Amusia and its electrophysiological correlates in neurofibromatosis type 1

• Autor(a) principal: Bruno Cézar Lage Cota
• Data de Publicação: 2018
• Outros Autores: Luciana Macedo de Rezende, João Gabriel Marques Fonseca, Luiz Oswaldo Carneiro Rodrigues, Nilton Alves de Rezende, Pollyanna Alves Batista
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://hdl.handle.net/1843/62659
• topic: Neurofibromatosis 1; Evoked Potentials, Auditory; Music; Auditory perceptual disorders; Pitch discrimination; Neurofibromatosis 1; Music; Evoked Potentials, Auditory; Pitch Discrimination; Auditory Perceptual Disorders

Auditory processing deficits are common in people with neurofibromatosis type 1 (NF1) and they often report difficulties in musical performance. Objective: We investigated whether NF1 could be associated with amusia as well as with some impairment of primary auditory cortex activity. Methods: Eighteen people with NF1 and 22 healthy volunteers, matched for age, sex and educational level, were evaluated with the Montreal Battery Evaluation of Amusia – short version. The integrity of cortical primary auditory processing areas was evaluated by evoked potential mismatch negativity. Results: Amusia was correlated with NF1 (p = 0.001, odds ratio = 42.0, confidence interval 4.5–39.6). Patients with NF1 exhibited a greater prevalence of amusia than healthy controls (67% vs. 4.5%) and difficulties in both melodic and temporal music perception. Worse performance on the Montreal Battery Evaluation of Amusia was correlated with a greater mismatch negativity latency in NF1 group. Conclusions: Amusia is a common feature in NF1 and may result from impairment of activity in primary auditory processing areas.