Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines

• Autor(a) principal: Micheletti, Ana Camila
• Data de Publicação: 2011
• Outros Autores: Honda, Neli Kika, Lima, Dênis Pires de, Beatriz, Adilson, Sant'ana, Maria Rita, Carvalho, Nádia Cristina Pereira, Matos, Maria de Fatima Cepa, Queiróz, Lyara Meira Marinho, Bogo, Danielle, Zorzatto, José Roberto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMS
• Texto Completo: https://repositorio.ufms.br/handle/123456789/752; http://dx.doi.org/10.1590/S0100-40422011000600019
• topic: Xantonas; Staphylococcus Aureus; Linhagem Celular Tumoral; Xanthones; Cell Line, Tumor

A series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized derivatives revealed selective activity against Staphylococcus aureus (Gram-positive), and the most promising results are for a multidrug resistant strain, for which six of these compounds showed good activity (MICs 4 µg/mL). Many derivatives inhibited tumor cells growth and most compounds were active on multiple lines.