Synthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1016/j.ijbiomac.2019.04.006 http://hdl.handle.net/1843/47231 https://orcid.org/0000-0002-8798-4182 https://orcid.org/0000-0002-3032-495X https://orcid.org/0000-0003-1526-2508 https://orcid.org/0000-0003-2273-2993 https://orcid.org/0000-0001-6665-8647 https://orcid.org/0000-0002-7562-0285 https://orcid.org/0000-0003-3264-337X |
Resumo: | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
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2022-11-16T13:16:50Z2022-11-16T13:16:50Z2019132677691https://doi.org/10.1016/j.ijbiomac.2019.04.00601418130http://hdl.handle.net/1843/47231https://orcid.org/0000-0002-8798-4182https://orcid.org/0000-0002-3032-495Xhttps://orcid.org/0000-0003-1526-2508https://orcid.org/0000-0003-2273-2993https://orcid.org/0000-0001-6665-8647https://orcid.org/0000-0002-7562-0285https://orcid.org/0000-0003-3264-337XFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e ProjetosNovel core-shell superparamagnetic nanofluids composed of magnetic iron oxide (Fe3O4, MION) and cobalt-doped (CoxFe3-xO4, Co-MION) nanoparticles functionalized with carboxymethyl cellulose (CMC) ligands were designed and produced via green colloidal aqueous process. The effect of the degree of substitution (DS = 0.7 and 1.2) and molecular mass (Mw) of CMC and cobalt doping concentration on the physicochemical and magnetic properties of these nanoconjugates were comprehensively investigated using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction, transmission electron microscopy (TEM) with selected area electron diffraction, X-ray fluorescence, dynamic light scattering (DLS), zeta potential (ZP) analysis, vibrating sample magnetometry (VSM) and electron paramagnetic resonance spectroscopy (EPR). The results demonstrated the effect of concentration of carboxylate groups and Mw of CMC on the hydrodynamic dimension, zeta potential, and generated heat by magnetic hyperthermia of MION nanoconjugates. Co-doping of MION showed significant alteration of the electrostatic balance of charges of the nanoconjugates interpreted as effect of surface interactions. Moreover, the VSM and EPR results proved the superparamagnetic properties of these nanocolloids, which were affected by the presence of CMC and Co-doping of iron oxide nanoparticles. These magnetic nanohybrids behaved as nanoheaters for killing brain cancer cells in vitro with prospective future applications in oncology and nanomedicine.engUniversidade Federal de Minas GeraisUFMGBrasilENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICAICX - DEPARTAMENTO DE FÍSICAInternational Journal of Biological MacromoleculesPolissacarídeosNanotecnologiaNanopartículas magnéticasNanocompósitosPolysaccharideCarboxymethyl celluloseGreen nanotechnologyMagnetic nanoparticleNanocompositeSynthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S0141813019305537Alice Gameiro LeonelHerman Sander MansurAlexandra Ancelmo Piscitelli MansurAnderson Caires de JesusSandhra Maria de CarvalhoKlaus Wilhelm Heinrich KrambrockLuis Eugenio Fernandez OutonJosé Domingos Ardissonapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALSynthesis and characterization of iron oxide nanoparticles.pdfSynthesis and characterization of iron oxide nanoparticles.pdfapplication/pdf4088057https://repositorio.ufmg.br/bitstream/1843/47231/2/Synthesis%20and%20characterization%20of%20iron%20oxide%20nanoparticles.pdf2513901fbf83d81a643d5c5c9882566cMD52LICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/47231/1/License.txtfa505098d172de0bc8864fc1287ffe22MD511843/472312022-11-16 10:16:50.964oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-11-16T13:16:50Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Synthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro |
| title |
Synthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro |
| spellingShingle |
Synthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro Alice Gameiro Leonel Polysaccharide Carboxymethyl cellulose Green nanotechnology Magnetic nanoparticle Nanocomposite Polissacarídeos Nanotecnologia Nanopartículas magnéticas Nanocompósitos |
| title_short |
Synthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro |
| title_full |
Synthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro |
| title_fullStr |
Synthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro |
| title_full_unstemmed |
Synthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro |
| title_sort |
Synthesis and characterization of iron oxide nanoparticles/carboxymethyl cellulose core-shell nanohybrids for killing cancer cells in vitro |
| author |
Alice Gameiro Leonel |
| author_facet |
Alice Gameiro Leonel Herman Sander Mansur Alexandra Ancelmo Piscitelli Mansur Anderson Caires de Jesus Sandhra Maria de Carvalho Klaus Wilhelm Heinrich Krambrock Luis Eugenio Fernandez Outon José Domingos Ardisson |
| author_role |
author |
| author2 |
Herman Sander Mansur Alexandra Ancelmo Piscitelli Mansur Anderson Caires de Jesus Sandhra Maria de Carvalho Klaus Wilhelm Heinrich Krambrock Luis Eugenio Fernandez Outon José Domingos Ardisson |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Alice Gameiro Leonel Herman Sander Mansur Alexandra Ancelmo Piscitelli Mansur Anderson Caires de Jesus Sandhra Maria de Carvalho Klaus Wilhelm Heinrich Krambrock Luis Eugenio Fernandez Outon José Domingos Ardisson |
| dc.subject.por.fl_str_mv |
Polysaccharide Carboxymethyl cellulose Green nanotechnology Magnetic nanoparticle Nanocomposite |
| topic |
Polysaccharide Carboxymethyl cellulose Green nanotechnology Magnetic nanoparticle Nanocomposite Polissacarídeos Nanotecnologia Nanopartículas magnéticas Nanocompósitos |
| dc.subject.other.pt_BR.fl_str_mv |
Polissacarídeos Nanotecnologia Nanopartículas magnéticas Nanocompósitos |
| description |
FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
| publishDate |
2019 |
| dc.date.issued.fl_str_mv |
2019 |
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2022-11-16T13:16:50Z |
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2022-11-16T13:16:50Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/1843/47231 |
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https://doi.org/10.1016/j.ijbiomac.2019.04.006 |
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01418130 |
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https://orcid.org/0000-0002-8798-4182 https://orcid.org/0000-0002-3032-495X https://orcid.org/0000-0003-1526-2508 https://orcid.org/0000-0003-2273-2993 https://orcid.org/0000-0001-6665-8647 https://orcid.org/0000-0002-7562-0285 https://orcid.org/0000-0003-3264-337X |
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https://doi.org/10.1016/j.ijbiomac.2019.04.006 http://hdl.handle.net/1843/47231 https://orcid.org/0000-0002-8798-4182 https://orcid.org/0000-0002-3032-495X https://orcid.org/0000-0003-1526-2508 https://orcid.org/0000-0003-2273-2993 https://orcid.org/0000-0001-6665-8647 https://orcid.org/0000-0002-7562-0285 https://orcid.org/0000-0003-3264-337X |
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01418130 |
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eng |
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eng |
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International Journal of Biological Macromolecules |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICA ICX - DEPARTAMENTO DE FÍSICA |
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Universidade Federal de Minas Gerais |
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