Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil

Detalhes bibliográficos
Autor(a) principal: Chang, Marilene Rodrigues
Data de Publicação: 2008
Outros Autores: Correia, Flávia Patussi, Costa, Leonora Correa, Xavier, Paula Cristhina Niz, Palhares, Durval Batista, Taira, Deborah Ledesma, Paniago, Anamaria Mello Miranda, Pontes, Elenir Rose Jardim Cury, Machado, Vanessa Escobar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMS
Texto Completo: https://repositorio.ufms.br/handle/123456789/132
Resumo: The incidence of Candida bloodstream infection has increased over the past years. In the Center-West region of Brazil, data on candidemia are scarce. This paper reports a retrospective analysis of 96 cases of Candida bloodstream infection at a Brazilian tertiary-care teaching hospital in the state of Mato Grosso do Sul, from January 1998 to December 2006. Demographic, clinical and laboratory data were collected from medical records and from the hospital's laboratory database. Patients' ages ranged from three days to 92 years, with 53 (55.2%) adults and 43 (44.8%) children. Of the latter, 25 (58.1%) were newborns. The risk conditions most often found were: long period of hospitalization, utilization of venous central catheter, and previous use of antibiotics. Fifty-eight (60.4%) patients died during the hospitalization period and eight (13.7%) of them died 30 days after the diagnosis of candidemia. Candida albicans (45.8%) was the most prevalent species, followed by C. parapsilosis (34.4%), C. tropicalis (14.6%) and C. glabrata (5.2%). This is the first report of Candida bloodstream infection in the state of Mato Grosso do Sul and it highlights the importance of considering the possibility of invasive Candida infection in patients exposed to risk factors, particularly among neonates and the elderly.
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spelling 2011-07-12T19:53:46Z2021-09-30T19:56:50Z2008CHANG, Marilene Rodrigues et al . Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil. Rev. Inst. Med. trop. S. Paulo, São Paulo, v. 50, n. 5, Oct. 2008 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652008000500003&lng=en&nrm=iso>. access on 12 July 2011. doi: 10.1590/S0036-46652008000500003.https://repositorio.ufms.br/handle/123456789/13210.1590/S0036-46652008000500003The incidence of Candida bloodstream infection has increased over the past years. In the Center-West region of Brazil, data on candidemia are scarce. This paper reports a retrospective analysis of 96 cases of Candida bloodstream infection at a Brazilian tertiary-care teaching hospital in the state of Mato Grosso do Sul, from January 1998 to December 2006. Demographic, clinical and laboratory data were collected from medical records and from the hospital's laboratory database. Patients' ages ranged from three days to 92 years, with 53 (55.2%) adults and 43 (44.8%) children. Of the latter, 25 (58.1%) were newborns. The risk conditions most often found were: long period of hospitalization, utilization of venous central catheter, and previous use of antibiotics. Fifty-eight (60.4%) patients died during the hospitalization period and eight (13.7%) of them died 30 days after the diagnosis of candidemia. Candida albicans (45.8%) was the most prevalent species, followed by C. parapsilosis (34.4%), C. tropicalis (14.6%) and C. glabrata (5.2%). This is the first report of Candida bloodstream infection in the state of Mato Grosso do Sul and it highlights the importance of considering the possibility of invasive Candida infection in patients exposed to risk factors, particularly among neonates and the elderly.A incidência de infecções na corrente sangüínea causada por Candida spp. tem aumentado nos últimos anos. Na região Centro-Oeste do Brasil, os dados sobre candidemia são escassos. Realizamos uma análise retrospectiva de casos de infecção na corrente sangüínea por Candida em um hospital terciário de ensino de Mato Grosso do Sul. Noventa e seis episódios diagnosticados de janeiro de 1998 a dezembro de 2006 foram incluídos no estudo. Os dados demográficos e clínicos foram obtidos de prontuários; os dados laboratoriais provieram de registros do laboratório hospitalar. Dos pacientes, 43 (44,8%) eram crianças e 53 (55,2%) adultos, com idades variando de três dias a 92 anos. Das crianças, 25 (58,1%) eram recém-nascidas. As condições de risco mais encontradas foram: prolongado tempo de internação, uso de cateter venoso central e uso prévio de antibióticos. Cinqüenta e oito (60,4%) pacientes foram a óbito durante a hospitalização e oito (13,7%) deles foram a óbito 30 dias após o diagnóstico de candidemia. Candida albicans (45,8%) foi a espécie mais prevalente seguida por C. parapsilosis (34,4%), C. tropicalis (14,6%) e C. glabrata (5,2%). Esta é a primeira descrição de infecção na corrente sangüínea por espécies de Candida em Mato Grosso do Sul, confirmando a importância da suspeita clínica de infecções invasivas por tais microrganismos na evolução de pacientes expostos a fatores de risco, principalmente no caso de idosos e neonatos.engRevista do Instituto de Medicina Tropical de São PauloCandidemiaFatores de RiscoBloodstream infectionCandida sppCandida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, BrazilInfecção na corrente sangüínea por Candida spp. dados de um hospital universitário em Mato Grosso do Sul, Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleChang, Marilene RodriguesCorreia, Flávia PatussiCosta, Leonora CorreaXavier, Paula Cristhina NizPalhares, Durval BatistaTaira, Deborah LedesmaPaniago, Anamaria Mello MirandaPontes, Elenir Rose Jardim CuryMachado, Vanessa Escobarinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMSinstname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSTHUMBNAILCandida bloodstream infection.pdf.jpgCandida bloodstream infection.pdf.jpgGenerated Thumbnailimage/jpeg1625https://repositorio.ufms.br/bitstream/123456789/132/4/Candida%20bloodstream%20infection.pdf.jpge13d5ce03e7d3bce43cd53dd76fb4743MD54ORIGINALCandida bloodstream infection.pdfCandida bloodstream infection.pdfapplication/pdf127361https://repositorio.ufms.br/bitstream/123456789/132/1/Candida%20bloodstream%20infection.pdfe96691017893294cbcbea945d95dd768MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufms.br/bitstream/123456789/132/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTCandida bloodstream infection.pdf.txtCandida bloodstream infection.pdf.txtExtracted texttext/plain20210https://repositorio.ufms.br/bitstream/123456789/132/3/Candida%20bloodstream%20infection.pdf.txtfb8bb9faec727b3d49e0432c03533f6bMD53123456789/1322021-09-30 15:56:50.139oai:repositorio.ufms.br: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Repositório InstitucionalPUBhttps://repositorio.ufms.br/oai/requestri.prograd@ufms.bropendoar:21242021-09-30T19:56:50Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS)false
dc.title.pt_BR.fl_str_mv Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil
dc.title.alternative.pt_BR.fl_str_mv Infecção na corrente sangüínea por Candida spp. dados de um hospital universitário em Mato Grosso do Sul, Brasil
title Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil
spellingShingle Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil
Chang, Marilene Rodrigues
Candidemia
Fatores de Risco
Bloodstream infection
Candida spp
title_short Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil
title_full Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil
title_fullStr Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil
title_full_unstemmed Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil
title_sort Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil
author Chang, Marilene Rodrigues
author_facet Chang, Marilene Rodrigues
Correia, Flávia Patussi
Costa, Leonora Correa
Xavier, Paula Cristhina Niz
Palhares, Durval Batista
Taira, Deborah Ledesma
Paniago, Anamaria Mello Miranda
Pontes, Elenir Rose Jardim Cury
Machado, Vanessa Escobar
author_role author
author2 Correia, Flávia Patussi
Costa, Leonora Correa
Xavier, Paula Cristhina Niz
Palhares, Durval Batista
Taira, Deborah Ledesma
Paniago, Anamaria Mello Miranda
Pontes, Elenir Rose Jardim Cury
Machado, Vanessa Escobar
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chang, Marilene Rodrigues
Correia, Flávia Patussi
Costa, Leonora Correa
Xavier, Paula Cristhina Niz
Palhares, Durval Batista
Taira, Deborah Ledesma
Paniago, Anamaria Mello Miranda
Pontes, Elenir Rose Jardim Cury
Machado, Vanessa Escobar
dc.subject.por.fl_str_mv Candidemia
Fatores de Risco
Bloodstream infection
Candida spp
topic Candidemia
Fatores de Risco
Bloodstream infection
Candida spp
description The incidence of Candida bloodstream infection has increased over the past years. In the Center-West region of Brazil, data on candidemia are scarce. This paper reports a retrospective analysis of 96 cases of Candida bloodstream infection at a Brazilian tertiary-care teaching hospital in the state of Mato Grosso do Sul, from January 1998 to December 2006. Demographic, clinical and laboratory data were collected from medical records and from the hospital's laboratory database. Patients' ages ranged from three days to 92 years, with 53 (55.2%) adults and 43 (44.8%) children. Of the latter, 25 (58.1%) were newborns. The risk conditions most often found were: long period of hospitalization, utilization of venous central catheter, and previous use of antibiotics. Fifty-eight (60.4%) patients died during the hospitalization period and eight (13.7%) of them died 30 days after the diagnosis of candidemia. Candida albicans (45.8%) was the most prevalent species, followed by C. parapsilosis (34.4%), C. tropicalis (14.6%) and C. glabrata (5.2%). This is the first report of Candida bloodstream infection in the state of Mato Grosso do Sul and it highlights the importance of considering the possibility of invasive Candida infection in patients exposed to risk factors, particularly among neonates and the elderly.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2011-07-12T19:53:46Z
dc.date.available.fl_str_mv 2021-09-30T19:56:50Z
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dc.identifier.citation.fl_str_mv CHANG, Marilene Rodrigues et al . Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil. Rev. Inst. Med. trop. S. Paulo, São Paulo, v. 50, n. 5, Oct. 2008 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652008000500003&lng=en&nrm=iso>. access on 12 July 2011. doi: 10.1590/S0036-46652008000500003.
dc.identifier.uri.fl_str_mv https://repositorio.ufms.br/handle/123456789/132
dc.identifier.doi.none.fl_str_mv 10.1590/S0036-46652008000500003
identifier_str_mv CHANG, Marilene Rodrigues et al . Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil. Rev. Inst. Med. trop. S. Paulo, São Paulo, v. 50, n. 5, Oct. 2008 . Available from <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652008000500003&lng=en&nrm=iso>. access on 12 July 2011. doi: 10.1590/S0036-46652008000500003.
10.1590/S0036-46652008000500003
url https://repositorio.ufms.br/handle/123456789/132
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dc.publisher.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo
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