Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status

• Autor(a) principal: Paula Luize Camargos Fonseca
• Data de Publicação: 2022
• Outros Autores: Helena P. Coelho, Alana V. B. Costa, Walyson C. Costa, Alex F. de Carvalho, Bruna W. F. de Faria, Aline Brito de Lima, Eneida Santos de Oliveira, Carolina Senra Alves de Souza, Fernanda Gil de Souza, Rillery C. Dias, Filipe R. R. Moreira, Victor E. V. Geddes, Igor P. Godinho, Alessandro L. Gonçalves, Karine Lima Lourenço, Rubens D. M. Magalhães, Frederico Scott Varella Malta, Eva L. A. Medeiros, Fernanda Santos Mendes, Pedro H. B. de P. Mendes, Cristiane P. T. B. Mendonça, Rafael M. de Souza, Andre L. Menezes, Diego Menezes, Mariane Talon de Menezes, Lucyene Miguita Luiz, Rennan G. Moreira, Renata B. Peixoto, Daniel Costa Queiroz, Adriana A. Ribeiro, Ana Paula de B. Ribeiro, Juliana Wilke Saliba, Natalia Rocha Guimarães, Hugo I. Sato, Joice do P. Silva, Natiely Pereira Silva, Nuno R. Faria, Santuza Maria Ribeiro Teixeira, Flávio Guimarães da Fonseca, Ana Paula Salles Moura Fernandes, Danielle Alves Gomes Zauli, José Nélio Januario, Jaqueline Silva de Oliveira, Nara de Oliveira Carvalho, Felipe Campos de Melo Iani, Renato Santana de Aguiar, Renan Pedra de Souza, Talita Émile Ribeiro Adelino, Hugo José Alves, Luige Biciati Alvim, Darlan S. Candido
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://hdl.handle.net/1843/69771
• topic: Filogenia; Filogeografia; Vacinas contra COVID-19; Vacinação; SARS-CoV-2

The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first period of 2021. Many Brazilian regions detected the Delta variant after its first description and documented its spread. To monitor the introduction and spread of VOC Delta, we performed Polymerase Chain Reaction (PCR) genotyping and genome sequencing in ten regional sentinel units from June to October 2021 in the State of Minas Gerais (MG). We documented the introduction and spread of Delta, comprising 70 per cent of the cases 8 weeks later. Comparing the viral loads of the Gamma and Delta dominance periods, we provide additional evidence that the latter is more transmissible. The spread and dominance of Delta did not culminate in the increase in cases and deaths, suggesting that the vaccination may have restrained the epidemic growth. Analysis of 224 novel Delta genomes revealed that Rio de Janeiro state was the primary source for disseminating this variant in the state of MG. We present the establishment of Delta, providing evidence of its enhanced transmissibility and showing that this variant shift did not aggravate the epidemiological scenario in a high immunity setting.