Inflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease

Detalhes bibliográficos
Autor(a) principal: Gabriela Lopes Martins
Data de Publicação: 2020
Outros Autores: Rita Carolina Figueiredo Duarte, Marat Alexandrovich Mukhamedyarov, András Palotás, Cláudia Natália Ferreira, Helton José dos Reis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: https://doi.org/10.3390/ijms21093226
http://hdl.handle.net/1843/51666
https://orcid.org/0000-0002-5152-8038
https://orcid.org/0000-0003-4545-6821
https://orcid.org/0000-0002-4055-701X
Resumo: Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanisms are unknown, the role of inflammatory processes and infectious agents have recently been implicated in both AD and AF, suggesting a common link between these maladies. Here, we present the main shared pathways underlying arrhythmia and memory loss. The overlapping predictive biomarkers and emerging joint pharmacological approaches are also discussed.
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spelling 2023-04-05T23:43:45Z2023-04-05T23:43:45Z2020-05-02219https://doi.org/10.3390/ijms210932261422-0067http://hdl.handle.net/1843/51666https://orcid.org/0000-0002-5152-8038https://orcid.org/0000-0003-4545-6821https://orcid.org/0000-0002-4055-701XAtrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanisms are unknown, the role of inflammatory processes and infectious agents have recently been implicated in both AD and AF, suggesting a common link between these maladies. Here, we present the main shared pathways underlying arrhythmia and memory loss. The overlapping predictive biomarkers and emerging joint pharmacological approaches are also discussed.A fibrilação atrial (FA) é uma das formas mais prevalentes de arritmia que acarreta um risco aumentado de acidente vascular cerebral que, por sua vez, está fortemente associado ao declínio cognitivo. A maioria dos casos de demência é causada pela doença de Alzheimer (DA) com patogênese obscura. Embora os mecanismos exatos sejam desconhecidos, o papel dos processos inflamatórios e dos agentes infecciosos foi recentemente implicado na DA e na FA, sugerindo uma ligação comum entre essas doenças. Aqui, apresentamos as principais vias compartilhadas subjacentes à arritmia e à perda de memória. A sobreposição de biomarcadores preditivos e abordagens farmacológicas conjuntas emergentes também são discutidas.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorOutra AgênciaengUniversidade Federal de Minas GeraisUFMGBrasilCOLTEC - COLEGIO TECNICOFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE FARMACOLOGIAInternational Journal of Molecular SciencesDoença de AlzheimerFibrilação atrialAnti-InflamatóriosArritmias cardíacasDemênciaCélulas endoteliaisBiomarcadoresAlzheimer’s diseaseAnti-inflammatory therapyArrhythmiaAtrial fibrillationDementiaEndothelial damageInfectionInflammationMicrobiomePredictive biomarkersInflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s diseaseProcessos inflamatórios e infecciosos servem como elos entre a fibrilação atrial e a doença de Alzheimerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.mdpi.com/1422-0067/21/9/3226Gabriela Lopes MartinsRita Carolina Figueiredo DuarteMarat Alexandrovich MukhamedyarovAndrás PalotásCláudia Natália FerreiraHelton José dos Reisapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/51666/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALInflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease.pdfInflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease.pdfapplication/pdf274801https://repositorio.ufmg.br/bitstream/1843/51666/2/Inflammatory%20and%20infectious%20processes%20serve%20as%20links%20between%20atrial%20fibrillation%20and%20Alzheimer%e2%80%99s%20disease.pdf4950628b3a1e7b466ebdc998df923c4aMD521843/516662023-04-05 20:43:45.596oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-04-05T23:43:45Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Inflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease
dc.title.alternative.pt_BR.fl_str_mv Processos inflamatórios e infecciosos servem como elos entre a fibrilação atrial e a doença de Alzheimer
title Inflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease
spellingShingle Inflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease
Gabriela Lopes Martins
Alzheimer’s disease
Anti-inflammatory therapy
Arrhythmia
Atrial fibrillation
Dementia
Endothelial damage
Infection
Inflammation
Microbiome
Predictive biomarkers
Doença de Alzheimer
Fibrilação atrial
Anti-Inflamatórios
Arritmias cardíacas
Demência
Células endoteliais
Biomarcadores
title_short Inflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease
title_full Inflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease
title_fullStr Inflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease
title_full_unstemmed Inflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease
title_sort Inflammatory and infectious processes serve as links between atrial fibrillation and Alzheimer’s disease
author Gabriela Lopes Martins
author_facet Gabriela Lopes Martins
Rita Carolina Figueiredo Duarte
Marat Alexandrovich Mukhamedyarov
András Palotás
Cláudia Natália Ferreira
Helton José dos Reis
author_role author
author2 Rita Carolina Figueiredo Duarte
Marat Alexandrovich Mukhamedyarov
András Palotás
Cláudia Natália Ferreira
Helton José dos Reis
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Gabriela Lopes Martins
Rita Carolina Figueiredo Duarte
Marat Alexandrovich Mukhamedyarov
András Palotás
Cláudia Natália Ferreira
Helton José dos Reis
dc.subject.por.fl_str_mv Alzheimer’s disease
Anti-inflammatory therapy
Arrhythmia
Atrial fibrillation
Dementia
Endothelial damage
Infection
Inflammation
Microbiome
Predictive biomarkers
topic Alzheimer’s disease
Anti-inflammatory therapy
Arrhythmia
Atrial fibrillation
Dementia
Endothelial damage
Infection
Inflammation
Microbiome
Predictive biomarkers
Doença de Alzheimer
Fibrilação atrial
Anti-Inflamatórios
Arritmias cardíacas
Demência
Células endoteliais
Biomarcadores
dc.subject.other.pt_BR.fl_str_mv Doença de Alzheimer
Fibrilação atrial
Anti-Inflamatórios
Arritmias cardíacas
Demência
Células endoteliais
Biomarcadores
description Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanisms are unknown, the role of inflammatory processes and infectious agents have recently been implicated in both AD and AF, suggesting a common link between these maladies. Here, we present the main shared pathways underlying arrhythmia and memory loss. The overlapping predictive biomarkers and emerging joint pharmacological approaches are also discussed.
publishDate 2020
dc.date.issued.fl_str_mv 2020-05-02
dc.date.accessioned.fl_str_mv 2023-04-05T23:43:45Z
dc.date.available.fl_str_mv 2023-04-05T23:43:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/51666
dc.identifier.doi.pt_BR.fl_str_mv https://doi.org/10.3390/ijms21093226
dc.identifier.issn.pt_BR.fl_str_mv 1422-0067
dc.identifier.orcid.pt_BR.fl_str_mv https://orcid.org/0000-0002-5152-8038
https://orcid.org/0000-0003-4545-6821
https://orcid.org/0000-0002-4055-701X
url https://doi.org/10.3390/ijms21093226
http://hdl.handle.net/1843/51666
https://orcid.org/0000-0002-5152-8038
https://orcid.org/0000-0003-4545-6821
https://orcid.org/0000-0002-4055-701X
identifier_str_mv 1422-0067
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv International Journal of Molecular Sciences
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv COLTEC - COLEGIO TECNICO
FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
ICB - DEPARTAMENTO DE FARMACOLOGIA
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/51666/1/License.txt
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