Increased insulin sensitivity in individuals with neurofibromatosis type 1.
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/60801 |
Resumo: | Objects: To compare insulin resistance (IR) and metabolic aspects of patients with neurofibromatosis type 1 (NF1) and individuals without the disease. Subjects and methods: Forty patients with NF1 were matched by sex, age, and body mass index (BMI) to 40 controls from the community. Blood samples were collected for biochemical assessment. Homeostasis model assessment adiponectin (HOMA-AD), Homeostasis model assessment insulin resistance (HOMA-IR), and adiponectin/leptin ratio (ALR) were used to identify IR. Results: The median HOMA-IR values were similar between the groups. However, the HOMA-AD value was significantly lower and the ALR significantly higher in the NF1 group. Fasting blood glucose (FBG), leptin, and visfatin levels of patients with NF1 were significantly lower, although adiponectin levels were significantly higher than those in the controls. Fasting insulin and blood glucose levels 2 hours after administration of 75 g of dextrose, glycated hemoglobin, and resistin showed no significant differences between groups. The HOMA-AD correlated with BMI, FBG, blood glucose levels 2 hours after administration of 75 g of dextrose, fasting insulin, glycated hemoglobin, adiponectin, leptin, visfatin, ALR, and HOMA-IR. The ALR correlated with BMI leptin, visfatin, and adiponectin. Conclusions: Lower levels of FBG, leptin, visfatin, and HOMA-AD, and higher adiponectin levels and ALR may be related to increased insulin sensitivity and lower occurrence of type 2 diabetes mellitus in patients with NF1. |
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2023-11-10T20:33:50Z2023-11-10T20:33:50Z20186214146doi.org/10.20945/2359-399700000000729694637http://hdl.handle.net/1843/60801Objects: To compare insulin resistance (IR) and metabolic aspects of patients with neurofibromatosis type 1 (NF1) and individuals without the disease. Subjects and methods: Forty patients with NF1 were matched by sex, age, and body mass index (BMI) to 40 controls from the community. Blood samples were collected for biochemical assessment. Homeostasis model assessment adiponectin (HOMA-AD), Homeostasis model assessment insulin resistance (HOMA-IR), and adiponectin/leptin ratio (ALR) were used to identify IR. Results: The median HOMA-IR values were similar between the groups. However, the HOMA-AD value was significantly lower and the ALR significantly higher in the NF1 group. Fasting blood glucose (FBG), leptin, and visfatin levels of patients with NF1 were significantly lower, although adiponectin levels were significantly higher than those in the controls. Fasting insulin and blood glucose levels 2 hours after administration of 75 g of dextrose, glycated hemoglobin, and resistin showed no significant differences between groups. The HOMA-AD correlated with BMI, FBG, blood glucose levels 2 hours after administration of 75 g of dextrose, fasting insulin, glycated hemoglobin, adiponectin, leptin, visfatin, ALR, and HOMA-IR. The ALR correlated with BMI leptin, visfatin, and adiponectin. Conclusions: Lower levels of FBG, leptin, visfatin, and HOMA-AD, and higher adiponectin levels and ALR may be related to increased insulin sensitivity and lower occurrence of type 2 diabetes mellitus in patients with NF1.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE PEDIATRIAArchives of Endocrinology and MetabolismBlood GlucoseNeurofibromatosis 1Diabetes MellitusInsulin ResistanceBlood GlucoseNeurofibromatosis 1Diabetes MellitusInsulin ResistanceIncreased insulin sensitivity in individuals with neurofibromatosis type 1.ESTIMULAÇÃO TRANSCRANIANA POR CORRENTE CONTÍNUA (ETCC) E ASSIMETRIAS MANUAIS: O EFEITO DA ESTIMULAÇÃO NA DESTREZA MANUALinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.20945/2359-3997000000007as Martinsak Jansencm MatosLuiz Oswaldo RodriguesDébora Marques de MirandaNilton Rezende Alvesapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60801/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALIncreased insulin sensitivity pdfa.pdfIncreased insulin sensitivity pdfa.pdfapplication/pdf111597https://repositorio.ufmg.br/bitstream/1843/60801/2/Increased%20insulin%20sensitivity%20pdfa.pdfaf41f50c367227d739ce499c92d4b92aMD521843/608012023-11-10 17:41:33.362oai:repositorio.ufmg.br:1843/60801Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-11-10T20:41:33Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Increased insulin sensitivity in individuals with neurofibromatosis type 1. |
dc.title.alternative.pt_BR.fl_str_mv |
ESTIMULAÇÃO TRANSCRANIANA POR CORRENTE CONTÍNUA (ETCC) E ASSIMETRIAS MANUAIS: O EFEITO DA ESTIMULAÇÃO NA DESTREZA MANUAL |
title |
Increased insulin sensitivity in individuals with neurofibromatosis type 1. |
spellingShingle |
Increased insulin sensitivity in individuals with neurofibromatosis type 1. as Martins Blood Glucose Neurofibromatosis 1 Diabetes Mellitus Insulin Resistance Blood Glucose Neurofibromatosis 1 Diabetes Mellitus Insulin Resistance |
title_short |
Increased insulin sensitivity in individuals with neurofibromatosis type 1. |
title_full |
Increased insulin sensitivity in individuals with neurofibromatosis type 1. |
title_fullStr |
Increased insulin sensitivity in individuals with neurofibromatosis type 1. |
title_full_unstemmed |
Increased insulin sensitivity in individuals with neurofibromatosis type 1. |
title_sort |
Increased insulin sensitivity in individuals with neurofibromatosis type 1. |
author |
as Martins |
author_facet |
as Martins ak Jansen cm Matos Luiz Oswaldo Rodrigues Débora Marques de Miranda Nilton Rezende Alves |
author_role |
author |
author2 |
ak Jansen cm Matos Luiz Oswaldo Rodrigues Débora Marques de Miranda Nilton Rezende Alves |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
as Martins ak Jansen cm Matos Luiz Oswaldo Rodrigues Débora Marques de Miranda Nilton Rezende Alves |
dc.subject.por.fl_str_mv |
Blood Glucose Neurofibromatosis 1 Diabetes Mellitus Insulin Resistance |
topic |
Blood Glucose Neurofibromatosis 1 Diabetes Mellitus Insulin Resistance Blood Glucose Neurofibromatosis 1 Diabetes Mellitus Insulin Resistance |
dc.subject.other.pt_BR.fl_str_mv |
Blood Glucose Neurofibromatosis 1 Diabetes Mellitus Insulin Resistance |
description |
Objects: To compare insulin resistance (IR) and metabolic aspects of patients with neurofibromatosis type 1 (NF1) and individuals without the disease. Subjects and methods: Forty patients with NF1 were matched by sex, age, and body mass index (BMI) to 40 controls from the community. Blood samples were collected for biochemical assessment. Homeostasis model assessment adiponectin (HOMA-AD), Homeostasis model assessment insulin resistance (HOMA-IR), and adiponectin/leptin ratio (ALR) were used to identify IR. Results: The median HOMA-IR values were similar between the groups. However, the HOMA-AD value was significantly lower and the ALR significantly higher in the NF1 group. Fasting blood glucose (FBG), leptin, and visfatin levels of patients with NF1 were significantly lower, although adiponectin levels were significantly higher than those in the controls. Fasting insulin and blood glucose levels 2 hours after administration of 75 g of dextrose, glycated hemoglobin, and resistin showed no significant differences between groups. The HOMA-AD correlated with BMI, FBG, blood glucose levels 2 hours after administration of 75 g of dextrose, fasting insulin, glycated hemoglobin, adiponectin, leptin, visfatin, ALR, and HOMA-IR. The ALR correlated with BMI leptin, visfatin, and adiponectin. Conclusions: Lower levels of FBG, leptin, visfatin, and HOMA-AD, and higher adiponectin levels and ALR may be related to increased insulin sensitivity and lower occurrence of type 2 diabetes mellitus in patients with NF1. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2023-11-10T20:33:50Z |
dc.date.available.fl_str_mv |
2023-11-10T20:33:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/60801 |
dc.identifier.doi.pt_BR.fl_str_mv |
doi.org/10.20945/2359-3997000000007 |
dc.identifier.issn.pt_BR.fl_str_mv |
29694637 |
identifier_str_mv |
doi.org/10.20945/2359-3997000000007 29694637 |
url |
http://hdl.handle.net/1843/60801 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Archives of Endocrinology and Metabolism |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE PEDIATRIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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