Synthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMS |
Texto Completo: | https://repositorio.ufms.br/handle/123456789/5322 |
Resumo: | Quinazolinone is a versatile lead molecule for designing potential bioactive agents. The compounds that have quinazolin-4-ones moiety are associated with interesting biological activities such as antifungal, antibacterial, antiviral, antitubercular and anticancer. In view of this we have undertaken synthesis of various thiadiazol substituted quinazolin-4-(3H)-ones. Novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones (5a-5h) were synthesized by reaction of 5-alkyl/aryl substituted 1, 3, 4-thiadiazoles with 2-methyl/phenyl-4H-1, 3-benzooxazin-4-ones in the presence of pyridine. All the synthesized compounds were characterized by spectral and physical data. In vitro anticancer activity of all the synthesized compounds was determined by MTT assay on HeLa (Human cervical cancer cell) cells. Most active compounds found in vitro studies were further evaluated for their in vivo activity on Liquid tumor (Ehrlich’s Ascites Carcinoma; EAC) induced mice. The anticancer activity of compound 5f was found to be comparable to that of cisplatin against HeLa cells and was also effective in preventing the growth of tumor in mice as indicated by decrease in progressive gain in body weight as well as increase in life span when compared to animals of control group. |
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2022-10-27T13:01:44Z2022-10-27T13:01:44Z2010-12-271984-6428https://repositorio.ufms.br/handle/123456789/5322Quinazolinone is a versatile lead molecule for designing potential bioactive agents. The compounds that have quinazolin-4-ones moiety are associated with interesting biological activities such as antifungal, antibacterial, antiviral, antitubercular and anticancer. In view of this we have undertaken synthesis of various thiadiazol substituted quinazolin-4-(3H)-ones. Novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones (5a-5h) were synthesized by reaction of 5-alkyl/aryl substituted 1, 3, 4-thiadiazoles with 2-methyl/phenyl-4H-1, 3-benzooxazin-4-ones in the presence of pyridine. All the synthesized compounds were characterized by spectral and physical data. In vitro anticancer activity of all the synthesized compounds was determined by MTT assay on HeLa (Human cervical cancer cell) cells. Most active compounds found in vitro studies were further evaluated for their in vivo activity on Liquid tumor (Ehrlich’s Ascites Carcinoma; EAC) induced mice. The anticancer activity of compound 5f was found to be comparable to that of cisplatin against HeLa cells and was also effective in preventing the growth of tumor in mice as indicated by decrease in progressive gain in body weight as well as increase in life span when compared to animals of control group.engFundação Universidade Federal de Mato Grosso do SulUFMSBrasilOrbital: The Electronic Journal of ChemistryAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessCNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICAAsciteCarcinomaNeoplasiasQuinazolinonasColorimetriaTécnicas de Química AnalíticaHeLaLinhagem CelularAntineoplásicosAscitesNeoplasmsQuinazolinonesColorimetryChemistry Techniques, AnalyticalCell LineAntineoplastic AgentsSynthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-onesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJoseph, AlexPai, AravindaSrinivasan, K. K.Kedar, TukaramThomas, Angel TreasaE. M., JessySingla, Rajeev K.reponame:Repositório Institucional da UFMSinstname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSLICENSElicense.txtlicense.txttext/plain; charset=utf-82031https://repositorio.ufms.br/bitstream/123456789/5322/3/license.txt9671aa5ac42cb06edaf75013367dfe04MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufms.br/bitstream/123456789/5322/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52ORIGINALSynthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones.pdfSynthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones.pdfapplication/pdf279262https://repositorio.ufms.br/bitstream/123456789/5322/1/Synthesis%20and%20anticancer%20activity%20of%20some%20novel%203-%281%2c%203%2c%204-thiadiazol-2-yl%29-quinazolin-4-%283H%29-ones.pdf9e1d0dc75281861b64fe9f4b0922ea94MD51123456789/53222022-10-27 09:18:16.38oai:repositorio.ufms.br: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ório InstitucionalPUBhttps://repositorio.ufms.br/oai/requestri.prograd@ufms.bropendoar:21242022-10-27T13:18:16Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS)false |
dc.title.pt_BR.fl_str_mv |
Synthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones |
title |
Synthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones |
spellingShingle |
Synthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones Joseph, Alex CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA Ascite Carcinoma Neoplasias Quinazolinonas Colorimetria Técnicas de Química Analítica HeLa Linhagem Celular Antineoplásicos Ascites Neoplasms Quinazolinones Colorimetry Chemistry Techniques, Analytical Cell Line Antineoplastic Agents |
title_short |
Synthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones |
title_full |
Synthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones |
title_fullStr |
Synthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones |
title_full_unstemmed |
Synthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones |
title_sort |
Synthesis and anticancer activity of some novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones |
author |
Joseph, Alex |
author_facet |
Joseph, Alex Pai, Aravinda Srinivasan, K. K. Kedar, Tukaram Thomas, Angel Treasa E. M., Jessy Singla, Rajeev K. |
author_role |
author |
author2 |
Pai, Aravinda Srinivasan, K. K. Kedar, Tukaram Thomas, Angel Treasa E. M., Jessy Singla, Rajeev K. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Joseph, Alex Pai, Aravinda Srinivasan, K. K. Kedar, Tukaram Thomas, Angel Treasa E. M., Jessy Singla, Rajeev K. |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
topic |
CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA Ascite Carcinoma Neoplasias Quinazolinonas Colorimetria Técnicas de Química Analítica HeLa Linhagem Celular Antineoplásicos Ascites Neoplasms Quinazolinones Colorimetry Chemistry Techniques, Analytical Cell Line Antineoplastic Agents |
dc.subject.por.fl_str_mv |
Ascite Carcinoma Neoplasias Quinazolinonas Colorimetria Técnicas de Química Analítica HeLa Linhagem Celular Antineoplásicos Ascites Neoplasms Quinazolinones Colorimetry Chemistry Techniques, Analytical Cell Line Antineoplastic Agents |
description |
Quinazolinone is a versatile lead molecule for designing potential bioactive agents. The compounds that have quinazolin-4-ones moiety are associated with interesting biological activities such as antifungal, antibacterial, antiviral, antitubercular and anticancer. In view of this we have undertaken synthesis of various thiadiazol substituted quinazolin-4-(3H)-ones. Novel 3-(1, 3, 4-thiadiazol-2-yl)-quinazolin-4-(3H)-ones (5a-5h) were synthesized by reaction of 5-alkyl/aryl substituted 1, 3, 4-thiadiazoles with 2-methyl/phenyl-4H-1, 3-benzooxazin-4-ones in the presence of pyridine. All the synthesized compounds were characterized by spectral and physical data. In vitro anticancer activity of all the synthesized compounds was determined by MTT assay on HeLa (Human cervical cancer cell) cells. Most active compounds found in vitro studies were further evaluated for their in vivo activity on Liquid tumor (Ehrlich’s Ascites Carcinoma; EAC) induced mice. The anticancer activity of compound 5f was found to be comparable to that of cisplatin against HeLa cells and was also effective in preventing the growth of tumor in mice as indicated by decrease in progressive gain in body weight as well as increase in life span when compared to animals of control group. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-12-27 |
dc.date.accessioned.fl_str_mv |
2022-10-27T13:01:44Z |
dc.date.available.fl_str_mv |
2022-10-27T13:01:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufms.br/handle/123456789/5322 |
dc.identifier.issn.pt_BR.fl_str_mv |
1984-6428 |
identifier_str_mv |
1984-6428 |
url |
https://repositorio.ufms.br/handle/123456789/5322 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Orbital: The Electronic Journal of Chemistry |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Fundação Universidade Federal de Mato Grosso do Sul |
dc.publisher.initials.fl_str_mv |
UFMS |
dc.publisher.country.fl_str_mv |
Brasil |
publisher.none.fl_str_mv |
Fundação Universidade Federal de Mato Grosso do Sul |
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reponame:Repositório Institucional da UFMS instname:Universidade Federal de Mato Grosso do Sul (UFMS) instacron:UFMS |
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Universidade Federal de Mato Grosso do Sul (UFMS) |
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UFMS |
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UFMS |
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Repositório Institucional da UFMS |
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Repositório Institucional da UFMS |
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