Efeito da suplementação de proteína na composição corporal, gasto energético e parâmetros bioquímicos de pacientes submetidos à cirurgia bariátrica

Detalhes bibliográficos
Autor(a) principal: Hirla Karen Fialho Henriques
Data de Publicação: 2023
Tipo de documento: Tese
Idioma: por
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/59938
Resumo: Bariatric surgery (BS) is the most successful method for weight loss in patients with grade III obesity and morbidities. However, patients undergoing BC often do not reach the recommended protein intake. Thus, protein supplements could minimize the loss of muscle mass by preventing protein malnutrition. Whey protein has high biological value, with high content of branched-chain amino acids that stimulate protein synthesis and reduce the loss of muscle mass observed in hypocaloric diets. Thus, whey protein would contribute to maintain body composition and prevent muscle loss. Our aim was to evaluate the effect of whey protein supplementation for 8 weeks in female patients in the late postoperative period of BS, regarding nutritional, metabolic and inflammatory status. After the eight weeks of experiment, there was an increase in lean mass, muscle thickness and a reduction in fat mass and fat percentage in the Whey group compared to the initial time, a result not observed in the control group. There was no difference in biochemical parameters, except for the increase in fasting blood glucose in the Malto group, which did not occur in the Whey group. In addition, there was a reduction in inflammation in the protein-supplemented group compared to the initial time. No differences were observed in handgrip strength and gait speed in the groups, as well as in energy expenditure in both groups. We conclude that whey protein supplementation can reduce fat-free mass loss and increase body fat mass regardless of changes in BMI evolution in the late postoperative period of bariatric surgery. In addition, our findings suggest that isolated milk protein supplementation can bring benefits in reducing inflammation, in addition to contributing to the maintenance of a healthy diet.
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spelling Efeito da suplementação de proteína na composição corporal, gasto energético e parâmetros bioquímicos de pacientes submetidos à cirurgia bariátricacirurgia bariátricawhey proteinmassa magramassa gordainflamaçãoBioquímica e imunologiaCirurgia BariátricaEstado NutricionalSuplementos NutricionaisProteinasMetabolismoInflamaçãoBariatric surgery (BS) is the most successful method for weight loss in patients with grade III obesity and morbidities. However, patients undergoing BC often do not reach the recommended protein intake. Thus, protein supplements could minimize the loss of muscle mass by preventing protein malnutrition. Whey protein has high biological value, with high content of branched-chain amino acids that stimulate protein synthesis and reduce the loss of muscle mass observed in hypocaloric diets. Thus, whey protein would contribute to maintain body composition and prevent muscle loss. Our aim was to evaluate the effect of whey protein supplementation for 8 weeks in female patients in the late postoperative period of BS, regarding nutritional, metabolic and inflammatory status. After the eight weeks of experiment, there was an increase in lean mass, muscle thickness and a reduction in fat mass and fat percentage in the Whey group compared to the initial time, a result not observed in the control group. There was no difference in biochemical parameters, except for the increase in fasting blood glucose in the Malto group, which did not occur in the Whey group. In addition, there was a reduction in inflammation in the protein-supplemented group compared to the initial time. No differences were observed in handgrip strength and gait speed in the groups, as well as in energy expenditure in both groups. We conclude that whey protein supplementation can reduce fat-free mass loss and increase body fat mass regardless of changes in BMI evolution in the late postoperative period of bariatric surgery. In addition, our findings suggest that isolated milk protein supplementation can bring benefits in reducing inflammation, in addition to contributing to the maintenance of a healthy diet.Pacientes submetidos à cirurgia bariátrica (CB) geralmente não atingem a recomendação de ingestão de proteínas, levando a perda de massa muscular. Assim, suplementos proteicos poderiam minimizar a perda e melhorar a composição corporal. Nosso objetivo foi avaliar o efeito da suplementação de whey protein por 8 semanas em mulheres no pós-operatório tardio de CB, quanto ao estado nutricional, metabólico e inflamatório. 24 mulheres foram suplementadas com 30g de whey protein por oito semanas em um estudo duplo-cego, controlado por placebo e não randomizado. Composição corporal, consumo alimentar, gasto energético, exames bioquímicos, espessura muscular, velocidade da marcha foram avaliados antes, durante e ao final do estudo. Observou-se aumento da massa magra, espessura muscular e redução da massa gorda e do percentual de gordura no grupo Whey, resultado não observado no grupo controle. Não houve diferença nos parâmetros bioquímicos, exceto pelo aumento da glicemia de jejum no grupo Malto, o que não ocorreu no grupo Whey. Houve redução da inflamação no grupo suplementado com a proteína em relação ao tempo inicial. Não houve alteração na força de preensão palmar e velocidade da marcha, bem como no gasto energético em ambos os grupos. Concluímos que a suplementação com whey protein pode reduzir a perda de massa livre de gordura e aumentar a massa gorda corporal independentemente das mudanças na evolução do IMC no pós-operatório tardio da cirurgia bariátrica. Além disso, nossos achados sugerem que a suplementação da proteína isolada do leite pode melhorar parâmetros inflamatórios e contribuir na manutenção de uma dieta saudável.FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisUniversidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMGJacqueline Isaura Alvarez Leitehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4723009A8&tokenCaptchar=03AFcWeA52IJYM-E65ezSQUwHLgvthXoFr-VzR-JU-O1jqT9QXl5BJT_-qnk8Q95DqPuBCd-xcYDKefNk-qjekiFfu10G_qhbiLqye3JSeQdpoRbAX_CEuob-ROmdPQ60A5oOCLvW4GQv4DmweAcB_AXGwB1eZZZenu8msH9VVdZoBhj827xvh7wgvOZG_B18DeuChSvXE40RrxlVkkQUMp7SKw2qFylFqs4MCEextXGP-60DLSaEA9kmETDl0WC1bE2oCB_BoSYaxZqo_FeN4kOxlTlaPTZQNIRaHeu1w2YA3IT_dIUuv7I8mir-KQZ7LuRLCw3Km9ayJut4uxY8UURuHZro8s7IfiKeC3C4tx2rTTdZqjGgkb53rr_74SNoesGv5ncJXvWvVi981F-kp_Egl1ZNfCW3SD8dndz9QvphvfB_qVWZcSBN-h7eQLkLeUfQsQBEcQgfWRryOjWY2a82CTm7vd1iWlRzL_bV0H1pbRff8slQVnK5Z5vq1YIAKp1sh8-gPFq7bnD6HgAQf0nbsNubeTYV-NGoAdEmVS1iin4Xf5AkNSenGKRjMMWx_5UUrqYWnPv5WHirla Karen Fialho Henriques2023-10-24T16:06:02Z2023-10-24T16:06:02Z2023-09-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/1843/59938porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2023-10-24T16:06:02Zoai:repositorio.ufmg.br:1843/59938Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2023-10-24T16:06:02Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Efeito da suplementação de proteína na composição corporal, gasto energético e parâmetros bioquímicos de pacientes submetidos à cirurgia bariátrica
title Efeito da suplementação de proteína na composição corporal, gasto energético e parâmetros bioquímicos de pacientes submetidos à cirurgia bariátrica
spellingShingle Efeito da suplementação de proteína na composição corporal, gasto energético e parâmetros bioquímicos de pacientes submetidos à cirurgia bariátrica
Hirla Karen Fialho Henriques
cirurgia bariátrica
whey protein
massa magra
massa gorda
inflamação
Bioquímica e imunologia
Cirurgia Bariátrica
Estado Nutricional
Suplementos Nutricionais
Proteinas
Metabolismo
Inflamação
title_short Efeito da suplementação de proteína na composição corporal, gasto energético e parâmetros bioquímicos de pacientes submetidos à cirurgia bariátrica
title_full Efeito da suplementação de proteína na composição corporal, gasto energético e parâmetros bioquímicos de pacientes submetidos à cirurgia bariátrica
title_fullStr Efeito da suplementação de proteína na composição corporal, gasto energético e parâmetros bioquímicos de pacientes submetidos à cirurgia bariátrica
title_full_unstemmed Efeito da suplementação de proteína na composição corporal, gasto energético e parâmetros bioquímicos de pacientes submetidos à cirurgia bariátrica
title_sort Efeito da suplementação de proteína na composição corporal, gasto energético e parâmetros bioquímicos de pacientes submetidos à cirurgia bariátrica
author Hirla Karen Fialho Henriques
author_facet Hirla Karen Fialho Henriques
author_role author
dc.contributor.none.fl_str_mv Jacqueline Isaura Alvarez Leite
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4723009A8&tokenCaptchar=03AFcWeA52IJYM-E65ezSQUwHLgvthXoFr-VzR-JU-O1jqT9QXl5BJT_-qnk8Q95DqPuBCd-xcYDKefNk-qjekiFfu10G_qhbiLqye3JSeQdpoRbAX_CEuob-ROmdPQ60A5oOCLvW4GQv4DmweAcB_AXGwB1eZZZenu8msH9VVdZoBhj827xvh7wgvOZG_B18DeuChSvXE40RrxlVkkQUMp7SKw2qFylFqs4MCEextXGP-60DLSaEA9kmETDl0WC1bE2oCB_BoSYaxZqo_FeN4kOxlTlaPTZQNIRaHeu1w2YA3IT_dIUuv7I8mir-KQZ7LuRLCw3Km9ayJut4uxY8UURuHZro8s7IfiKeC3C4tx2rTTdZqjGgkb53rr_74SNoesGv5ncJXvWvVi981F-kp_Egl1ZNfCW3SD8dndz9QvphvfB_qVWZcSBN-h7eQLkLeUfQsQBEcQgfWRryOjWY2a82CTm7vd1iWlRzL_bV0H1pbRff8slQVnK5Z5vq1YIAKp1sh8-gPFq7bnD6HgAQf0nbsNubeTYV-NGoAdEmVS1iin4Xf5AkNSenGKRjMMWx_5UUrqYWnPv5W
dc.contributor.author.fl_str_mv Hirla Karen Fialho Henriques
dc.subject.por.fl_str_mv cirurgia bariátrica
whey protein
massa magra
massa gorda
inflamação
Bioquímica e imunologia
Cirurgia Bariátrica
Estado Nutricional
Suplementos Nutricionais
Proteinas
Metabolismo
Inflamação
topic cirurgia bariátrica
whey protein
massa magra
massa gorda
inflamação
Bioquímica e imunologia
Cirurgia Bariátrica
Estado Nutricional
Suplementos Nutricionais
Proteinas
Metabolismo
Inflamação
description Bariatric surgery (BS) is the most successful method for weight loss in patients with grade III obesity and morbidities. However, patients undergoing BC often do not reach the recommended protein intake. Thus, protein supplements could minimize the loss of muscle mass by preventing protein malnutrition. Whey protein has high biological value, with high content of branched-chain amino acids that stimulate protein synthesis and reduce the loss of muscle mass observed in hypocaloric diets. Thus, whey protein would contribute to maintain body composition and prevent muscle loss. Our aim was to evaluate the effect of whey protein supplementation for 8 weeks in female patients in the late postoperative period of BS, regarding nutritional, metabolic and inflammatory status. After the eight weeks of experiment, there was an increase in lean mass, muscle thickness and a reduction in fat mass and fat percentage in the Whey group compared to the initial time, a result not observed in the control group. There was no difference in biochemical parameters, except for the increase in fasting blood glucose in the Malto group, which did not occur in the Whey group. In addition, there was a reduction in inflammation in the protein-supplemented group compared to the initial time. No differences were observed in handgrip strength and gait speed in the groups, as well as in energy expenditure in both groups. We conclude that whey protein supplementation can reduce fat-free mass loss and increase body fat mass regardless of changes in BMI evolution in the late postoperative period of bariatric surgery. In addition, our findings suggest that isolated milk protein supplementation can bring benefits in reducing inflammation, in addition to contributing to the maintenance of a healthy diet.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-24T16:06:02Z
2023-10-24T16:06:02Z
2023-09-12
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/59938
url http://hdl.handle.net/1843/59938
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
Programa de Pós-Graduação em Bioquímica e Imunologia
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
Programa de Pós-Graduação em Bioquímica e Imunologia
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
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