Mixed tumors of the canine mammary glands: evaluation of prognostic factors, treatment, and overall survival
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/39982 |
Resumo: | Mixed tumors are the most frequent mammary gland neoplasms in bitches; however, studies that thoroughly describe their clinicopathological data, treatment approaches, and the survival of bitches with mixed tumors are scarce. This study evaluated the epidemiological and clinicopathological data, prognostic factors, and therapeutic approaches for bitches with mixed tumors. In all, 162 benign mixed tumors, 682 carcinomas in mixed tumors, and 60 carcinosarcomas were included. Regarding tumor size, T3 lesions were predominantly associated with carcinosarcomas, while T1 and T2 lesions occurred more frequently in benign mixed tumors and in carcinomas in mixed tumors. Based on clinical staging, most bitches with benign mixed tumors presented with stage I tumors; 92% of bitches with carcinomas in mixed tumors presented with stage I–III tumors, while 8% presented with stage IV–V tumors; and 70% of bitches with carcinosarcomas presented with stage I–III tumors, while 30% presented with stage IV–V tumors. Surgery was curative for bitches with benign mixed tumors and for those with stage I–III carcinomas in mixed tumors. Combination therapy in bitches with carcinomas in mixed tumors (IV–V) and carcinosarcomas resulted in a higher overall survival compared with bitches who underwent surgery only. Carcinosarcomas presented higher relapse rates and distant metastases than carcinomas in mixed tumors did. |
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2022-03-11T15:17:15Z2022-03-11T15:17:15Z201822710.1016/j.vas.2018.09.0032451943Xhttp://hdl.handle.net/1843/39982Mixed tumors are the most frequent mammary gland neoplasms in bitches; however, studies that thoroughly describe their clinicopathological data, treatment approaches, and the survival of bitches with mixed tumors are scarce. This study evaluated the epidemiological and clinicopathological data, prognostic factors, and therapeutic approaches for bitches with mixed tumors. In all, 162 benign mixed tumors, 682 carcinomas in mixed tumors, and 60 carcinosarcomas were included. Regarding tumor size, T3 lesions were predominantly associated with carcinosarcomas, while T1 and T2 lesions occurred more frequently in benign mixed tumors and in carcinomas in mixed tumors. Based on clinical staging, most bitches with benign mixed tumors presented with stage I tumors; 92% of bitches with carcinomas in mixed tumors presented with stage I–III tumors, while 8% presented with stage IV–V tumors; and 70% of bitches with carcinosarcomas presented with stage I–III tumors, while 30% presented with stage IV–V tumors. Surgery was curative for bitches with benign mixed tumors and for those with stage I–III carcinomas in mixed tumors. Combination therapy in bitches with carcinomas in mixed tumors (IV–V) and carcinosarcomas resulted in a higher overall survival compared with bitches who underwent surgery only. Carcinosarcomas presented higher relapse rates and distant metastases than carcinomas in mixed tumors did.Os tumores mistos são as neoplasias de glândula mamária mais frequentes em cadelas; no entanto, estudos que minuciosamente descrevem seus dados clínico-patológicos, abordagens de tratamento e a sobrevivência de cadelas com tumores mistos são escasso. Este estudo avaliou os dados epidemiológicos e clínico-patológicos, fatores prognósticos e condutas terapêuticas para cadelas com tumores mistos. Ao todo, 162 tumores mistos benignos, 682 carcinomas em tumores e 60 carcinossarcomas foram incluídos. Em relação ao tamanho do tumor, as lesões T3 foram predominantemente associadas com carcinossarcomas, enquanto lesões T1 e T2 ocorreram mais frequentemente em tumores mistos benignos e em carcinomas em tumores mistos. Com base no estadiamento clínico, a maioria das cadelas com tumores mistos benignos apresentou estágio I tumores; 92% das cadelas com carcinomas em tumores mistos apresentaram tumores em estágio I-III, enquanto 8% apresentaram com tumores em estágio IV–V; e 70% das cadelas com carcinossarcoma apresentaram tumores em estágio I-III, enquanto 30% apresentavam tumores em estágio IV–V. A cirurgia foi curativa para cadelas com tumores mistos benignos e para aquelas com Carcinomas estágio I-III em tumores mistos. Terapia combinada em cadelas com carcinomas em tumores mistos (IV-V) e carcinossarcomas resultaram em maior sobrevida global em comparação com cadelas submetidas apenas à cirurgia. Os carcinossarcomas apresentaram maiores taxas de recidiva e metástases à distância do que os carcinomas em tumores mistos.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE PATOLOGIAVeterinary and animal scienceCarcinossarcomaCarcinoma em tumor mistoQuimioterapiaNeoplasiasMixed tumors of the canine mammary glands: evaluation of prognostic factors, treatment, and overall survivalTumores mistos das glândulas mamárias caninas: avaliação de fatores prognósticos, tratamento e sobrevida globalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386670/Fernanda Camargo NunesKarine Araújo DamascenoCecília Bonolo de CamposAngélica Cavalheiro BertagnolliGleidice Eunice LavalleGeovanni Dantas Cassaliapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/39982/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINAL2019_Mixed tumors of the canine mammary glands- Evaluation of prognostic.pdf2019_Mixed tumors of the canine mammary glands- Evaluation of prognostic.pdfapplication/pdf561205https://repositorio.ufmg.br/bitstream/1843/39982/2/2019_Mixed%20tumors%20of%20the%20canine%20mammary%20glands-%20Evaluation%20of%20prognostic.pdf287f88191b2a776c34b57283b2b42412MD521843/399822022-03-11 12:17:15.194oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-03-11T15:17:15Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Mixed tumors of the canine mammary glands: evaluation of prognostic factors, treatment, and overall survival |
dc.title.alternative.pt_BR.fl_str_mv |
Tumores mistos das glândulas mamárias caninas: avaliação de fatores prognósticos, tratamento e sobrevida global |
title |
Mixed tumors of the canine mammary glands: evaluation of prognostic factors, treatment, and overall survival |
spellingShingle |
Mixed tumors of the canine mammary glands: evaluation of prognostic factors, treatment, and overall survival Fernanda Camargo Nunes Carcinossarcoma Carcinoma em tumor misto Quimioterapia Neoplasias |
title_short |
Mixed tumors of the canine mammary glands: evaluation of prognostic factors, treatment, and overall survival |
title_full |
Mixed tumors of the canine mammary glands: evaluation of prognostic factors, treatment, and overall survival |
title_fullStr |
Mixed tumors of the canine mammary glands: evaluation of prognostic factors, treatment, and overall survival |
title_full_unstemmed |
Mixed tumors of the canine mammary glands: evaluation of prognostic factors, treatment, and overall survival |
title_sort |
Mixed tumors of the canine mammary glands: evaluation of prognostic factors, treatment, and overall survival |
author |
Fernanda Camargo Nunes |
author_facet |
Fernanda Camargo Nunes Karine Araújo Damasceno Cecília Bonolo de Campos Angélica Cavalheiro Bertagnolli Gleidice Eunice Lavalle Geovanni Dantas Cassali |
author_role |
author |
author2 |
Karine Araújo Damasceno Cecília Bonolo de Campos Angélica Cavalheiro Bertagnolli Gleidice Eunice Lavalle Geovanni Dantas Cassali |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Fernanda Camargo Nunes Karine Araújo Damasceno Cecília Bonolo de Campos Angélica Cavalheiro Bertagnolli Gleidice Eunice Lavalle Geovanni Dantas Cassali |
dc.subject.other.pt_BR.fl_str_mv |
Carcinossarcoma Carcinoma em tumor misto Quimioterapia Neoplasias |
topic |
Carcinossarcoma Carcinoma em tumor misto Quimioterapia Neoplasias |
description |
Mixed tumors are the most frequent mammary gland neoplasms in bitches; however, studies that thoroughly describe their clinicopathological data, treatment approaches, and the survival of bitches with mixed tumors are scarce. This study evaluated the epidemiological and clinicopathological data, prognostic factors, and therapeutic approaches for bitches with mixed tumors. In all, 162 benign mixed tumors, 682 carcinomas in mixed tumors, and 60 carcinosarcomas were included. Regarding tumor size, T3 lesions were predominantly associated with carcinosarcomas, while T1 and T2 lesions occurred more frequently in benign mixed tumors and in carcinomas in mixed tumors. Based on clinical staging, most bitches with benign mixed tumors presented with stage I tumors; 92% of bitches with carcinomas in mixed tumors presented with stage I–III tumors, while 8% presented with stage IV–V tumors; and 70% of bitches with carcinosarcomas presented with stage I–III tumors, while 30% presented with stage IV–V tumors. Surgery was curative for bitches with benign mixed tumors and for those with stage I–III carcinomas in mixed tumors. Combination therapy in bitches with carcinomas in mixed tumors (IV–V) and carcinosarcomas resulted in a higher overall survival compared with bitches who underwent surgery only. Carcinosarcomas presented higher relapse rates and distant metastases than carcinomas in mixed tumors did. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2022-03-11T15:17:15Z |
dc.date.available.fl_str_mv |
2022-03-11T15:17:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/39982 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/j.vas.2018.09.003 |
dc.identifier.issn.pt_BR.fl_str_mv |
2451943X |
identifier_str_mv |
10.1016/j.vas.2018.09.003 2451943X |
url |
http://hdl.handle.net/1843/39982 |
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eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Veterinary and animal science |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
ICB - DEPARTAMENTO DE PATOLOGIA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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