Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/60890 |
Resumo: | Purpose: To evaluate and compare the effects of homologous and heterologous PRP (Platelet-Rich Plasma) on the quality and speed of skin wound healing, compared to Poor Platelet Plasma (PPP).Methods: Twenty-one male adult rabbits were used; two for preparing homologous PRP, with the rest of them separated randomly in three groups, according to the treatment received: PPP – control (n=5), homologous PRP (n=7), heterologous (n=7). Excisional skin wounds were made on the back of the animals, for the application of homologous and heterologous PPP and PRP. At the 14th post-operative day (POD), the animals were subjected to a new wound, and the treatments were inverted. The wounds were evaluated macroscopically and histologically.Results: A larger percentage of scar retraction was observed on the group treated with heterologous PRP, compared to homologous PRP, at the third POD, an increase of 25.03% (p=0.01). No other statistically significant differences among treatments were observed. Among every group, skin healing was efficient, without local adverse effects.Conclusions: Heterologous PRP contributed with more tissue retraction at the beginning of the wound healing process. After this, there were no differences on the wound healing skin process treated with PRP or PPP. However, our findings suggest the presence of others plasmatic factors, besides platelets,which could also contribute to the wound healing process, and thus, should be further investigated. |
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2023-11-13T19:45:41Z2023-11-13T19:45:41Z2020351011110.1590/s0102-86502020010000000616782674http://hdl.handle.net/1843/60890Purpose: To evaluate and compare the effects of homologous and heterologous PRP (Platelet-Rich Plasma) on the quality and speed of skin wound healing, compared to Poor Platelet Plasma (PPP).Methods: Twenty-one male adult rabbits were used; two for preparing homologous PRP, with the rest of them separated randomly in three groups, according to the treatment received: PPP – control (n=5), homologous PRP (n=7), heterologous (n=7). Excisional skin wounds were made on the back of the animals, for the application of homologous and heterologous PPP and PRP. At the 14th post-operative day (POD), the animals were subjected to a new wound, and the treatments were inverted. The wounds were evaluated macroscopically and histologically.Results: A larger percentage of scar retraction was observed on the group treated with heterologous PRP, compared to homologous PRP, at the third POD, an increase of 25.03% (p=0.01). No other statistically significant differences among treatments were observed. Among every group, skin healing was efficient, without local adverse effects.Conclusions: Heterologous PRP contributed with more tissue retraction at the beginning of the wound healing process. After this, there were no differences on the wound healing skin process treated with PRP or PPP. However, our findings suggest the presence of others plasmatic factors, besides platelets,which could also contribute to the wound healing process, and thus, should be further investigated.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE CIRURGIAMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARActa Cirúrgica BrasileiraPlatelet-Rich PlasmaRabbitsWound HealingPlatelet-Rich PlasmaWound HealingRabbitsEffects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbitsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.1590/s0102-865020200100000006Raquel de OliveirameiraDaniel Nogueira Mendes BragaLeni Safira Gonçalves PinheiroIzabela Ferreira Gontijo AmorimLeonardo de Souza VasconcellosLuiz Ronaldo Albertiapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60890/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALEffects of homologous and heterologous rich pdfa.pdfEffects of homologous and heterologous rich pdfa.pdfapplication/pdf554343https://repositorio.ufmg.br/bitstream/1843/60890/2/Effects%20of%20homologous%20and%20heterologous%20rich%20pdfa.pdf0c3bdbfba2a061f9eb18008427dc9d6fMD521843/608902023-11-13 18:33:47.412oai:repositorio.ufmg.br:1843/60890Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-11-13T21:33:47Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits |
title |
Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits |
spellingShingle |
Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits Raquel de Oliveirameira Platelet-Rich Plasma Wound Healing Rabbits Platelet-Rich Plasma Rabbits Wound Healing |
title_short |
Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits |
title_full |
Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits |
title_fullStr |
Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits |
title_full_unstemmed |
Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits |
title_sort |
Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits |
author |
Raquel de Oliveirameira |
author_facet |
Raquel de Oliveirameira Daniel Nogueira Mendes Braga Leni Safira Gonçalves Pinheiro Izabela Ferreira Gontijo Amorim Leonardo de Souza Vasconcellos Luiz Ronaldo Alberti |
author_role |
author |
author2 |
Daniel Nogueira Mendes Braga Leni Safira Gonçalves Pinheiro Izabela Ferreira Gontijo Amorim Leonardo de Souza Vasconcellos Luiz Ronaldo Alberti |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Raquel de Oliveirameira Daniel Nogueira Mendes Braga Leni Safira Gonçalves Pinheiro Izabela Ferreira Gontijo Amorim Leonardo de Souza Vasconcellos Luiz Ronaldo Alberti |
dc.subject.por.fl_str_mv |
Platelet-Rich Plasma Wound Healing Rabbits |
topic |
Platelet-Rich Plasma Wound Healing Rabbits Platelet-Rich Plasma Rabbits Wound Healing |
dc.subject.other.pt_BR.fl_str_mv |
Platelet-Rich Plasma Rabbits Wound Healing |
description |
Purpose: To evaluate and compare the effects of homologous and heterologous PRP (Platelet-Rich Plasma) on the quality and speed of skin wound healing, compared to Poor Platelet Plasma (PPP).Methods: Twenty-one male adult rabbits were used; two for preparing homologous PRP, with the rest of them separated randomly in three groups, according to the treatment received: PPP – control (n=5), homologous PRP (n=7), heterologous (n=7). Excisional skin wounds were made on the back of the animals, for the application of homologous and heterologous PPP and PRP. At the 14th post-operative day (POD), the animals were subjected to a new wound, and the treatments were inverted. The wounds were evaluated macroscopically and histologically.Results: A larger percentage of scar retraction was observed on the group treated with heterologous PRP, compared to homologous PRP, at the third POD, an increase of 25.03% (p=0.01). No other statistically significant differences among treatments were observed. Among every group, skin healing was efficient, without local adverse effects.Conclusions: Heterologous PRP contributed with more tissue retraction at the beginning of the wound healing process. After this, there were no differences on the wound healing skin process treated with PRP or PPP. However, our findings suggest the presence of others plasmatic factors, besides platelets,which could also contribute to the wound healing process, and thus, should be further investigated. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2023-11-13T19:45:41Z |
dc.date.available.fl_str_mv |
2023-11-13T19:45:41Z |
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info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/60890 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1590/s0102-865020200100000006 |
dc.identifier.issn.pt_BR.fl_str_mv |
16782674 |
identifier_str_mv |
10.1590/s0102-865020200100000006 16782674 |
url |
http://hdl.handle.net/1843/60890 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.none.fl_str_mv |
Acta Cirúrgica Brasileira |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE CIRURGIA MED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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