Chemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.3390/plants10102084 http://hdl.handle.net/1843/56242 https://orcid.org/0000-0003-0909-769X https://orcid.org/0000-0001-5481-9618 https://orcid.org/0000-0002-0844-8702 https://orcid.org/0000-0002-7125-7431 https://orcid.org/0000-0001-7725-0970 https://orcid.org/0000-0002-6742-3652 |
Resumo: | Cyperus articulatus L. (Priprioca) is a plant of the Cyperaceae family traditionally used in traditional medicine in the Amazon region. Studies of the essential oil of this species have identified many terpene compounds. However, little is known about the possible uses of solid waste generated by the extraction of essential oils. This study aimed to investigate the chemical composition of volatile compounds and to evaluate the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the essential oil of C. articulatus L. rizhomes in experimental models in vitro using peritoneal macrophages of mice and human tumor cell lines. The analysis of the chemical composition of volatile compounds indicated the presence of sesquiterpenes and particularly sequiterpenic ketones as main constituents. The results showed that the treatment with ethanolic extract of C. articulatus L. reduced the activity of the enzyme arginase and proliferation of cancer cells (p < 0.0001). The extract also showed no cytotoxicity in macrophages in concentrations between 12.5; 25 and 50 mg/mL (p < 0.0001). The results indicated that the extract of C. articulatus L. exerts antiproliferative activity (p < 0.0001) with low toxicity on healthy cells in experimental models in vitro. |
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2023-07-14T19:13:46Z2023-07-14T19:13:46Z20211010https://doi.org/10.3390/plants101020842223-7747http://hdl.handle.net/1843/56242https://orcid.org/0000-0003-0909-769Xhttps://orcid.org/0000-0001-5481-9618https://orcid.org/0000-0002-0844-8702https://orcid.org/0000-0002-7125-7431https://orcid.org/0000-0001-7725-0970https://orcid.org/0000-0002-6742-3652Cyperus articulatus L. (Priprioca) is a plant of the Cyperaceae family traditionally used in traditional medicine in the Amazon region. Studies of the essential oil of this species have identified many terpene compounds. However, little is known about the possible uses of solid waste generated by the extraction of essential oils. This study aimed to investigate the chemical composition of volatile compounds and to evaluate the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the essential oil of C. articulatus L. rizhomes in experimental models in vitro using peritoneal macrophages of mice and human tumor cell lines. The analysis of the chemical composition of volatile compounds indicated the presence of sesquiterpenes and particularly sequiterpenic ketones as main constituents. The results showed that the treatment with ethanolic extract of C. articulatus L. reduced the activity of the enzyme arginase and proliferation of cancer cells (p < 0.0001). The extract also showed no cytotoxicity in macrophages in concentrations between 12.5; 25 and 50 mg/mL (p < 0.0001). The results indicated that the extract of C. articulatus L. exerts antiproliferative activity (p < 0.0001) with low toxicity on healthy cells in experimental models in vitro.Cyperus articulatus L. (Priprioca) é uma planta da família Cyperaceae tradicionalmente utilizada na medicina tradicional da região amazônica. Estudos do óleo essencial desta espécie identificaram muitos compostos de terpeno. No entanto, pouco se sabe sobre os possíveis usos dos resíduos sólidos gerados pela extração de óleos essenciais. Este estudo teve como objetivo investigar a composição química de compostos voláteis e avaliar a atividade antiproliferativa do extrato etanólico de resíduos sólidos gerados pela extração do óleo essencial de C. articulatus L. rizhomes em modelos experimentais in vitro utilizando macrófagos peritoneais de camundongos e linhagens de células tumorais humanas. A análise da composição química dos compostos voláteis indicou a presença de sesquiterpenos e principalmente cetonas sequiterpênicas como constituintes principais. Os resultados mostraram que o tratamento com extrato etanólico de C. articulatus L. reduziu a atividade da enzima arginase e a proliferação de células cancerígenas (p < 0,0001). O extrato também não apresentou citotoxicidade em macrófagos nas concentrações entre 12,5; 25 e 50 mg/mL (p < 0,0001). Os resultados indicaram que o extrato de C. articulatus L. exerce atividade antiproliferativa (p < 0,0001) com baixa toxicidade em células sadias em modelos experimentais in vitro.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPlantsPlantas MedicinaisCitotoxicidade imunológicaArginaseAntineoplásicosMedicinal plantCytotoxicityArginaseAntiproliferativeAnticancerChemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae)Composição química e atividade antiproliferativa do extrato etanólico de Cyperus articulatus L. (cyperaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.mdpi.com/2223-7747/10/10/2084Éden Bruno Sousa da SilvaLauro Euclides Soares BarataMichelly Rios ArévaloLeda Quercia VieiraWaldionê CastroAna Lúcia Tasca Gois RuizAdriana Della TorreKelly Christina Ferreira CastroAdilson SartorattoLeopoldo Clemente BarattoMaxwell Barbosa de SantanaAntonio Humberto Hamad MinervinoWaldiney Pires Moraesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56242/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALChemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae).pdfChemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae).pdfapplication/pdf297035https://repositorio.ufmg.br/bitstream/1843/56242/2/Chemical%20composition%20and%20antiproliferative%20activity%20of%20the%20ethanolic%20extract%20of%20Cyperus%20articulatus%20L.%20%28cyperaceae%29.pdf4d979f8e1f671c552abf453c5e8a1d07MD521843/562422023-07-14 16:13:46.645oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-14T19:13:46Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Chemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae) |
dc.title.alternative.pt_BR.fl_str_mv |
Composição química e atividade antiproliferativa do extrato etanólico de Cyperus articulatus L. (cyperaceae) |
title |
Chemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae) |
spellingShingle |
Chemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae) Éden Bruno Sousa da Silva Medicinal plant Cytotoxicity Arginase Antiproliferative Anticancer Plantas Medicinais Citotoxicidade imunológica Arginase Antineoplásicos |
title_short |
Chemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae) |
title_full |
Chemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae) |
title_fullStr |
Chemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae) |
title_full_unstemmed |
Chemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae) |
title_sort |
Chemical composition and antiproliferative activity of the ethanolic extract of Cyperus articulatus L. (cyperaceae) |
author |
Éden Bruno Sousa da Silva |
author_facet |
Éden Bruno Sousa da Silva Lauro Euclides Soares Barata Michelly Rios Arévalo Leda Quercia Vieira Waldionê Castro Ana Lúcia Tasca Gois Ruiz Adriana Della Torre Kelly Christina Ferreira Castro Adilson Sartoratto Leopoldo Clemente Baratto Maxwell Barbosa de Santana Antonio Humberto Hamad Minervino Waldiney Pires Moraes |
author_role |
author |
author2 |
Lauro Euclides Soares Barata Michelly Rios Arévalo Leda Quercia Vieira Waldionê Castro Ana Lúcia Tasca Gois Ruiz Adriana Della Torre Kelly Christina Ferreira Castro Adilson Sartoratto Leopoldo Clemente Baratto Maxwell Barbosa de Santana Antonio Humberto Hamad Minervino Waldiney Pires Moraes |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Éden Bruno Sousa da Silva Lauro Euclides Soares Barata Michelly Rios Arévalo Leda Quercia Vieira Waldionê Castro Ana Lúcia Tasca Gois Ruiz Adriana Della Torre Kelly Christina Ferreira Castro Adilson Sartoratto Leopoldo Clemente Baratto Maxwell Barbosa de Santana Antonio Humberto Hamad Minervino Waldiney Pires Moraes |
dc.subject.por.fl_str_mv |
Medicinal plant Cytotoxicity Arginase Antiproliferative Anticancer |
topic |
Medicinal plant Cytotoxicity Arginase Antiproliferative Anticancer Plantas Medicinais Citotoxicidade imunológica Arginase Antineoplásicos |
dc.subject.other.pt_BR.fl_str_mv |
Plantas Medicinais Citotoxicidade imunológica Arginase Antineoplásicos |
description |
Cyperus articulatus L. (Priprioca) is a plant of the Cyperaceae family traditionally used in traditional medicine in the Amazon region. Studies of the essential oil of this species have identified many terpene compounds. However, little is known about the possible uses of solid waste generated by the extraction of essential oils. This study aimed to investigate the chemical composition of volatile compounds and to evaluate the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the essential oil of C. articulatus L. rizhomes in experimental models in vitro using peritoneal macrophages of mice and human tumor cell lines. The analysis of the chemical composition of volatile compounds indicated the presence of sesquiterpenes and particularly sequiterpenic ketones as main constituents. The results showed that the treatment with ethanolic extract of C. articulatus L. reduced the activity of the enzyme arginase and proliferation of cancer cells (p < 0.0001). The extract also showed no cytotoxicity in macrophages in concentrations between 12.5; 25 and 50 mg/mL (p < 0.0001). The results indicated that the extract of C. articulatus L. exerts antiproliferative activity (p < 0.0001) with low toxicity on healthy cells in experimental models in vitro. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2023-07-14T19:13:46Z |
dc.date.available.fl_str_mv |
2023-07-14T19:13:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56242 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3390/plants10102084 |
dc.identifier.issn.pt_BR.fl_str_mv |
2223-7747 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0003-0909-769X https://orcid.org/0000-0001-5481-9618 https://orcid.org/0000-0002-0844-8702 https://orcid.org/0000-0002-7125-7431 https://orcid.org/0000-0001-7725-0970 https://orcid.org/0000-0002-6742-3652 |
url |
https://doi.org/10.3390/plants10102084 http://hdl.handle.net/1843/56242 https://orcid.org/0000-0003-0909-769X https://orcid.org/0000-0001-5481-9618 https://orcid.org/0000-0002-0844-8702 https://orcid.org/0000-0002-7125-7431 https://orcid.org/0000-0001-7725-0970 https://orcid.org/0000-0002-6742-3652 |
identifier_str_mv |
2223-7747 |
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eng |
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eng |
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Plants |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA |
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Universidade Federal de Minas Gerais |
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