AVALIAÇÃO DA TITULAÇÃO DE ANTICORPOS FRENTE A DIFERENTES PROTOCOLOS DE PRIMOVACINAÇÃO ANTIRRABICA EM UMA POPULAÇAO DE CÃES DE CAMPO GRANDE, MATO GROSSO DO SUL

Detalhes bibliográficos
Autor(a) principal: Jeannette Leon Thames
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFMS
Texto Completo: https://repositorio.ufms.br/handle/123456789/5922
Resumo: Protection of humans against urban rabies is mainly achieved by prophylactic measures applied to dogs and cats, which include vaccines that induce minimal antibody titers (≥0.5 IU/ml). mass, many animals do not achieve protective antibody titers after vaccination. Few studies have examined factors associated with the failure of dogs to achieve an adequate antibody titer after vaccination. The objective of this work was to evaluate the antibody titration against different protocols of anti-rabies primary vaccination in dogs. The study consisted of 32 dogs over 4 months of age divided into three experimental groups. The animals had their blood collected prior to the first vaccination, for the titration of anti-rabies antibodies. In Group 1, a blood sample and first anti-rabies vaccine were collected, followed by a new sample collection on days 30 and 180. In Group 2, a sample collection and first anti-rabies vaccine, a new sample collection and vaccine booster were performed anti-rabies on day 30, and only sample collection on days 60 and 180. In Group 3, sample collection and first anti-rabies vaccine were performed, sample collection and vaccine booster on day 7, sample collection and vaccine booster on day 30, and only sample collection on days 60 and 180. 120 serum samples were collected and sent to the Pasteur Institute in São Paulo where they were processed using the Fluorescent Focus Inhibition Reaction Test (RIFFT), in order to quantitatively determine the titre of anti-rabies antibodies. Descriptive statistics were performed and the results were analyzed using the Kruskal Wallis, Wilcoxon-Mann-Whitney test, which shows that protocol 2 concentrates and maintains the highest amount of antibodies in dogs first vaccinated on day 180... Miniature and small dogs obtained the highest amount of antibodies than medium-sized dogs. These data demonstrate that there is variation in the obtaining of anti-rabies antibodies in the face of the first vaccination in the population of dogs studied. Keyword: immunization, rabies, vaccines, canines, zoonosis
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spelling 2023-05-22T12:58:14Z2023-05-22T12:58:14Z2023https://repositorio.ufms.br/handle/123456789/5922Protection of humans against urban rabies is mainly achieved by prophylactic measures applied to dogs and cats, which include vaccines that induce minimal antibody titers (≥0.5 IU/ml). mass, many animals do not achieve protective antibody titers after vaccination. Few studies have examined factors associated with the failure of dogs to achieve an adequate antibody titer after vaccination. The objective of this work was to evaluate the antibody titration against different protocols of anti-rabies primary vaccination in dogs. The study consisted of 32 dogs over 4 months of age divided into three experimental groups. The animals had their blood collected prior to the first vaccination, for the titration of anti-rabies antibodies. In Group 1, a blood sample and first anti-rabies vaccine were collected, followed by a new sample collection on days 30 and 180. In Group 2, a sample collection and first anti-rabies vaccine, a new sample collection and vaccine booster were performed anti-rabies on day 30, and only sample collection on days 60 and 180. In Group 3, sample collection and first anti-rabies vaccine were performed, sample collection and vaccine booster on day 7, sample collection and vaccine booster on day 30, and only sample collection on days 60 and 180. 120 serum samples were collected and sent to the Pasteur Institute in São Paulo where they were processed using the Fluorescent Focus Inhibition Reaction Test (RIFFT), in order to quantitatively determine the titre of anti-rabies antibodies. Descriptive statistics were performed and the results were analyzed using the Kruskal Wallis, Wilcoxon-Mann-Whitney test, which shows that protocol 2 concentrates and maintains the highest amount of antibodies in dogs first vaccinated on day 180... Miniature and small dogs obtained the highest amount of antibodies than medium-sized dogs. These data demonstrate that there is variation in the obtaining of anti-rabies antibodies in the face of the first vaccination in the population of dogs studied. Keyword: immunization, rabies, vaccines, canines, zoonosisRESUMO A proteção dos seres humanos contra a raiva urbana é alcançada principalmente por medidas profiláticas aplicadas a cães e gatos, que incluem vacinas que induzem o mínimo de títulos de anticorpos (≥0,5 UI/ml).. Contudo, nas campanhas de vacinação em massa, numerosos animais não alcançam títulos protetores de anticorpos após a vacinação. Poucos estudos examinaram os fatores associados a falha de cães atingirem um título adequado de anticorpos após a vacinação. O objetivo deste trabalho foi avaliar a titulação de anticorpos frente a diferentes protocolos da primovacinação antirrábica em cães. O estudo foi composto por 32 caes acima de 4 meses de idade divididos em três grupos experimentais. Os animais, tiveram seu sangue coletado previamente a primo vacinação, para a titulação de anticorpos antirrábicos. No Grupo 1, se realizou a coleta de amostra sanguínea e primeira vacina antirrábica, seguida de nova coleta de amostra nos dias 30 e 180. No Grupo 2, foi realizada coleta de amostra e primeira vacina antirrábica, nova coleta de amostra e reforço de vacina antirrábica no dia 30, e somente coleta de amostra nos dias 60 e 180. No Grupo 3, foi realizada a coleta de amostra e primeira vacina antirrábica, coleta de amostra e reforço vacinal no dia 7, coleta de amostra e reforço de vacina no dia 30, e somente coleta de amostra nos dias 60 e 180. Foram coletadas 120 amostras de soro encaminhadas ao Instituto Pasteur de São Paulo onde foram processadas mediante a Prova de Reação de Inibição de Focos Fluorescentes (RIFFT), a fim de determinar quantitativamente a titulação de anticorpos antirrábicos. Se realizou estatística descritiva e os resultados foram analisados pelo teste de Kruskal Wallis, Wilcoxon-Mann-Whitney, mostram o protocolo 2 quem concentra e mantem a maior quantidade de anticorpos em cães primovacinados no dia 180... Os cães miniatura e pequenos obtiveram maior quantidade de anticorpos que os cães de porte médio. Esses dados demonstram que há variação da obtenção de anticorpos antirrábicos frente à primo vacinação na população de cães estudados. Palavra-chave: imunização, raiva, vacinas, caninos, zoonoseFundação Universidade Federal de Mato Grosso do SulUFMSBrasilIMUNIZAÇÃORAIVAVACINASCANINOSZOONOSEAVALIAÇÃO DA TITULAÇÃO DE ANTICORPOS FRENTE A DIFERENTES PROTOCOLOS DE PRIMOVACINAÇÃO ANTIRRABICA EM UMA POPULAÇAO DE CÃES DE CAMPO GRANDE, MATO GROSSO DO SULinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisVeronica Jorge Babo TerraJeannette Leon Thamesinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UFMSinstname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSORIGINALTrabalho Final.pdfTrabalho Final.pdfapplication/pdf6622066https://repositorio.ufms.br/bitstream/123456789/5922/-1/Trabalho%20Final.pdf4b7cd5a9dba1613dfbec5fb7db30a094MD5-1123456789/59222023-05-22 08:58:17.057oai:repositorio.ufms.br:123456789/5922Repositório InstitucionalPUBhttps://repositorio.ufms.br/oai/requestri.prograd@ufms.bropendoar:21242023-05-22T12:58:17Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS)false
dc.title.pt_BR.fl_str_mv AVALIAÇÃO DA TITULAÇÃO DE ANTICORPOS FRENTE A DIFERENTES PROTOCOLOS DE PRIMOVACINAÇÃO ANTIRRABICA EM UMA POPULAÇAO DE CÃES DE CAMPO GRANDE, MATO GROSSO DO SUL
title AVALIAÇÃO DA TITULAÇÃO DE ANTICORPOS FRENTE A DIFERENTES PROTOCOLOS DE PRIMOVACINAÇÃO ANTIRRABICA EM UMA POPULAÇAO DE CÃES DE CAMPO GRANDE, MATO GROSSO DO SUL
spellingShingle AVALIAÇÃO DA TITULAÇÃO DE ANTICORPOS FRENTE A DIFERENTES PROTOCOLOS DE PRIMOVACINAÇÃO ANTIRRABICA EM UMA POPULAÇAO DE CÃES DE CAMPO GRANDE, MATO GROSSO DO SUL
Jeannette Leon Thames
IMUNIZAÇÃO
RAIVA
VACINAS
CANINOS
ZOONOSE
title_short AVALIAÇÃO DA TITULAÇÃO DE ANTICORPOS FRENTE A DIFERENTES PROTOCOLOS DE PRIMOVACINAÇÃO ANTIRRABICA EM UMA POPULAÇAO DE CÃES DE CAMPO GRANDE, MATO GROSSO DO SUL
title_full AVALIAÇÃO DA TITULAÇÃO DE ANTICORPOS FRENTE A DIFERENTES PROTOCOLOS DE PRIMOVACINAÇÃO ANTIRRABICA EM UMA POPULAÇAO DE CÃES DE CAMPO GRANDE, MATO GROSSO DO SUL
title_fullStr AVALIAÇÃO DA TITULAÇÃO DE ANTICORPOS FRENTE A DIFERENTES PROTOCOLOS DE PRIMOVACINAÇÃO ANTIRRABICA EM UMA POPULAÇAO DE CÃES DE CAMPO GRANDE, MATO GROSSO DO SUL
title_full_unstemmed AVALIAÇÃO DA TITULAÇÃO DE ANTICORPOS FRENTE A DIFERENTES PROTOCOLOS DE PRIMOVACINAÇÃO ANTIRRABICA EM UMA POPULAÇAO DE CÃES DE CAMPO GRANDE, MATO GROSSO DO SUL
title_sort AVALIAÇÃO DA TITULAÇÃO DE ANTICORPOS FRENTE A DIFERENTES PROTOCOLOS DE PRIMOVACINAÇÃO ANTIRRABICA EM UMA POPULAÇAO DE CÃES DE CAMPO GRANDE, MATO GROSSO DO SUL
author Jeannette Leon Thames
author_facet Jeannette Leon Thames
author_role author
dc.contributor.advisor1.fl_str_mv Veronica Jorge Babo Terra
dc.contributor.author.fl_str_mv Jeannette Leon Thames
contributor_str_mv Veronica Jorge Babo Terra
dc.subject.por.fl_str_mv IMUNIZAÇÃO
RAIVA
VACINAS
CANINOS
ZOONOSE
topic IMUNIZAÇÃO
RAIVA
VACINAS
CANINOS
ZOONOSE
description Protection of humans against urban rabies is mainly achieved by prophylactic measures applied to dogs and cats, which include vaccines that induce minimal antibody titers (≥0.5 IU/ml). mass, many animals do not achieve protective antibody titers after vaccination. Few studies have examined factors associated with the failure of dogs to achieve an adequate antibody titer after vaccination. The objective of this work was to evaluate the antibody titration against different protocols of anti-rabies primary vaccination in dogs. The study consisted of 32 dogs over 4 months of age divided into three experimental groups. The animals had their blood collected prior to the first vaccination, for the titration of anti-rabies antibodies. In Group 1, a blood sample and first anti-rabies vaccine were collected, followed by a new sample collection on days 30 and 180. In Group 2, a sample collection and first anti-rabies vaccine, a new sample collection and vaccine booster were performed anti-rabies on day 30, and only sample collection on days 60 and 180. In Group 3, sample collection and first anti-rabies vaccine were performed, sample collection and vaccine booster on day 7, sample collection and vaccine booster on day 30, and only sample collection on days 60 and 180. 120 serum samples were collected and sent to the Pasteur Institute in São Paulo where they were processed using the Fluorescent Focus Inhibition Reaction Test (RIFFT), in order to quantitatively determine the titre of anti-rabies antibodies. Descriptive statistics were performed and the results were analyzed using the Kruskal Wallis, Wilcoxon-Mann-Whitney test, which shows that protocol 2 concentrates and maintains the highest amount of antibodies in dogs first vaccinated on day 180... Miniature and small dogs obtained the highest amount of antibodies than medium-sized dogs. These data demonstrate that there is variation in the obtaining of anti-rabies antibodies in the face of the first vaccination in the population of dogs studied. Keyword: immunization, rabies, vaccines, canines, zoonosis
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-22T12:58:14Z
dc.date.available.fl_str_mv 2023-05-22T12:58:14Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
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dc.identifier.uri.fl_str_mv https://repositorio.ufms.br/handle/123456789/5922
url https://repositorio.ufms.br/handle/123456789/5922
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Universidade Federal de Mato Grosso do Sul
dc.publisher.initials.fl_str_mv UFMS
dc.publisher.country.fl_str_mv Brasil
publisher.none.fl_str_mv Fundação Universidade Federal de Mato Grosso do Sul
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMS
instname:Universidade Federal de Mato Grosso do Sul (UFMS)
instacron:UFMS
instname_str Universidade Federal de Mato Grosso do Sul (UFMS)
instacron_str UFMS
institution UFMS
reponame_str Repositório Institucional da UFMS
collection Repositório Institucional da UFMS
bitstream.url.fl_str_mv https://repositorio.ufms.br/bitstream/123456789/5922/-1/Trabalho%20Final.pdf
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repository.name.fl_str_mv Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS)
repository.mail.fl_str_mv ri.prograd@ufms.br
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