Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | http://hdl.handle.net/1843/44379 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-08-19T11:16:56Z2022-08-19T11:16:56Z2017-03-0324986186810.2174/09298665246661707281559261875-5305http://hdl.handle.net/1843/44379CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorBackground: sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of obesity. Objectives: the present study aimed to assess the effects of SG on the metabolic and inflammatory profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet. Methods: male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and RAS components in adipose tissue were evaluated. Results: SG led to weight loss, decreased adiposity (p < 0.01) and a reduction in plasma glucose (p < 0.05), C-peptide (p < 0.05), insulin (p < 0.001) and total cholesterol (p < 0.05) levels. In addition, SG led to a decrease in the expression of tumor necrosis factor-alpha (TNF-α) (p < 0.01), interleukin- 6 (IL-6) (p < 0.001), angiotensinogen (AGT) (p < 0.001) and angiotensin converting enzyme (ACE) (p < 0.05) and increased the expression of angiotensin converting enzyme 2 (ACE2) (p < 0.05) in white adipose tissue. No statistically significant differences were observed for AT1 (p = 0.10) and Mas (p = 0.22) receptors. Conclusion: this study showed that SG leads to weight loss and improves metabolic parameters. Changes in the expression of RAS components and of inflammatory molecules in adipose tissue seem to play a role the before beneficial effects of the SG.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASProtein and Peptide LettersGastrectomiaSistema renina-angiotensinaCirurgia bariátricaObesidadeTecido adiposoEffects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://www.eurekaselect.com/article/85070Thaisa Soares CrespoJoão Marcus Oliveira AndradeAlanna Fernandes ParaísoDeborah de Farias LelisPablo Vinicyus Ferreira ChagasAntônio Sergio Barcala JorgeWagner Leite FerreiraAlfredo Maurício Batista de PaulaAndré Luiz Sena GuimarãesSergio Henrique Sousa Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44379/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALEffects of Sleeve Gastrectomy on the Metabolic Profile and on the Expression of Renin-Angiotensin System in Adipose Tissue of Obese Rats.pdfEffects of Sleeve Gastrectomy on the Metabolic Profile and on the Expression of Renin-Angiotensin System in Adipose Tissue of Obese Rats.pdfapplication/pdf5926900https://repositorio.ufmg.br/bitstream/1843/44379/2/Effects%20of%20Sleeve%20Gastrectomy%20on%20the%20Metabolic%20Profile%20and%20on%20the%20Expression%20of%20Renin-Angiotensin%20System%20in%20Adipose%20Tissue%20of%20Obese%20Rats.pdf015f7f9945648904061c304c65c3f7c3MD521843/443792022-08-19 08:16:57.1oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-19T11:16:57Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats |
| title |
Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats |
| spellingShingle |
Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats Thaisa Soares Crespo Gastrectomia Sistema renina-angiotensina Cirurgia bariátrica Obesidade Tecido adiposo |
| title_short |
Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats |
| title_full |
Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats |
| title_fullStr |
Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats |
| title_full_unstemmed |
Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats |
| title_sort |
Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats |
| author |
Thaisa Soares Crespo |
| author_facet |
Thaisa Soares Crespo João Marcus Oliveira Andrade Alanna Fernandes Paraíso Deborah de Farias Lelis Pablo Vinicyus Ferreira Chagas Antônio Sergio Barcala Jorge Wagner Leite Ferreira Alfredo Maurício Batista de Paula André Luiz Sena Guimarães Sergio Henrique Sousa Santos |
| author_role |
author |
| author2 |
João Marcus Oliveira Andrade Alanna Fernandes Paraíso Deborah de Farias Lelis Pablo Vinicyus Ferreira Chagas Antônio Sergio Barcala Jorge Wagner Leite Ferreira Alfredo Maurício Batista de Paula André Luiz Sena Guimarães Sergio Henrique Sousa Santos |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Thaisa Soares Crespo João Marcus Oliveira Andrade Alanna Fernandes Paraíso Deborah de Farias Lelis Pablo Vinicyus Ferreira Chagas Antônio Sergio Barcala Jorge Wagner Leite Ferreira Alfredo Maurício Batista de Paula André Luiz Sena Guimarães Sergio Henrique Sousa Santos |
| dc.subject.other.pt_BR.fl_str_mv |
Gastrectomia Sistema renina-angiotensina Cirurgia bariátrica Obesidade Tecido adiposo |
| topic |
Gastrectomia Sistema renina-angiotensina Cirurgia bariátrica Obesidade Tecido adiposo |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2017 |
| dc.date.issued.fl_str_mv |
2017-03-03 |
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2022-08-19T11:16:56Z |
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2022-08-19T11:16:56Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/1843/44379 |
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10.2174/0929866524666170728155926 |
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1875-5305 |
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10.2174/0929866524666170728155926 1875-5305 |
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http://hdl.handle.net/1843/44379 |
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eng |
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eng |
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Protein and Peptide Letters |
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openAccess |
| dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
| dc.publisher.department.fl_str_mv |
ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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