Antibacterial activity of orsellinates
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMS |
Texto Completo: | https://repositorio.ufms.br/handle/123456789/1255 http://dx.doi.org/10.1590/S1517-83822003000300002 |
Resumo: | Para obter novos compostos com atividade antibacteriana, foram preparados os derivados 2,4-diidróxi-6-metilbenzoatos (orselinatos) e o ácido 2,4-diidróxi-6-metilbenzóico (ácido orselínico) através de reações de alcoólise do ácido lecanórico. Todas as substâncias foram testadas contra bactérias Gram-positivas e Gram-negativas pelo método da microdiluição. Staphylococcus aureus, Xanthomonas campestris var. vesicatoria and Ralstonia solanacearum foram mais sensíveis ao 2,4-diidróxi-6-metilbenzoato de n-propila, 2,4-diidróxi-6-metilbenzoato de n-pentila e 2,4-diidróxi-6-metilbenzoato de n-hexila com valores de CIM (Concentração Inibitória Mínima) variando de 62,5 a 7,8 µg.mL1. Esses resultados mostraram que a homologação da cadeia carbônica pode conduzir a compostos mais ativos. |
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2012-04-17T18:25:09Z2021-09-30T19:56:27Z2003GOMES, Alcir Teixeira et al . Antibacterial activity of orsellinates. Braz. J. Microbiol., São Paulo, v. 34, n. 3, jul. 2003 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000300002&lng=pt&nrm=iso>. acessos em 28 nov. 2011. http://dx.doi.org/10.1590/S1517-83822003000300002.https://repositorio.ufms.br/handle/123456789/1255http://dx.doi.org/10.1590/S1517-83822003000300002Para obter novos compostos com atividade antibacteriana, foram preparados os derivados 2,4-diidróxi-6-metilbenzoatos (orselinatos) e o ácido 2,4-diidróxi-6-metilbenzóico (ácido orselínico) através de reações de alcoólise do ácido lecanórico. Todas as substâncias foram testadas contra bactérias Gram-positivas e Gram-negativas pelo método da microdiluição. Staphylococcus aureus, Xanthomonas campestris var. vesicatoria and Ralstonia solanacearum foram mais sensíveis ao 2,4-diidróxi-6-metilbenzoato de n-propila, 2,4-diidróxi-6-metilbenzoato de n-pentila e 2,4-diidróxi-6-metilbenzoato de n-hexila com valores de CIM (Concentração Inibitória Mínima) variando de 62,5 a 7,8 µg.mL1. Esses resultados mostraram que a homologação da cadeia carbônica pode conduzir a compostos mais ativos.ABSTRACT - In order to obtain new compounds with antibacterial activity, the derivatives 2,4-dihydroxy-6-methylbenzoic acid (orsellinic acid) and 2,4-dihydroxy-6-methylbenzoates (orsellinates) were obtained through alcoholyses of lecanoric acid. All these substances were tested against Gram-positive and Gram-negative bacteria by a microdilution method. Staphylococcus aureus, Xanthomonas campestris var. vesicatoria and Ralstonia solanacearum were most sensitive to n-propyl 2,4-dihydroxy-6-methylbenzoate, n-pentyl 2,4-dihydroxy-6-methylbenzoate and n-hexyl 2,4-dihydroxy-6-methylbenzoate with MIC (Minimal Inhibitory Concentration) values ranging from 62.5 to 7.8 µg×mL1. These results showed that homologation in carbon chain may lead to compounds with more pronunced activities.engBrazilian Journal of MicrobiologyÁcidosBactériasBactérias Gram-PositivasBactérias Gram-NegativasMicrobiologiaAcidsBacteriaGram-Negative BacteriaBacterial SheddingGram-Positive BacteriaMicrobiologyAntibacterial activity of orsellinatesAtividade antibacterina de orselinatosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGomes, Alcir TeixeiraSmania Júnior, ArturSeidel, CintiaSmania, Elza de Fátima AlbinoHonda, Neli KikaRoese, Fernanda MesquitaMuzzi, Rozanna Marquesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMSinstname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSTHUMBNAILAntibacterial activity of orsellinates.pdf.jpgAntibacterial activity of orsellinates.pdf.jpgGenerated Thumbnailimage/jpeg1657https://repositorio.ufms.br/bitstream/123456789/1255/4/Antibacterial%20activity%20of%20orsellinates.pdf.jpg1749f371a923a93b247038725d3182caMD54TEXTAntibacterial activity of orsellinates.pdf.txtAntibacterial activity of orsellinates.pdf.txtExtracted texttext/plain12288https://repositorio.ufms.br/bitstream/123456789/1255/3/Antibacterial%20activity%20of%20orsellinates.pdf.txt893f6d303f33a956792f82ac622e9a05MD53ORIGINALAntibacterial activity of orsellinates.pdfAntibacterial activity of orsellinates.pdfapplication/pdf171756https://repositorio.ufms.br/bitstream/123456789/1255/1/Antibacterial%20activity%20of%20orsellinates.pdfc37302e200ad3c1d177a413c0216362eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufms.br/bitstream/123456789/1255/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/12552021-09-30 15:56:27.144oai:repositorio.ufms.br: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Repositório InstitucionalPUBhttps://repositorio.ufms.br/oai/requestri.prograd@ufms.bropendoar:21242021-09-30T19:56:27Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS)false |
dc.title.pt_BR.fl_str_mv |
Antibacterial activity of orsellinates |
dc.title.alternative.pt_BR.fl_str_mv |
Atividade antibacterina de orselinatos |
title |
Antibacterial activity of orsellinates |
spellingShingle |
Antibacterial activity of orsellinates Gomes, Alcir Teixeira Ácidos Bactérias Bactérias Gram-Positivas Bactérias Gram-Negativas Microbiologia Acids Bacteria Gram-Negative Bacteria Bacterial Shedding Gram-Positive Bacteria Microbiology |
title_short |
Antibacterial activity of orsellinates |
title_full |
Antibacterial activity of orsellinates |
title_fullStr |
Antibacterial activity of orsellinates |
title_full_unstemmed |
Antibacterial activity of orsellinates |
title_sort |
Antibacterial activity of orsellinates |
author |
Gomes, Alcir Teixeira |
author_facet |
Gomes, Alcir Teixeira Smania Júnior, Artur Seidel, Cintia Smania, Elza de Fátima Albino Honda, Neli Kika Roese, Fernanda Mesquita Muzzi, Rozanna Marques |
author_role |
author |
author2 |
Smania Júnior, Artur Seidel, Cintia Smania, Elza de Fátima Albino Honda, Neli Kika Roese, Fernanda Mesquita Muzzi, Rozanna Marques |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Alcir Teixeira Smania Júnior, Artur Seidel, Cintia Smania, Elza de Fátima Albino Honda, Neli Kika Roese, Fernanda Mesquita Muzzi, Rozanna Marques |
dc.subject.por.fl_str_mv |
Ácidos Bactérias Bactérias Gram-Positivas Bactérias Gram-Negativas Microbiologia Acids Bacteria Gram-Negative Bacteria Bacterial Shedding Gram-Positive Bacteria Microbiology |
topic |
Ácidos Bactérias Bactérias Gram-Positivas Bactérias Gram-Negativas Microbiologia Acids Bacteria Gram-Negative Bacteria Bacterial Shedding Gram-Positive Bacteria Microbiology |
description |
Para obter novos compostos com atividade antibacteriana, foram preparados os derivados 2,4-diidróxi-6-metilbenzoatos (orselinatos) e o ácido 2,4-diidróxi-6-metilbenzóico (ácido orselínico) através de reações de alcoólise do ácido lecanórico. Todas as substâncias foram testadas contra bactérias Gram-positivas e Gram-negativas pelo método da microdiluição. Staphylococcus aureus, Xanthomonas campestris var. vesicatoria and Ralstonia solanacearum foram mais sensíveis ao 2,4-diidróxi-6-metilbenzoato de n-propila, 2,4-diidróxi-6-metilbenzoato de n-pentila e 2,4-diidróxi-6-metilbenzoato de n-hexila com valores de CIM (Concentração Inibitória Mínima) variando de 62,5 a 7,8 µg.mL1. Esses resultados mostraram que a homologação da cadeia carbônica pode conduzir a compostos mais ativos. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003 |
dc.date.accessioned.fl_str_mv |
2012-04-17T18:25:09Z |
dc.date.available.fl_str_mv |
2021-09-30T19:56:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GOMES, Alcir Teixeira et al . Antibacterial activity of orsellinates. Braz. J. Microbiol., São Paulo, v. 34, n. 3, jul. 2003 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000300002&lng=pt&nrm=iso>. acessos em 28 nov. 2011. http://dx.doi.org/10.1590/S1517-83822003000300002. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufms.br/handle/123456789/1255 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/S1517-83822003000300002 |
identifier_str_mv |
GOMES, Alcir Teixeira et al . Antibacterial activity of orsellinates. Braz. J. Microbiol., São Paulo, v. 34, n. 3, jul. 2003 . Disponível em <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822003000300002&lng=pt&nrm=iso>. acessos em 28 nov. 2011. http://dx.doi.org/10.1590/S1517-83822003000300002. |
url |
https://repositorio.ufms.br/handle/123456789/1255 http://dx.doi.org/10.1590/S1517-83822003000300002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Brazilian Journal of Microbiology |
publisher.none.fl_str_mv |
Brazilian Journal of Microbiology |
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reponame:Repositório Institucional da UFMS instname:Universidade Federal de Mato Grosso do Sul (UFMS) instacron:UFMS |
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Universidade Federal de Mato Grosso do Sul (UFMS) |
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UFMS |
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Repositório Institucional da UFMS |
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Repositório Institucional da UFMS |
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