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Luciana Diniz Silvahttp://lattes.cnpq.br/8491363243596537Gilda Aparecida FerreiraJuliana Maria Trindade BezerraClaudia Alves CoutoCristina Costa Duarte LannaLucilene Rezende Anastáciohttp://lattes.cnpq.br/8475267807506043Thais Pontello de Vries2024-03-12T13:56:50Z2024-03-12T13:56:50Z2021-03-17http://hdl.handle.net/1843/65720Introdução: Sarcopenia é achado relevante em pacientes com hepatite C crônica (HCV). No entanto, os mecanismos biológicos envolvidos na perda da massa muscular esquelética não foram completamente esclarecidos. Objetivo: Avaliar associações independentes entre sarcopenia e seus componentes, índice de massa muscular esquelética apendicular (ASMI) e força de preensão manual (HGS) e fatores relacionados ao hospedeiro, à doença, ao estado nutricional, ao vírus; Avaliar a associação entre os valores do ângulo de fase (AF) e sarcopenia em pacientes infectados pelo HCV. Métodos: Noventa pacientes com hepatite C crônica (média de idade 49,9 + 11,3 anos; 73,3% homens; 67,8% não cirróticos e 32,2% com cirrose compensada) foram submetidos à absorciometria por dupla emissão de raio X para avaliação da massa muscular esquelética apendicular e da massa óssea. Sarcopenia foi definida como a presença de ASMI diminuído e HGS diminuída de acordo com os critérios do European Working Group on Sarcopenia in Older People. Osteopenia e osteoporose foram definidas de acordo com os critérios da Organização Mundial da Saúde. O Questionário Internacional de Atividade Física foi utilizado para determinar o nível de atividade física. As associações foram analisadas por modelos de regressão logística e linear. Resultados: Sarcopenia, ASMI diminuído e HGS diminuída foram encontrados em (5,6%), 12,2% e 17,8% dos pacientes, respectivamente. Na análise multivariada, ASMI diminuído e sarcopenia foram associados positivamente à massa óssea diminuída e inversamente associados ao AF. Considerando o AF como variável dependente, este parâmetro derivado da bioimpedância elétrica (BIA) estava associado independentemente com idade, sexo masculino, diabetes mellitus e sarcopenia. Conclusão: O AF pode ser considerado um bom indicador da sarcopenia e de seus componentes em pacientes com hepatite C crônica. Este parâmetro derivado da BIA tem sido reconhecido como um marcador preciso da qualidade geral da musculatura esquelética.Background: Sarcopenia is a remarkable finding in patients with chronic hepatitis C (CHC). However, the biological mechanisms behind the skeletal muscle loss have not been completely clarified. Objective: To evaluate independent associations between sarcopenia and its components, appendicular skeletal mass index (ASMI) and handgrip strength (HGS) and host-, disease-, nutritional- and virus-related factors and to appraise association between bioelectrical impedance analysis (BIA)-derived phase angle (PhA) values and sarcopenia in patients with chronic hepatitis C. Methods: Ninety outpatients with CHC (mean age, 49.9 + 11.3yrs.; 73.3% males; 67.8% non-cirrhotic and 32.2% with compensated cirrhosis) underwent scanning of ASM and bone mass by dual-energy X-ray absorptiometry. Sarcopenia was defined as the presence of both low ASMI and low HGS according to the European Working Group on Sarcopenia in Older People criteria. Osteopenia and osteoporosis were defined according to the World Health Organization criteria. The International Physical Activity Questionnaire was used to determine the physical activity level. Associations were investigated by logistic and linear regression models. Results: Sarcopenia, low SMI and low HGS were found in (5.6%), 12.2% and 17.8% patients, respectively. In the multivariate analysis, low ASMI and sarcopenia were positively associated with low bone mass and inversely associated with PhA. Low HGS was inversely associated with PhA. Considering the PhA as dependent variable, age, male sex, diabetes mellitus and sarcopenia were independently associated with this BIA-derived measurement. Conclusion PhA may be considered an useful indicator of sarcopenia and its components in patients with CHC. This BIA-derived measurement has been recognized as marker of overall muscle quality.CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorporUniversidade Federal de Minas GeraisPrograma de Pós-Graduação em Ciências Aplicadas à Saúde do AdultoUFMGBrasilMEDICINA - FACULDADE DE MEDICINAhttp://creativecommons.org/licenses/by-nc-nd/3.0/pt/info:eu-repo/semantics/openAccessHepatite C CrônicaSarcopeniaEstado NutricionalVírusForça da MãoHepatite C crônicaSarcopeniaBaixa força de preensão manualBaixo índice de massa esquelética apendicularÂngulo de faseAnormalidades musculares esqueleticasSarcopenia e hepatite c crônica: avaliação dos fatores relacionados ao vírus, ao hospedeiro e ao estilo de vidaSarcopenia and chronic hepatitis C: assessment of factors related to the virus, the host and lifestyleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufmg.br/bitstream/1843/65720/2/license_rdfcfd6801dba008cb6adbd9838b81582abMD52ORIGINALSarcopenia e hepatite c crônica - avaliação dos fatores relacionados ao vírus, ao hospedeiro e ao estilo de vida.pdfSarcopenia e hepatite c crônica - avaliação dos fatores relacionados ao vírus, ao hospedeiro e ao estilo de vida.pdfapplication/pdf2872670https://repositorio.ufmg.br/bitstream/1843/65720/4/Sarcopenia%20e%20hepatite%20c%20cr%c3%b4nica%20-%20avalia%c3%a7%c3%a3o%20dos%20fatores%20relacionados%20ao%20v%c3%adrus%2c%20ao%20hospedeiro%20e%20ao%20estilo%20de%20vida.pdfc8588928edf70be17b9fa2e1d68b2313MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-82118https://repositorio.ufmg.br/bitstream/1843/65720/5/license.txtcda590c95a0b51b4d15f60c9642ca272MD551843/657202024-03-12 10:56:50.57oai:repositorio.ufmg.br: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ório InstitucionalPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-03-12T13:56:50Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
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