843/48304/1/License.txt https://repositorio.ufmg.br/bitstream/1843/48304/2/Pulmonary%20function%20in%20former%20very%20low%20birth%20weight%20preterm%20infants.pdf |
bitstream.checksum.fl_str_mv |
fa505098d172de0bc8864fc1287ffe22 759b77f0999f0d776c6a56a806ea9c86 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
|
_version_ |
1801677066798628864 |