Brazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1016/j.phyplu.2021.100154 http://hdl.handle.net/1843/60641 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| id |
UFMG_f56cdf49fd892af4e94584b48be0dea1 |
|---|---|
| oai_identifier_str |
oai:repositorio.ufmg.br:1843/60641 |
| network_acronym_str |
UFMG |
| network_name_str |
Repositório Institucional da UFMG |
| repository_id_str |
|
| spelling |
2023-11-08T13:46:56Z2023-11-08T13:46:56Z20222111https://doi.org/10.1016/j.phyplu.2021.1001542667-0313http://hdl.handle.net/1843/60641CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorBackground: Lychnophora ericoides Mart. (Asteraceae) is a Brazilian plant commonly used in folk medicine to treat pain and inflammation by topical administration. In recent years, this medicine has begun to be used orally. However, no study concerning its toxicity profile has been reported. Objective: The study evaluates the potential toxicity of the ethanolic extract from leaves of the Lychnophora ericoides, through the methods of acute and sub-acute oral administration in mice. Method: An acute toxicity study was performed according to the Organization for Economic Cooperation and Development protocol (OECD 423). A single extract dose of 50, 300, and 2000 mg/kg (n =3/group) was administered orally to female Swiss mice. For subacute toxicity, the protocol OECD 407 was followed. Doses of 50, 300, and 500 mg/kg (n =10/group) of the extract were administered daily to Swiss mice of both sexes for 28 days. Abnormal behavior, muscle strength, toxic symptoms, weight, and death were observed when assessing toxicity. Biochemical analysis, hematological analysis, macroscopic examination, and histopathological examination of several organs were conducted at the end of the treatment period. Results: In acute and subacute toxicity, the extract did not produce mortality. The acute toxicity study revealed alterations in the behavioral test and histopathological changes in the liver, kidney, lung, and spleen. The subacute oral toxicity test showed changes in hematologic and biochemical parameters. Histopathological examination of liver, kidney, spleen, lung, and heart indicated degenerative characteristics with inflammatory infiltrates focus. Conclusion: The study results suggest that oral use of Lychnophora ericoides leaves extract should be performed with caution in low doses in both single and repeated administrations.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASPhytomedicine PlusArnicaToxicidade agudaCerradosBrazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.sciencedirect.com/science/article/pii/S2667031321001366#Barbhara Mota MarinhoAndré Luiz Sena GuimarãesAlfredo Maurício Batista de PaulaSérgio Henrique Sousa SantosVictor Hugo Dantas GuimarãesJaciara Neves SousaDaniel Silva MoraesEmisael Stênio Batista GomesClaudia Regina VieiraSidnei Tavares dos ReisTheles de Oliveira CostaLucyana Conceição Fariasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60641/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALBrazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice.pdfBrazilian Cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice.pdfapplication/pdf19832663https://repositorio.ufmg.br/bitstream/1843/60641/2/Brazilian%20Cerrado%20plant%20%28arnica%29%20Lychnophora%20ericoides%20Mart.%20%28Asteraceae%29%20toxicity%20characterization%20in%20mice.pdfe7deae6dbd94db6225d2c791a63e2631MD521843/606412023-11-08 18:23:59.654oai:repositorio.ufmg.br:1843/60641Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-11-08T21:23:59Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Brazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice |
| title |
Brazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice |
| spellingShingle |
Brazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice Barbhara Mota Marinho Arnica Toxicidade aguda Cerrados |
| title_short |
Brazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice |
| title_full |
Brazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice |
| title_fullStr |
Brazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice |
| title_full_unstemmed |
Brazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice |
| title_sort |
Brazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in mice |
| author |
Barbhara Mota Marinho |
| author_facet |
Barbhara Mota Marinho André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos Victor Hugo Dantas Guimarães Jaciara Neves Sousa Daniel Silva Moraes Emisael Stênio Batista Gomes Claudia Regina Vieira Sidnei Tavares dos Reis Theles de Oliveira Costa Lucyana Conceição Farias |
| author_role |
author |
| author2 |
André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos Victor Hugo Dantas Guimarães Jaciara Neves Sousa Daniel Silva Moraes Emisael Stênio Batista Gomes Claudia Regina Vieira Sidnei Tavares dos Reis Theles de Oliveira Costa Lucyana Conceição Farias |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barbhara Mota Marinho André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos Victor Hugo Dantas Guimarães Jaciara Neves Sousa Daniel Silva Moraes Emisael Stênio Batista Gomes Claudia Regina Vieira Sidnei Tavares dos Reis Theles de Oliveira Costa Lucyana Conceição Farias |
| dc.subject.other.pt_BR.fl_str_mv |
Arnica Toxicidade aguda Cerrados |
| topic |
Arnica Toxicidade aguda Cerrados |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2022 |
| dc.date.issued.fl_str_mv |
2022 |
| dc.date.accessioned.fl_str_mv |
2023-11-08T13:46:56Z |
| dc.date.available.fl_str_mv |
2023-11-08T13:46:56Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/60641 |
| dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.phyplu.2021.100154 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2667-0313 |
| url |
https://doi.org/10.1016/j.phyplu.2021.100154 http://hdl.handle.net/1843/60641 |
| identifier_str_mv |
2667-0313 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Phytomedicine Plus |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
| dc.publisher.initials.fl_str_mv |
UFMG |
| dc.publisher.country.fl_str_mv |
Brasil |
| dc.publisher.department.fl_str_mv |
ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
| instname_str |
Universidade Federal de Minas Gerais (UFMG) |
| instacron_str |
UFMG |
| institution |
UFMG |
| reponame_str |
Repositório Institucional da UFMG |
| collection |
Repositório Institucional da UFMG |
| bitstream.url.fl_str_mv |
https://repositorio.ufmg.br/bitstream/1843/60641/1/License.txt https://repositorio.ufmg.br/bitstream/1843/60641/2/Brazilian%20Cerrado%20plant%20%28arnica%29%20Lychnophora%20ericoides%20Mart.%20%28Asteraceae%29%20toxicity%20characterization%20in%20mice.pdf |
| bitstream.checksum.fl_str_mv |
fa505098d172de0bc8864fc1287ffe22 e7deae6dbd94db6225d2c791a63e2631 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
| repository.mail.fl_str_mv |
|
| _version_ |
1803589555248431104 |